NameMannosyl-oligosaccharide 1,2-alpha-mannosidase IA
Synonyms
  • 3.2.1.113
  • Alpha-1,2-mannosidase IA
  • Man(9)-alpha-mannosidase
  • Man9-mannosidase
  • Mannosidase alpha class 1A member 1
  • Processing alpha-1,2-mannosidase IA
Gene NameMAN1A1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009460|Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA
MPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIF
FLPDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDN
LARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPI
GVESREPADAAIREKRAKIKEMMKHAWNNYKGYAWGLNELKPISKGGHSSSLFGNIKGAT
IVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEEI
FRKKAVELGVKLLPAFHTPSGIPWALLNMKSGIGRNWPWASGGSSILAEFGTLHLEFMHL
SHLSGNPIFAEKVMNIRTVLNKLEKPQGLYPNYLNPSSGQWGQHHVSVGGLGDSFYEYLL
KAWLMSDKTDLEAKKMYFDAVQAIETHLIRKSSSGLTYIAEWKGGLLEHKMGHLTCFAGG
MFALGADAAPEGMAQHYLELGAEIARTCHESYNRTFMKLGPEAFRFDGGVEAIATRQNEK
YYILRPEVMETYMYMWRLTHDPKYRKWAWEAVEALENHCRVNGGYSGLRDVYLLHESYDD
VQQSFFLAETLKYLYLIFSDDDLLPLEHWIFNSEAHLLPILPKDKKEVEIREE
Number of residues653
Molecular Weight72967.88
Theoretical pINot Available
GO Classification
Functions
  • calcium ion binding
  • mannosidase activity
  • mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
Processes
  • cellular protein metabolic process
  • post-translational protein modification
  • protein N-linked glycosylation via asparagine
  • N-glycan processing
Components
  • endoplasmic reticulum
  • Golgi apparatus
  • integral component of membrane
  • extracellular exosome
  • Golgi membrane
  • endoplasmic reticulum-Golgi intermediate compartment
  • cytoplasm
  • membrane
General FunctionMannosyl-oligosaccharide 1,2-alpha-mannosidase activity
Specific FunctionInvolved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).
Pfam Domain Function
Transmembrane Regions42-62
GenBank Protein IDNot Available
UniProtKB IDP33908
UniProtKB Entry NameMA1A1_HUMAN
Cellular LocationGolgi apparatus membrane
Gene sequence
>lcl|BSEQ0013174|Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (MAN1A1)
ATGCCCGTGGGGGGCCTGTTGCCGCTCTTCAGCAGCCCCGCGGGCGGCGTCCTGGGCGGG
GGGCTCGGCGGCGGCGGTGGCAGGAAGGGGTCGGGCCCCGCCGCCCTCCGCCTGACGGAG
AAGTTCGTGCTGCTGCTGGTATTCAGCGCCTTCATCACGCTCTGCTTCGGGGCGATCTTC
TTCCTGCCAGACTCCTCCAAGCTGCTCAGCGGGGTCCTGTTCCACTCCAGCCCCGCCTTG
CAGCCGGCCGCCGACCACAAGCCCGGGCCCGGGGCGCGCGCCGAGGACGCGGCCGAGGGG
CGAGCCCGGCGCCGCGAGGAGGGGGCACCCGGGGACCCGGAGGCCGCCCTGGAGGACAAC
TTGGCCAGGATCCGCGAAAACCACGAGCGGGCTCTCAGGGAAGCCAAGGAGACCCTGCAG
AAGCTGCCCGAGGAGATCCAAAGAGACATCCTACTGGAGAAGAAGAAGGTGGCCCAGGAC
CAGCTGCGTGACAAGGCGCCGTTCAGAGGCCTGCCCCCGGTGGACTTCGTGCCCCCAATC
GGGGTGGAGAGCCGGGAGCCCGCCGACGCCGCCATCCGCGAGAAAAGGGCAAAGATCAAA
GAGATGATGAAACATGCTTGGAATAATTATAAAGGTTATGCCTGGGGATTAAATGAACTC
AAACCTATATCAAAAGGAGGCCATTCAAGCAGTTTGTTTGGTAACATCAAAGGAGCAACT
ATAGTAGATGCCCTGGATACACTTTTTATTATGGAAATGAAACATGAATTTGAAGAAGCA
AAATCATGGGTTGAAGAAAATTTAGATTTTAATGTGAATGCTGAAATTTCTGTCTTTGAA
GTAAATATACGCTTTGTTGGTGGACTACTCTCAGCCTACTATCTGTCTGGAGAAGAGATT
TTTCGAAAGAAAGCAGTGGAACTTGGGGTAAAATTGCTACCTGCATTTCATACTCCCTCT
GGAATACCTTGGGCATTGCTGAATATGAAAAGTGGTATTGGAAGGAACTGGCCCTGGGCC
TCTGGAGGCAGCAGTATTCTGGCAGAATTTGGAACCCTGCATTTGGAGTTTATGCACTTG
AGCCACTTATCAGGAAACCCCATCTTTGCTGAAAAGGTAATGAATATTCGAACAGTACTG
AACAAACTGGAAAAACCACAAGGCCTTTATCCTAACTATCTGAATCCCAGTAGTGGACAG
TGGGGTCAACATCATGTATCAGTTGGAGGACTTGGAGACAGCTTCTATGAGTATTTGCTG
AAGGCCTGGTTAATGTCTGACAAGACAGATCTGGAAGCTAAGAAGATGTATTTTGATGCT
GTTCAGGCTATCGAGACTCATTTGATCCGCAAGTCTAGCAGCGGACTAACTTATATCGCA
GAGTGGAAAGGGGGCCTCCTGGAGCACAAGATGGGCCACCTGACCTGCTTCGCGGGGGGC
ATGTTCGCACTCGGGGCTGATGCAGCTCCCGAAGGCATGGCCCAACACTACCTTGAACTC
GGGGCTGAAATTGCCCGTACTTGTCATGAATCATATAATCGAACATTTATGAAACTGGGA
CCAGAAGCTTTCAGATTTGATGGTGGTGTTGAAGCCATCGCTACAAGACAAAATGAAAAA
TACTACATCTTACGGCCAGAAGTTATGGAGACTTACATGTATATGTGGAGACTGACTCAT
GATCCAAAGTACAGGAAATGGGCCTGGGAAGCCGTAGAGGCCTTGGAAAACCATTGCAGA
GTGAATGGAGGCTATTCAGGCCTAAGGGATGTTTACCTTCTTCATGAGAGTTATGATGAT
GTGCAGCAGAGTTTCTTCCTGGCAGAGACATTGAAATATTTGTACCTAATATTTTCTGAC
GACGATCTTCTTCCACTGGAGCATTGGATCTTCAATAGCGAGGCACATCTTCTCCCTATC
CTCCCTAAAGATAAAAAGGAAGTTGAAATCAGAGAGGAATAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:6821
Chromosome Location6
LocusNot Available
References
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