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NameProstaglandin G/H synthase 2
Synonyms
  • 1.14.99.1
  • COX-2
  • COX2
  • Cyclooxygenase-2
  • PGH synthase 2
  • PGHS-2
  • PHS II
  • Prostaglandin H2 synthase 2
  • Prostaglandin-endoperoxide synthase 2
Gene NamePTGS2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0021832|Prostaglandin G/H synthase 2
MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFL
TRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADY
GYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGS
NMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKY
QIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCD
VLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQ
NRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRV
AGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEAL
YGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEV
GFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKER
STEL
Number of residues604
Molecular Weight68995.625
Theoretical pI7.41
GO Classification
Functions
  • prostaglandin-endoperoxide synthase activity
  • peroxidase activity
  • lipid binding
  • metal ion binding
  • arachidonate 15-lipoxygenase activity
  • enzyme binding
  • heme binding
Processes
  • brown fat cell differentiation
  • positive regulation of prostaglandin biosynthetic process
  • response to estradiol
  • negative regulation of smooth muscle contraction
  • negative regulation of calcium ion transport
  • positive regulation of vasoconstriction
  • negative regulation of cell proliferation
  • positive regulation of smooth muscle contraction
  • positive regulation of brown fat cell differentiation
  • response to vitamin D
  • positive regulation of smooth muscle cell proliferation
  • regulation of inflammatory response
  • maintenance of blood-brain barrier
  • decidualization
  • ovulation
  • cellular response to hypoxia
  • NAD metabolic process
  • positive regulation of synaptic plasticity
  • cyclooxygenase pathway
  • prostaglandin metabolic process
  • memory
  • vitamin metabolic process
  • negative regulation of synaptic transmission, dopaminergic
  • negative regulation of cell cycle
  • response to drug
  • positive regulation of nitric oxide biosynthetic process
  • positive regulation of vascular endothelial growth factor production
  • water-soluble vitamin metabolic process
  • hair cycle
  • positive regulation of synaptic transmission, glutamatergic
  • arachidonic acid metabolic process
  • positive regulation of fibroblast growth factor production
  • response to oxidative stress
  • cellular response to fluid shear stress
  • lipoxygenase pathway
  • response to glucocorticoid
  • positive regulation of platelet-derived growth factor production
  • positive regulation of NF-kappaB import into nucleus
  • regulation of blood pressure
  • response to lipopolysaccharide
  • inflammatory response
  • response to tumor necrosis factor
  • response to manganese ion
  • sensory perception of pain
  • positive regulation of transforming growth factor beta production
  • nicotinamide metabolic process
  • bone mineralization
  • cellular response to ATP
