Peptidyl-prolyl cis-trans isomerase F, mitochondrial

NamePeptidyl-prolyl cis-trans isomerase F, mitochondrial
Synonyms
  • 5.2.1.8
  • Cyclophilin D
  • Cyclophilin F
  • CyP-D
  • CyP-M
  • CYP3
  • CypD
  • Mitochondrial cyclophilin
  • PPIase F
  • Rotamase F
Gene NamePPIF
OrganismHuman
Amino acid sequence
>lcl|BSEQ0002777|Peptidyl-prolyl cis-trans isomerase F, mitochondrial
MLALRCGSRWLGLLSVPRSVPLRLPAARACSKGSGDPSSSSSSGNPLVYLDVDANGKPLG
RVVLELKADVVPKTAENFRALCTGEKGFGYKGSTFHRVIPSFMCQAGDFTNHNGTGGKSI
YGSRFPDENFTLKHVGPGVLSMANAGPNTNGSQFFICTIKTDWLDGKHVVFGHVKEGMDV
VKKIESFGSKSGRTSKKIVITDCGQLS
Number of residues207
Molecular Weight22040.09
Theoretical pI9.95
GO Classification
Functions
  • peptidyl-prolyl cis-trans isomerase activity
  • cyclosporin A binding
Processes
  • positive regulation of release of cytochrome c from mitochondria
  • apoptotic mitochondrial changes
  • protein peptidyl-prolyl isomerization
  • response to ischemia
  • negative regulation of release of cytochrome c from mitochondria
  • cellular response to arsenic-containing substance
  • regulation of necrotic cell death
  • negative regulation of ATPase activity
  • regulation of mitochondrial membrane permeability
  • protein folding
  • negative regulation of oxidative phosphorylation
  • necroptotic process
  • negative regulation of oxidative phosphorylation uncoupler activity
  • negative regulation of apoptotic process
  • regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
  • cellular response to calcium ion
  • cellular response to hydrogen peroxide
  • regulation of proton-transporting ATPase activity, rotational mechanism
  • negative regulation of intrinsic apoptotic signaling pathway
Components
  • mitochondrion
  • membrane
  • mitochondrial inner membrane
  • mitochondrial matrix
General FunctionPeptidyl-prolyl cis-trans isomerase activity
Specific FunctionPPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID181274
UniProtKB IDP30405
UniProtKB Entry NamePPIF_HUMAN
Cellular LocationMitochondrion matrix
Gene sequence
>lcl|BSEQ0021846|Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIF)
ATGCTGGCGCTGCGCTGCGGCTCCCGCTGGCTCGGCCTGCTCTCCGTCCCGCGCTCCGTG
CCGCTGCGCCTCCCCGCGGCCCGCGCCTGCAGCAAGGGCTCCGGCGACCCGTCCTCTTCC
TCCTCCTCCGGGAACCCGCTCGTGTACCTGGACGTGGACGCCAACGGGAAGCCGCTCGGC
CGCGTGGTGCTGGAGCTGAAGGCAGATGTCGTCCCAAAGACAGCTGAGAACTTCAGAGCC
CTGTGCACTGGTGAGAAGGGCTTCGGCTACAAAGGCTCCACCTTCCACAGGGTGATCCCT
TCCTTCATGTGCCAGGCGGGCGACTTCACCAACCACAATGGCACAGGCGGGAAGTCCATC
TACGGAAGCCGCTTTCCTGACGAGAACTTTACACTGAAGCACGTGGGGCCAGGTGTCCTG
TCCATGGCTAATGCTGGTCCTAACACCAACGGCTCCCAGTTCTTCATCTGCACCATAAAG
ACAGACTGGTTGGATGGCAAGCATGTTGTGTTCGGTCACGTCAAAGAGGGCATGGACGTC
GTGAAGAAAATAGAATCTTTCGGCTCTAAGAGTGGGAGGACATCCAAGAAGATTGTCATC
ACAGACTGTGGCCAGTTGAGCTAA
GenBank Gene IDM80254
GeneCard IDNot Available
GenAtlas IDPPIF
HGNC IDHGNC:9259
Chromosome Location10
Locus10q22-q23
References
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