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NameEndothelin-1 receptor
Synonyms
  • Endothelin A receptor
  • ET-A
  • ETA
  • ETA-R
  • ETRA
  • hET-AR
Gene NameEDNRA
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001040|Endothelin-1 receptor
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
Number of residues427
Molecular Weight48721.76
Theoretical pI8.41
GO Classification
Functions
  • phosphatidylinositol phospholipase C activity
  • endothelin receptor activity
Processes
  • head development
  • positive regulation of cytosolic calcium ion concentration
  • neural crest cell development
  • respiratory gaseous exchange
  • activation of adenylate cyclase activity
  • vasoconstriction
  • heart development
  • response to hypoxia
  • G-protein coupled receptor signaling pathway
  • smooth muscle contraction
  • activation of phospholipase C activity
  • patterning of blood vessels
  • regulation of blood pressure
  • signal transduction
  • negative regulation of cAMP biosynthetic process
  • artery smooth muscle contraction
  • endothelin receptor signaling pathway
  • cell proliferation
  • enteric nervous system development
  • in utero embryonic development
  • glucose transport
Components
  • integral component of plasma membrane
  • plasma membrane
  • cytosol
General FunctionPhosphatidylinositol phospholipase c activity
Specific FunctionReceptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.
Pfam Domain Function
Transmembrane Regions81-102 113-132 160-181 206-229 257-278 307-328 348-372
GenBank Protein ID238636
UniProtKB IDP25101
UniProtKB Entry NameEDNRA_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0010366|Endothelin-1 receptor (EDNRA)
ATGGAAACCCTTTGCCTCAGGGCATCCTTTTGGCTGGCACTGGTTGGATGTGTAATCAGT
GATAATCCTGAGAGATACAGCACAAATCTAAGCAATCATGTGGATGATTTCACCACTTTT
CGTGGCACAGAGCTCAGCTTCCTGGTTACCACTCATCAACCCACTAATTTGGTCCTACCC
AGCAATGGCTCAATGCACAACTATTGCCCACAGCAGACTAAAATTACTTCAGCTTTCAAA
TACATTAACACTGTGATATCTTGTACTATTTTCATCGTGGGAATGGTGGGGAATGCAACT
CTGCTCAGGATCATTTACCAGAACAAATGTATGAGGAATGGCCCCAACGCGCTGATAGCC
AGTCTTGCCCTTGGAGACCTTATCTATGTGGTCATTGATCTCCCTATCAATGTATTTAAG
TTCTACCAAGATGTAAAGGACTGGTGGCTCTTCGGGTTCTATTTCTGTATGCCCTTGGTG
TGCACTGCGATCTTCTACACCCTCATGACTTGTGAGATGTTGAACAGAAGGAATGGCAGC
TTGAGAATTGCCCTCAGTGAACATCTTAAGCAGCGTCGAGAAGTGGCAAAAACAGTTTTC
TGCTTGGTTGTAATTTTTGCTCTTTGCTGGTTCCCTCTTCATTTAAGCCGTATATTGAAG
AAAACTGTGTATAACGAGATGGACAAGAACCGATGTGAATTACTTAGTTTCTTACTGCTC
ATGGATTACATCGGTATTAACTTGGCAACCATGAATTCATGTATAAACCCCATAGCTCTG
TATTTTGTGAGCAAGAAATTTAAAAATTGTTTCCAGTCATGCCTCTGCTGCTGCTGTTAC
CAGTCCAAAAGTCTGATGACCTCGGTCCCCATGAACGGAACAAGCATCCAGTGGAAGAAC
CACGATCAAAACAACCACAACACAGACCGGAGCAGCCATAAGGACAGCATGAACTGA
GenBank Gene IDS63938
GeneCard IDNot Available
GenAtlas IDEDNRA
HGNC IDHGNC:3179
Chromosome Location4
Locus4q31.23
References
  1. Adachi M, Yang YY, Furuichi Y, Miyamoto C: Cloning and characterization of cDNA encoding human A-type endothelin receptor. Biochem Biophys Res Commun. 1991 Nov 14;180(3):1265-72. 1719979
  2. Cyr C, Huebner K, Druck T, Kris R: Cloning and chromosomal localization of a human endothelin ETA receptor. Biochem Biophys Res Commun. 1991 Nov 27;181(1):184-90. 1659806
  3. Hosoda K, Nakao K, Hiroshi-Arai, Suga S, Ogawa Y, Mukoyama M, Shirakami G, Saito Y, Nakanishi S, Imura H: Cloning and expression of human endothelin-1 receptor cDNA. FEBS Lett. 1991 Aug 5;287(1-2):23-6. 1652463
  4. Arai H, Nakao K, Hosoda K, Ogawa Y, Nakagawa O, Komatsu Y, Imura H: [Molecular cloning of human endothelin receptors and their expression in vascular endothelial cells and smooth muscle cells]. Jpn Circ J. 1992;56 Suppl 5:1303-7. 1291713
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