  • small molecule metabolic process
  • prostaglandin biosynthetic process
  • embryo implantation
  • angiogenesis
  • positive regulation of apoptotic process
  • positive regulation of cell migration involved in sprouting angiogenesis
  • response to lithium ion
  • movement of cell or subcellular component
  • response to fructose
  • response to fatty acid
  • positive regulation of fever generation
  • learning
  • cellular response to mechanical stimulus
  • cellular response to UV
Components
  • cytoplasm
  • protein complex
  • nucleus
  • endoplasmic reticulum
  • neuron projection
  • endoplasmic reticulum membrane
  • caveola
  • endoplasmic reticulum lumen
General FunctionProstaglandin-endoperoxide synthase activity
Specific FunctionConverts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID291988
UniProtKB IDP35354
UniProtKB Entry NamePGH2_HUMAN
Cellular LocationMicrosome membrane
Gene sequence
>lcl|BSEQ0021833|Prostaglandin G/H synthase 2 (PTGS2)
ATGCTCGCCCGCGCCCTGCTGCTGTGCGCGGTCCTGGCGCTCAGCCATACAGCAAATCCT
TGCTGTTCCCACCCATGTCAAAACCGAGGTGTATGTATGAGTGTGGGATTTGACCAGTAT
AAGTGCGATTGTACCCGGACAGGATTCTATGGAGAAAACTGCTCAACACCGGAATTTTTG
ACAAGAATAAAATTATTTCTGAAACCCACTCCAAACACAGTGCACTACATACTTACCCAC
TTCAAGGGATTTTGGAACGTTGTGAATAACATTCCCTTCCTTCGAAATGCAATTATGAGT
TATGTGTTGACATCCAGATCACATTTGATTGACAGTCCACCAACTTACAATGCTGACTAT
GGCTACAAAAGCTGGGAAGCCTTCTCTAACCTCTCCTATTATACTAGAGCCCTTCCTCCT
GTGCCTGATGATTGCCCGACTCCCTTGGGTGTCAAAGGTAAAAAGCAGCTTCCTGATTCA
AATGAGATTGTGGAAAAATTGCTTCTAAGAAGAAAGTTCATCCCTGATCCCCAGGGCTCA
AACATGATGTTTGCATTCTTTGCCCAGCACTTCACGCATCAGTTTTTCAAGACAGATCAT
AAGCGAGGGCCAGCTTTCACCAACGGGCTGGGCCATGGGGTGGACTTAAATCATATTTAC
GGTGAAACTCTGGCTAGACAGCGTAAACTGCGCCTTTTCAAGGATGGAAAAATGAAATAT
CAGATAATTGATGGAGAGATGTATCCTCCCACAGTCAAAGATACTCAGGCAGAGATGATC
TACCCTCCTCAAGTCCCTGAGCATCTACGGTTTGCTGTGGGGCAGGAGGTCTTTGGTCTG
GTGCCTGGTCTGATGATGTATGCCACAATCTGGCTGCGGGAACACAACAGAGTATGCGAT
GTGCTTAAACAGGAGCATCCTGAATGGGGTGATGAGCAGTTGTTCCAGACAAGCAGGCTA
ATACTGATAGGAGAGACTATTAAGATTGTGATTGAAGATTATGTGCAACACTTGAGTGGC
TATCACTTCAAACTGAAATTTGACCCAGAACTACTTTTCAACAAACAATTCCAGTACCAA
AATCGTATTGCTGCTGAATTTAACACCCTCTATCACTGGCATCCCCTTCTGCCTGACACC
TTTCAAATTCATGACCAGAAATACAACTATCAACAGTTTATCTACAACAACTCTATATTG
CTGGAACATGGAATTACCCAGTTTGTTGAATCATTCACCAGGCAAATTGCTGGCAGGGTT
GCTGGTGGTAGGAATGTTCCACCCGCAGTACAGAAAGTATCACAGGCTTCCATTGACCAG
AGCAGGCAGATGAAATACCAGTCTTTTAATGAGTACCGCAAACGCTTTATGCTGAAGCCC
TATGAATCATTTGAAGAACTTACAGGAGAAAAGGAAATGTCTGCAGAGTTGGAAGCACTC
TATGGTGACATCGATGCTGTGGAGCTGTATCCTGCCCTTCTGGTAGAAAAGCCTCGGCCA
GATGCCATCTTTGGTGAAACCATGGTAGAAGTTGGAGCACCATTCTCCTTGAAAGGACTT
ATGGGTAATGTTATATGTTCTCCTGCCTACTGGAAGCCAAGCACTTTTGGTGGAGAAGTG
GGTTTTCAAATCATCAACACTGCCTCAATTCAGTCTCTCATCTGCAATAACGTGAAGGGC
TGTCCCTTTACTTCATTCAGTGTTCCAGATCCAGAGCTCATTAAAACAGTCACCATCAAT
GCAAGTTCTTCCCGCTCCGGACTAGATGATATCAATCCCACAGTACTACTAAAAGAACGT
TCGACTGAACTGTAG
GenBank Gene IDL15326
GeneCard IDNot Available
GenAtlas IDPTGS2
HGNC IDHGNC:9605
Chromosome Location1
Locus1q25.2-q25.3
References
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  2. Hla T, Neilson K: Human cyclooxygenase-2 cDNA. Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7384-8. 1380156
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