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Calreticulin

NameCalreticulin
Synonyms
  • Calregulin
  • CRP55
  • CRTC
  • Endoplasmic reticulum resident protein 60
  • ERp60
  • grp60
  • HACBP
Gene NameCALR
OrganismHuman
Amino acid sequence
>lcl|BSEQ0011528|Calreticulin
MLLSVPLLLGLLGLAVAEPAVYFKEQFLDGDGWTSRWIESKHKSDFGKFVLSSGKFYGDE
EKDKGLQTSQDARFYALSASFEPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPNSLDQT
DMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRCKDDEFTHLYTLIVRPDN
TYEVKIDNSQVESGSLEDDWDFLPPKKIKDPDASKPEDWDERAKIDDPTDSKPEDWDKPE
HIPDPDAKKPEDWDEEMDGEWEPPVIQNPEYKGEWKPRQIDNPDYKGTWIHPEIDNPEYS
PDPSIYAYDNFGVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDK
QDEEQRLKEEEEDKKRKEEEEAEDKEDDEDKDEDEEDEEDKEEDEEEDVPGQAKDEL
Number of residues417
Molecular Weight48141.2
Theoretical pI4.04
GO Classification
Functions
  • DNA binding
  • hormone binding
  • poly(A) RNA binding
  • complement component C1q binding
  • glycoprotein binding
  • protein binding involved in protein folding
  • androgen receptor binding
  • carbohydrate binding
  • unfolded protein binding
  • iron ion binding
  • zinc ion binding
  • integrin binding
  • mRNA binding
  • peptide binding
  • calcium ion binding
  • chaperone binding
  • ubiquitin protein ligase binding
Processes
  • cellular calcium ion homeostasis
  • chaperone-mediated protein folding
  • protein localization to nucleus
  • protein maturation by protein folding
  • endoplasmic reticulum unfolded protein response
  • receptor-mediated endocytosis
  • response to testosterone
  • response to drug
  • positive regulation of gene expression
  • response to estradiol
  • positive regulation of cell cycle
  • cellular protein metabolic process
  • protein folding
  • post-translational protein modification
  • cell cycle arrest
  • spermatogenesis
  • cardiac muscle cell differentiation
  • protein N-linked glycosylation via asparagine
  • negative regulation of neuron differentiation
  • negative regulation of intracellular steroid hormone receptor signaling pathway
  • cellular senescence
  • positive regulation of cell proliferation
  • negative regulation of translation
  • negative regulation of transcription, DNA-templated
  • glucocorticoid receptor signaling pathway
  • antigen processing and presentation of exogenous peptide antigen via MHC class I
  • protein stabilization
  • negative regulation of retinoic acid receptor signaling pathway
  • positive regulation of phagocytosis
  • regulation of apoptotic process
  • peptide antigen assembly with MHC class I protein complex
  • cellular response to lithium ion
  • cortical actin cytoskeleton organization
  • positive regulation of dendritic cell chemotaxis
  • ATF6-mediated unfolded protein response
  • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
  • protein export from nucleus
  • negative regulation of transcription from RNA polymerase II promoter
  • protein folding in endoplasmic reticulum
  • antigen processing and presentation of peptide antigen via MHC class I
  • regulation of meiotic nuclear division
  • positive regulation of DNA replication
  • sequestering of calcium ion
  • regulation of transcription, DNA-templated
  • positive regulation of substrate adhesion-dependent cell spreading
Components
  • acrosomal vesicle
  • external side of plasma membrane
  • integral component of lumenal side of endoplasmic reticulum membrane
  • endoplasmic reticulum lumen
  • nucleus
  • focal adhesion
  • MHC class I peptide loading complex
  • endoplasmic reticulum
  • polysome
  • sarcoplasmic reticulum lumen
  • extracellular space
  • proteinaceous extracellular matrix
  • cell surface
  • Golgi apparatus
  • endocytic vesicle lumen
  • smooth endoplasmic reticulum
  • intracellular
  • cytosol
  • cytoplasm
  • extracellular exosome
  • membrane
  • perinuclear region of cytoplasm
  • extracellular region
General FunctionZinc ion binding
Specific FunctionCalcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID337487
UniProtKB IDP27797
UniProtKB Entry NameCALR_HUMAN
Cellular LocationEndoplasmic reticulum lumen
Gene sequence
>lcl|BSEQ0011529|Calreticulin (CALR)
ATGCTGCTATCCGTGCCGCTGCTGCTCGGCCTCCTCGGCCTGGCCGTCGCCGAGCCTGCC
GTCTACTTCAAGGAGCAGTTTCTGGACGGAGACGGGTGGACTTCCCGCTGGATCGAATCC
AAACACAAGTCAGATTTTGGCAAATTCGTTCTCAGTTCCGGCAAGTTCTACGGTGACGAG
GAGAAAGATAAAGGTTTGCAGACAAGCCAGGATGCACGCTTTTATGCTCTGTCGGCCAGT
TTCGAGCCTTTCAGCAACAAAGGCCAGACGCTGGTGGTGCAGTTCACGGTGAAACATGAG
CAGAACATCGACTGTGGGGGCGGCTATGTGAAGCTGTTTCCTAATAGTTTGGACCAGACA
GACATGCACGGAGACTCAGAATACAACATCATGTTTGGTCCCGACATCTGTGGCCCTGGC
ACCAAGAAGGTTCATGTCATCTTCAACTACAAGGGCAAGAACGTGCTGATCAACAAGGAC
ATCCGTTGCAAGGATGATGAGTTTACACACCTGTACACACTGATTGTGCGGCCAGACAAC
ACCTATGAGGTGAAGATTGACAACAGCCAGGTGGAGTCCGGCTCCTTGGAAGACGATTGG
GACTTCCTGCCACCCAAGAAGATAAAGGATCCTGATGCTTCAAAACCGGAAGACTGGGAT
GAGCGGGCCAAGATCGATGATCCCACAGACTCCAAGCCTGAGGACTGGGACAAGCCCGAG
CATATCCCTGACCCTGATGCTAAGAAGCCCGAGGACTGGGATGAAGAGATGGACGGAGAG
TGGGAACCCCCAGTGATTCAGAACCCTGAGTACAAGGGTGAGTGGAAGCCCCGGCAGATC
GACAACCCAGATTACAAGGGCACTTGGATCCACCCAGAAATTGACAACCCCGAGTATTCT
CCCGATCCCAGTATCTATGCCTATGATAACTTTGGCGTGCTGGGCCTGGACCTCTGGCAG
GTCAAGTCTGGCACCATCTTTGACAACTTCCTCATCACCAACGATGAGGCATACGCTGAG
GAGTTTGGCAACGAGACGTGGGGCGTAACAAAGGCAGCAGAGAAACAAATGAAGGACAAA
CAGGACGAGGAGCAGAGGCTTAAGGAGGAGGAAGAAGACAAGAAACGCAAAGAGGAGGAG
GAGGCAGAGGACAAGGAGGATGATGAGGACAAAGATGAGGATGAGGAGGATGAGGAGGAC
AAGGAGGAAGATGAGGAGGAAGATGTCCCCGGCCAGGCCAAGGACGAGCTGTAG
GenBank Gene IDM32294
GeneCard IDNot Available
GenAtlas IDCALR
HGNC IDHGNC:1455
Chromosome Location19
Locus19p13.3-p13.2
References
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