Phospholipid hydroperoxide glutathione peroxidase, mitochondrial

NamePhospholipid hydroperoxide glutathione peroxidase, mitochondrial
Synonyms
  • 1.11.1.12
  • Glutathione peroxidase 4
  • GPx-4
  • GSHPx-4
  • PHGPx
Gene NameGPX4
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037127|Phospholipid hydroperoxide glutathione peroxidase, mitochondrial
MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYR
GFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFA
AGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKFLIDKNGCVVKRY
GPMEEPLVIEKDLPHYF
Number of residues197
Molecular Weight22174.52
Theoretical pI8.41
GO Classification
Functions
  • glutathione peroxidase activity
  • phospholipid-hydroperoxide glutathione peroxidase activity
Processes
  • response to oxidative stress
  • small molecule metabolic process
  • oxidation-reduction process
  • multicellular organismal development
  • arachidonic acid metabolic process
  • lipoxygenase pathway
  • phospholipid metabolic process
  • spermatogenesis
  • chromatin organization
Components
  • mitochondrial inner membrane
  • cytosol
  • extracellular exosome
  • nuclear envelope
  • mitochondrion
  • nucleus
General FunctionPhospholipid-hydroperoxide glutathione peroxidase activity
Specific FunctionProtects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID825667
UniProtKB IDP36969
UniProtKB Entry NameGPX4_HUMAN
Cellular LocationMitochondrion
Gene sequence
>lcl|BSEQ0010793|Phospholipid hydroperoxide glutathione peroxidase, mitochondrial (GPX4)
ATGAGCCTCGGCCGCCTTTGCCGCCTACTGAAGCCGGCGCTGCTCTGTGGGGCTCTGGCC
GCGCCTGGCCTGGCCGGGACCATGTGCGCGTCCCGGGACGACTGGCGCTGTGCGCGCTCC
ATGCACGAGTTTTCCGCCAAGGACATCGACGGGCACATGGTTAACCTGGACAAGTACCGG
GGCTTCGTGTGCATCGTCACCAACGTGGCCTCCCAGTGAGGCAAGACCGAAGTAAACTAC
ACTCAGCTCGTCGACCTGCACGCCCGATACGCTGAGTGTGGTTTGCGGATCCTGGCCTTC
CCGTGTAACCAGTTCGGGAAGCAGGAGCCAGGGAGTAACGAAGAGATCAAAGAGTTCGCC
GCGGGCTACAACGTCAAATTCGATATGTTCAGCAAGATCTGCGTGAACGGGGACGACGCC
CACCCGCTGTGGAAGTGGATGAAGATCCAACCCAAGGGCAAGGGCATCCTGGGAAATGCC
ATCAAGTGGAACTTCACCAAGTTTGGACACCGTCTCTCCACAGTTCCTCATCGACAAGAA
CGGCTGCGTGGTGAAGCGCTACGGACCCATGGAGGAGCCCCTGGTGATAGAGAAGGACCT
GCCCCACTATTTCTAGCTCCACAAGTGTGTGGCCCCGCCCGAGCCCCTGCCCACGCCCTT
GGAGCCTTCCACCGGCACTCATGA
GenBank Gene IDX71973
GeneCard IDNot Available
GenAtlas IDGPX4
HGNC IDHGNC:4556
Chromosome Location19
Locus19p13.3
References
  1. Esworthy RS, Doan K, Doroshow JH, Chu FF: Cloning and sequencing of the cDNA encoding a human testis phospholipid hydroperoxide glutathione peroxidase. Gene. 1994 Jul 8;144(2):317-8. 8039723
  2. Kelner MJ, Montoya MA: Structural organization of the human selenium-dependent phospholipid hydroperoxide glutathione peroxidase gene (GPX4): chromosomal localization to 19p13.3. Biochem Biophys Res Commun. 1998 Aug 10;249(1):53-5. 9705830
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