NameATP synthase subunit gamma, mitochondrial
Synonyms
  • ATP5C
  • ATP5CL1
  • F-ATPase gamma subunit
Gene NameATP5C1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0007365|ATP synthase subunit gamma, mitochondrial
MFSRAGVAGLSAWTLQPQWIQVRNMATLKDITRRLKSIKNIQKITKSMKMVAAAKYARAE
RELKPARIYGLGSLALYEKADIKGPEDKKKHLLIGVSSDRGLCGAIHSSIAKQMKSEVAT
LTAAGKEVMLVGIGDKIRGILYRTHSDQFLVAFKEVGRKPPTFGDASVIALELLNSGYEF
DEGSIIFNKFRSVISYKTEEKPIFSLNTVASADSMSIYDDIDADVLQNYQEYNLANIIYY
SLKESTTSEQSARMTAMDNASKNASEMIDKLTLTFNRTRQAVITKELIEIISGAAALD
Number of residues298
Molecular Weight32995.665
Theoretical pI9.71
GO Classification
Functions
  • poly(A) RNA binding
  • proton-transporting ATPase activity, rotational mechanism
  • transmembrane transporter activity
  • proton-transporting ATP synthase activity, rotational mechanism
Processes
  • oxidative phosphorylation
  • mitochondrial ATP synthesis coupled proton transport
  • small molecule metabolic process
  • cellular metabolic process
  • respiratory electron transport chain
  • ATP biosynthetic process
Components
  • mitochondrial proton-transporting ATP synthase complex
  • mitochondrion
  • membrane
  • mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)
  • mitochondrial inner membrane
  • mitochondrial matrix
  • extracellular exosome
  • myelin sheath
General FunctionTransmembrane transporter activity
Specific FunctionMitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID665586
UniProtKB IDP36542
UniProtKB Entry NameATPG_HUMAN
Cellular LocationMitochondrion
Gene sequence
>lcl|BSEQ0012682|ATP synthase subunit gamma, mitochondrial (ATP5C1)
ATGTTCTCTCGCGCGGGTGTCGCTGGGCTGTCGGCCTGGACCTTGCAGCCGCAATGGATT
CAAGTTCGAAATATGGCAACTTTGAAAGATATCACCAGGAGACTAAAGTCCATCAAAAAC
ATCCAGAAAATTACCAAGTCTATGAAAATGGTAGCGGCAGCAAAATATGCCCGAGCTGAG
AGAGAGCTGAAACCAGCTCGAATATATGGATTGGGATCTTTAGCTCTGTATGAAAAAGCT
GATATCAAGGGGCCTGAAGACAAGAAGAAACACCTCCTTATTGGTGTGTCCTCAGATCGA
GGACTGTGTGGTGCTATTCATTCCTCCATTGCTAAACAGATGAAAAGCGAGGTTGCTACA
CTAACAGCAGCTGGGAAAGAAGTTATGCTTGTTGGAATTGGTGACAAAATCAGAGGCATA
CTTTATAGGACTCATTCTGACCAGTTTCTGGTGGCATTCAAAGAAGTGGGAAGAAAGCCC
CCCACTTTTGGAGATGCGTCAGTCATTGCCCTTGAATTACTAAATTCTGGATATGAATTT
GATGAAGGCTCCATCATCTTTAATAAATTCAGGTCTGTCATCTCCTATAAGACAGAAGAA
AAGCCCATCTTTTCCCTTAATACCGTTGCAAGTGCTGACAGCATGAGTATCTATGACGAT
ATTGATGCTGACGTGCTGCAAAATTACCAAGAATACAATCTGGCCAACATCATCTACTAC
TCTCTGAAGGAGTCCACCACTAGTGAGCAGAGTGCCAGGATGACAGCCATGGACAATGCC
AGCAAGAATGCTTCTGAGATGATTGACAAATTGACATTGACATTCAACCGTACCCGCCAA
GCTGTCATCACAAAAGAGTTGATTGAAATTATCTCTGGTGCTGCAGCTCTGGATTAA
GenBank Gene IDD16562
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:833
Chromosome Location10
Locus10p15.1
References
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