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NameTumor necrosis factor receptor superfamily member 5
  • B-cell surface antigen CD40
  • Bp50
  • CD40L receptor
  • CDw40
Gene NameCD40
Amino acid sequence
>lcl|BSEQ0002379|Tumor necrosis factor receptor superfamily member 5
Number of residues277
Molecular Weight30618.76
Theoretical pI5.57
GO Classification
  • signal transducer activity
  • receptor activity
  • enzyme binding
  • antigen binding
  • ubiquitin protein ligase binding
  • tumor necrosis factor-activated receptor activity
  • positive regulation of interleukin-12 production
  • cellular response to mechanical stimulus
  • positive regulation of I-kappaB kinase/NF-kappaB signaling
  • regulation of immune response
  • positive regulation of NF-kappaB transcription factor activity
  • positive regulation of B cell proliferation
  • positive regulation of transcription from RNA polymerase II promoter
  • defense response to virus
  • multicellular organismal development
  • defense response to protozoan
  • B cell proliferation
  • response to lipopolysaccharide
  • inflammatory response
  • positive regulation of isotype switching to IgG isotypes
  • positive regulation of GTPase activity
  • positive regulation of tyrosine phosphorylation of Stat1 protein
  • protein kinase B signaling
  • platelet activation
  • cellular response to lipopolysaccharide
  • protein complex assembly
  • cellular calcium ion homeostasis
  • positive regulation of endothelial cell apoptotic process
  • positive regulation of MAP kinase activity
  • positive regulation of protein phosphorylation
  • regulation of immunoglobulin secretion
  • apoptotic signaling pathway
  • regulation of cell proliferation
  • immune response-regulating cell surface receptor signaling pathway
  • positive regulation of protein kinase C signaling
  • tumor necrosis factor-mediated signaling pathway
  • cytoplasm
  • intracellular membrane-bounded organelle
  • plasma membrane
  • extracellular space
  • cell surface
  • CD40 receptor complex
  • extracellular exosome
  • external side of plasma membrane
  • integral component of plasma membrane
General FunctionUbiquitin protein ligase binding
Specific FunctionReceptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.
Pfam Domain Function
Transmembrane Regions194-215
GenBank Protein ID29851
UniProtKB IDP25942
UniProtKB Entry NameTNR5_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0016348|Tumor necrosis factor receptor superfamily member 5 (CD40)
GenBank Gene IDX60592
GeneCard IDNot Available
GenAtlas IDCD40
Chromosome Location20
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