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NameTumor necrosis factor receptor superfamily member 5
Synonyms
  • B-cell surface antigen CD40
  • Bp50
  • CD40L receptor
  • CDw40
  • TNFRSF5
Gene NameCD40
OrganismHuman
Amino acid sequence
>lcl|BSEQ0002379|Tumor necrosis factor receptor superfamily member 5
MVRLPLQCVLWGCLLTAVHPEPPTACREKQYLINSQCCSLCQPGQKLVSDCTEFTETECL
PCGESEFLDTWNRETHCHQHKYCDPNLGLRVQQKGTSETDTICTCEEGWHCTSEACESCV
LHRSCSPGFGVKQIATGVSDTICEPCPVGFFSNVSSAFEKCHPWTSCETKDLVVQQAGTN
KTDVVCGPQDRLRALVVIPIIFGILFAILLVLVFIKKVAKKPTNKAPHPKQEPQEINFPD
DLPGSNTAAPVQETLHGCQPVTQEDGKESRISVQERQ
Number of residues277
Molecular Weight30618.76
Theoretical pI5.57
GO Classification
Functions
  • antigen binding
  • enzyme binding
  • tumor necrosis factor-activated receptor activity
  • ubiquitin protein ligase binding
  • signal transducer activity
  • receptor activity
Processes
  • positive regulation of GTPase activity
  • positive regulation of tyrosine phosphorylation of Stat1 protein
  • protein kinase B signaling
  • platelet activation
  • cellular response to lipopolysaccharide
  • protein complex assembly
  • positive regulation of endothelial cell apoptotic process
  • cellular calcium ion homeostasis
  • positive regulation of protein phosphorylation
  • regulation of immunoglobulin secretion
  • positive regulation of MAP kinase activity
  • regulation of cell proliferation
  • immune response-regulating cell surface receptor signaling pathway
  • apoptotic signaling pathway
  • positive regulation of protein kinase C signaling
  • tumor necrosis factor-mediated signaling pathway
  • cellular response to mechanical stimulus
  • positive regulation of interleukin-12 production
  • regulation of immune response
  • positive regulation of I-kappaB kinase/NF-kappaB signaling
  • positive regulation of NF-kappaB transcription factor activity
  • positive regulation of transcription from RNA polymerase II promoter
  • positive regulation of B cell proliferation
  • multicellular organismal development
  • defense response to virus
  • B cell proliferation
  • defense response to protozoan
  • response to lipopolysaccharide
  • inflammatory response
  • positive regulation of isotype switching to IgG isotypes
Components
  • cell surface
  • CD40 receptor complex
  • extracellular exosome
  • external side of plasma membrane
  • integral component of plasma membrane
  • cytoplasm
  • intracellular membrane-bounded organelle
  • plasma membrane
  • extracellular space
General FunctionUbiquitin protein ligase binding
Specific FunctionReceptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.
Pfam Domain Function
Transmembrane Regions194-215
GenBank Protein ID29851
UniProtKB IDP25942
UniProtKB Entry NameTNR5_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0016348|Tumor necrosis factor receptor superfamily member 5 (CD40)
ATGGTTCGTCTGCCTCTGCAGTGCGTCCTCTGGGGCTGCTTGCTGACCGCTGTCCATCCA
GAACCACCCACTGCATGCAGAGAAAAACAGTACCTAATAAACAGTCAGTGCTGTTCTTTG
TGCCAGCCAGGACAGAAACTGGTGAGTGACTGCACAGAGTTCACTGAAACGGAATGCCTT
CCTTGCGGTGAAAGCGAATTCCTAGACACCTGGAACAGAGAGACACACTGCCACCAGCAC
AAATACTGCGACCCCAACCTAGGGCTTCGGGTCCAGCAGAAGGGCACCTCAGAAACAGAC
ACCATCTGCACCTGTGAAGAAGGCTGGCACTGTACGAGTGAGGCCTGTGAGAGCTGTGTC
CTGCACCGCTCATGCTCGCCCGGCTTTGGGGTCAAGCAGATTGCTACAGGGGTTTCTGAT
ACCATCTGCGAGCCCTGCCCAGTCGGCTTCTTCTCCAATGTGTCATCTGCTTTCGAAAAA
TGTCACCCTTGGACAAGCTGTGAGACCAAAGACCTGGTTGTGCAACAGGCAGGCACAAAC
AAGACTGATGTTGTCTGTGGTCCCCAGGATCGGCTGAGAGCCCTGGTGGTGATCCCCATC
ATCTTCGGGATCCTGTTTGCCATCCTCTTGGTGCTGGTCTTTATCAAAAAGGTGGCCAAG
AAGCCAACCAATAAGGCCCCCCACCCCAAGCAGGAACCCCAGGAGATCAATTTTCCCGAC
GATCTTCCTGGCTCCAACACTGCTGCTCCAGTGCAGGAGACTTTACATGGATGCCAACCG
GTCACCCAGGAGGATGGCAAAGAGAGTCGCATCTCAGTGCAGGAGAGACAGTGA
GenBank Gene IDX60592
GeneCard IDNot Available
GenAtlas IDCD40
HGNC IDHGNC:11919
Chromosome Location20
Locus20q12-q13.2
References
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  5. Braesch-Andersen S, Paulie S, Koho H, Nika H, Aspenstrom P, Perlmann P: Biochemical characteristics and partial amino acid sequence of the receptor-like human B cell and carcinoma antigen CDw40. J Immunol. 1989 Jan 15;142(2):562-7. 2463309
  6. Zhang Z, Henzel WJ: Signal peptide prediction based on analysis of experimentally verified cleavage sites. Protein Sci. 2004 Oct;13(10):2819-24. Epub 2004 Aug 31. 15340161
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  8. Sato T, Irie S, Reed JC: A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40. FEBS Lett. 1995 Jan 23;358(2):113-8. 7530216
  9. Cheng G, Cleary AM, Ye ZS, Hong DI, Lederman S, Baltimore D: Involvement of CRAF1, a relative of TRAF, in CD40 signaling. Science. 1995 Mar 10;267(5203):1494-8. 7533327
  10. Pullen SS, Miller HG, Everdeen DS, Dang TT, Crute JJ, Kehry MR: CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization. Biochemistry. 1998 Aug 25;37(34):11836-45. 9718306
  11. Mizushima S, Fujita M, Ishida T, Azuma S, Kato K, Hirai M, Otsuka M, Yamamoto T, Inoue J: Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5). Gene. 1998 Jan 30;207(2):135-40. 9511754
  12. Kashiwada M, Shirakata Y, Inoue JI, Nakano H, Okazaki K, Okumura K, Yamamoto T, Nagaoka H, Takemori T: Tumor necrosis factor receptor-associated factor 6 (TRAF6) stimulates extracellular signal-regulated kinase (ERK) activity in CD40 signaling along a ras-independent pathway. J Exp Med. 1998 Jan 19;187(2):237-44. 9432981
  13. Bajorath J, Aruffo A: Construction and analysis of a detailed three-dimensional model of the ligand binding domain of the human B cell receptor CD40. Proteins. 1997 Jan;27(1):59-70. 9037712
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  15. Ni CZ, Welsh K, Leo E, Chiou CK, Wu H, Reed JC, Ely KR: Molecular basis for CD40 signaling mediated by TRAF3. Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10395-9. 10984535
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