NameNeuropeptide Y receptor type 1
Synonyms
  • NPY1-R
  • NPYR
  • NPYY1
Gene NameNPY1R
OrganismHuman
Amino acid sequence
>lcl|BSEQ0011754|Neuropeptide Y receptor type 1
MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLA
LIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQ
CVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMT
DEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKR
RNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNL
LFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVS
KTSLKQASPVAFKKINNNDDNEKI
Number of residues384
Molecular Weight44391.535
Theoretical pI7.86
GO Classification
Functions
  • neuropeptide Y receptor activity
  • pancreatic polypeptide receptor activity
  • peptide YY receptor activity
Processes
  • locomotory behavior
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
  • sensory perception of pain
  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
  • regulation of multicellular organism growth
  • positive regulation of vasoconstriction
  • regulation of blood pressure
  • neuropeptide signaling pathway
  • negative regulation of hormone secretion
  • negative regulation of cytosolic calcium ion concentration
  • feeding behavior
  • glucose metabolic process
  • outflow tract morphogenesis
  • response to estradiol
  • peristalsis
  • blood circulation
  • cell surface receptor signaling pathway
Components
  • plasma membrane
  • synaptic vesicle
  • axon
  • cytosol
  • integral component of plasma membrane
General FunctionPeptide yy receptor activity
Specific FunctionReceptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.
Pfam Domain Function
Transmembrane Regions45-65 77-97 117-137 155-175 212-232 261-281 300-320
GenBank Protein IDNot Available
UniProtKB IDP25929
UniProtKB Entry NameNPY1R_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0011755|Neuropeptide Y receptor type 1 (NPY1R)
ATGAATTCAACATTATTTTCCCAGGTTGAAAATCATTCAGTCCACTCTAATTTCTCAGAG
AAGAATGCCCAGCTTCTGGCTTTTGAAAATGATGATTGTCATCTGCCCTTGGCCATGATA
TTTACCTTAGCTCTTGCTTATGGAGCTGTGATCATTCTTGGTGTCTCTGGAAACCTGGCC
TTGATCATAATCATCTTGAAACAAAAGGAGATGAGAAATGTTACCAACATCCTGATTGTG
AACCTTTCCTTCTCAGACTTGCTTGTTGCCATCATGTGTCTCCCCTTTACATTTGTCTAC
ACATTAATGGACCACTGGGTCTTTGGTGAGGCGATGTGTAAGTTGAATCCTTTTGTGCAA
TGTGTTTCAATCACTGTGTCCATTTTCTCTCTGGTTCTCATTGCTGTGGAACGACATCAG
CTGATAATCAACCCTCGAGGGTGGAGACCAAATAATAGACATGCTTATGTAGGTATTGCT
GTGATTTGGGTCCTTGCTGTGGCTTCTTCTTTGCCTTTCCTGATCTACCAAGTAATGACT
GATGAGCCGTTCCAAAATGTAACACTTGATGCGTACAAAGACAAATACGTGTGCTTTGAT
CAATTTCCATCGGACTCTCATAGGTTGTCTTATACCACTCTCCTCTTGGTGCTGCAGTAT
TTTGGTCCACTTTGTTTTATATTTATTTGCTACTTCAAGATATATATACGCCTAAAAAGG
AGAAACAACATGATGGACAAGATGAGAGACAATAAGTACAGGTCCAGTGAAACCAAAAGA
ATCAATATCATGCTGCTCTCCATTGTGGTAGCATTTGCAGTCTGCTGGCTCCCTCTTACC
ATCTTTAACACTGTGTTTGATTGGAATCATCAGATCATTGCTACCTGCAACCACAATCTG
TTATTCCTGCTCTGCCACCTCACAGCAATGATATCCACTTGTGTCAACCCCATATTTTAT
GGGTTCCTGAACAAAAACTTCCAGAGAGACTTGCAGTTCTTCTTCAACTTTTGTGATTTC
CGGTCTCGGGATGATGATTATGAAACAATAGCCATGTCCACGATGCACACAGATGTTTCC
AAAACTTCTTTGAAGCAAGCAAGCCCAGTCGCATTTAAAAAAATCAACAACAATGATGAT
AATGAAAAAATCTGA
GenBank Gene IDM88461
GeneCard IDNot Available
GenAtlas IDNPY1R
HGNC IDHGNC:7956
Chromosome Location4
Locus4q31.3-q32
References
  1. Larhammar D, Blomqvist AG, Yee F, Jazin E, Yoo H, Wahlested C: Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type. J Biol Chem. 1992 Jun 5;267(16):10935-8. 1317848
  2. Herzog H, Hort YJ, Ball HJ, Hayes G, Shine J, Selbie LA: Cloned human neuropeptide Y receptor couples to two different second messenger systems. Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):5794-8. 1321422
  3. Herzog H, Baumgartner M, Vivero C, Selbie LA, Auer B, Shine J: Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor. J Biol Chem. 1993 Mar 25;268(9):6703-7. 8095935
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