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NameMitogen-activated protein kinase 1
  • ERK-2
  • ERK2
  • ERT1
  • Extracellular signal-regulated kinase 2
  • MAP kinase 1
  • MAP kinase 2
  • MAP kinase isoform p42
  • MAPK 2
  • Mitogen-activated protein kinase 2
  • p42-MAPK
  • PRKM1
  • PRKM2
Gene NameMAPK1
Amino acid sequence
>lcl|BSEQ0001838|Mitogen-activated protein kinase 1
Number of residues360
Molecular Weight41389.265
Theoretical pI6.99
GO Classification
  • MAP kinase activity
  • ATP binding
  • protein serine/threonine kinase activity
  • phosphatase binding
  • RNA polymerase II carboxy-terminal domain kinase activity
  • DNA binding
  • innate immune response
  • caveolin-mediated endocytosis
  • trachea formation
  • response to estrogen
  • regulation of early endosome to late endosome transport
  • Fc-epsilon receptor signaling pathway
  • cellular response to granulocyte macrophage colony-stimulating factor stimulus
  • TRIF-dependent toll-like receptor signaling pathway
  • JAK-STAT cascade involved in growth hormone signaling pathway
  • regulation of Golgi inheritance
  • positive regulation of cell migration
  • cellular response to heat
  • small GTPase mediated signal transduction
  • sensory perception of pain
  • regulation of protein stability
  • positive regulation of transcription, DNA-templated
  • cytosine metabolic process
  • synaptic transmission
  • regulation of sequence-specific DNA binding transcription factor activity
  • ERBB signaling pathway
  • cell cycle
  • negative regulation of cell differentiation
  • response to epidermal growth factor
  • activation of MAPKK activity
  • lung morphogenesis
  • chemotaxis
  • viral process
  • response to toxic substance
  • response to exogenous dsRNA
  • apoptotic process
  • mammary gland epithelial cell proliferation
  • response to stress
  • lipopolysaccharide-mediated signaling pathway
  • stress-activated MAPK cascade
  • fibroblast growth factor receptor signaling pathway
  • MAPK import into nucleus
  • platelet activation
  • long-term synaptic potentiation
  • toll-like receptor 10 signaling pathway
  • insulin receptor signaling pathway
  • MyD88-dependent toll-like receptor signaling pathway
  • positive regulation of translation
  • transcription, DNA-templated
  • toll-like receptor 2 signaling pathway
  • signal transduction
  • MAPK cascade
  • MyD88-independent toll-like receptor signaling pathway
  • regulation of stress-activated MAPK cascade
  • activation of MAPK activity
  • toll-like receptor 3 signaling pathway
  • neurotrophin TRK receptor signaling pathway
  • positive regulation of peptidyl-threonine phosphorylation
  • peptidyl-threonine phosphorylation
  • toll-like receptor 4 signaling pathway
  • toll-like receptor 5 signaling pathway
  • protein phosphorylation
  • positive regulation of telomerase activity
  • ERK1 and ERK2 cascade
  • T cell receptor signaling pathway
  • peptidyl-serine phosphorylation
  • toll-like receptor 9 signaling pathway
  • Ras protein signal transduction
  • positive regulation of telomere capping
  • axon guidance
  • B cell receptor signaling pathway
  • toll-like receptor signaling pathway
  • vascular endothelial growth factor receptor signaling pathway
  • positive regulation of telomere maintenance via telomerase
  • cellular response to DNA damage stimulus
  • toll-like receptor TLR1
  • blood coagulation
  • labyrinthine layer blood vessel development
  • regulation of cellular response to heat
  • epidermal growth factor receptor signaling pathway
  • toll-like receptor TLR6
  • positive regulation of cell proliferation
  • regulation of cytoskeleton organization
  • Fc-gamma receptor signaling pathway involved in phagocytosis
  • nucleus
  • perikaryon
  • late endosome
  • axon
  • caveola
  • pseudopodium
  • early endosome
  • cytoplasm
  • microtubule organizing center
  • mitochondrion
  • focal adhesion
  • protein complex
  • Golgi apparatus
  • cytosol
  • extracellular exosome
  • dendrite cytoplasm
  • nucleoplasm
  • cytoskeleton
  • microtubule cytoskeleton
  • mitotic spindle
General FunctionRna polymerase ii carboxy-terminal domain kinase activity
Specific FunctionSerine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in respons to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation.Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID182191
UniProtKB IDP28482
UniProtKB Entry NameMK01_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0010648|Mitogen-activated protein kinase 1 (MAPK1)
GenBank Gene IDM84489
GeneCard IDNot Available
GenAtlas IDMAPK1
Chromosome Location22
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