NameMelanocortin receptor 4
Synonyms
  • MC4-R
Gene NameMC4R
OrganismHuman
Amino acid sequence
>lcl|BSEQ0019822|Melanocortin receptor 4
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
Number of residues332
Molecular Weight36942.325
Theoretical pINot Available
GO Classification
Functions
  • neuropeptide binding
  • melanocyte-stimulating hormone receptor activity
  • melanocortin receptor activity
  • ubiquitin protein ligase binding
  • peptide hormone binding
Processes
  • diet induced thermogenesis
  • feeding behavior
  • insulin secretion
  • positive regulation of bone resorption
  • regulation of grooming behavior
  • negative regulation of feeding behavior
  • energy reserve metabolic process
  • positive regulation of cAMP biosynthetic process
  • response to insulin
  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway
Components
  • nucleus
  • plasma membrane
  • integral component of membrane
General FunctionUbiquitin protein ligase binding
Specific FunctionReceptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).
Pfam Domain Function
Transmembrane Regions44-69 82-106 124-145 166-186 192-215 249-271 281-304
GenBank Protein IDNot Available
UniProtKB IDP32245
UniProtKB Entry NameMC4R_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0019823|Melanocortin receptor 4 (MC4R)
ATGGTGAACTCCACCCACCGTGGGATGCACACTTCTCTGCACCTCTGGAACCGCAGCAGT
TACAGACTGCACAGCAATGCCAGTGAGTCCCTTGGAAAAGGCTACTCTGATGGAGGGTGC
TACGAGCAACTTTTTGTCTCTCCTGAGGTGTTTGTGACTCTGGGTGTCATCAGCTTGTTG
GAGAATATCTTAGTGATTGTGGCAATAGCCAAGAACAAGAATCTGCATTCACCCATGTAC
TTTTTCATCTGCAGCTTGGCTGTGGCTGATATGCTGGTGAGCGTTTCAAATGGATCAGAA
ACCATTGTCATCACCCTATTAAACAGTACAGATACGGATGCACAGAGTTTCACAGTGAAT
ATTGATAATGTCATTGACTCGGTGATCTGTAGCTCCTTGCTTGCATCCATTTGCAGCCTG
CTTTCAATTGCAGTGGACAGGTACTTTACTATCTTCTATGCTCTCCAGTACCATAACATT
ATGACAGTTAAGCGGGTTGGGATCATCATAAGTTGTATCTGGGCAGCTTGCACGGTTTCA
GGCATTTTGTTCATCATTTACTCAGATAGTAGTGCTGTCATCATCTGCCTCATCACCATG
TTCTTCACCATGCTGGCTCTCATGGCTTCTCTCTATGTCCACATGTTCCTGATGGCCAGG
CTTCACATTAAGAGGATTGCTGTCCTCCCCGGCACTGGTGCCATCCGCCAAGGTGCCAAT
ATGAAGGGAGCGATTACCTTGACCATCCTGATTGGCGTCTTTGTTGTCTGCTGGGCCCCA
TTCTTCCTCCACTTAATATTCTACATCTCTTGTCCTCAGAATCCATATTGTGTGTGCTTC
ATGTCTCACTTTAACTTGTATCTCATACTGATCATGTGTAATTCAATCATCGATCCTCTG
ATTTATGCACTCCGGAGTCAAGAACTGAGGAAAACCTTCAAAGAGATCATCTGTTGCTAT
CCCCTGGGAGGCCTTTGTGACTTGTCTAGCAGATATTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:6932
Chromosome Location18
LocusNot Available
References
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  2. Mountjoy KG, Mortrud MT, Low MJ, Simerly RB, Cone RD: Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol Endocrinol. 1994 Oct;8(10):1298-308. 7854347
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