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NameSerine/threonine-protein kinase receptor R3
Synonyms
  • 2.7.11.30
  • Activin receptor-like kinase 1
  • ACVRLK1
  • ALK-1
  • ALK1
  • SKR3
  • TGF-B superfamily receptor type I
  • TSR-I
Gene NameACVRL1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0010321|Serine/threonine-protein kinase receptor R3
MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEG
RHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLA
LILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDS
DCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWF
RETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLAL
RLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSD
YLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVED
YRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARL
TALRIKKTLQKISNSPEKPKVIQ
Number of residues503
Molecular Weight56124.03
Theoretical pI7.64
GO Classification
Functions
  • transforming growth factor beta binding
  • ATP binding
  • protein serine/threonine kinase activity
  • protein kinase binding
  • receptor signaling protein serine/threonine kinase activity
  • transmembrane receptor protein serine/threonine kinase activity
  • metal ion binding
  • transforming growth factor beta-activated receptor activity
  • activin binding
  • activin receptor activity, type I
  • SMAD binding
Processes
  • cellular response to transforming growth factor beta stimulus
  • lymphatic endothelial cell differentiation
  • activin receptor signaling pathway
  • positive regulation of transcription, DNA-templated
  • negative regulation of blood vessel endothelial cell migration
  • BMP signaling pathway
  • negative regulation of cell proliferation
  • negative regulation of cell adhesion
  • cellular response to BMP stimulus
  • positive regulation of transcription from RNA polymerase II promoter
  • negative regulation of endothelial cell differentiation
  • positive regulation of pathway-restricted SMAD protein phosphorylation
  • protein phosphorylation
  • negative regulation of endothelial cell migration
  • signal transduction
  • regulation of blood pressure
  • blood circulation
  • negative regulation of endothelial cell proliferation
  • negative regulation of focal adhesion assembly
  • positive regulation of endothelial cell proliferation
  • angiogenesis
  • positive regulation of BMP signaling pathway
  • lymphangiogenesis
  • positive regulation of chondrocyte differentiation
  • wound healing, spreading of epidermal cells
  • retina vasculature development in camera-type eye
  • positive regulation of endothelial cell differentiation
  • negative regulation of cell growth
  • negative regulation of DNA biosynthetic process
  • negative regulation of cell migration
  • regulation of blood vessel endothelial cell migration
  • blood vessel remodeling
  • positive regulation of angiogenesis
  • regulation of endothelial cell proliferation
  • venous blood vessel development
  • transforming growth factor beta receptor signaling pathway
  • regulation of DNA replication
  • artery development
  • in utero embryonic development
  • blood vessel endothelial cell proliferation involved in sprouting angiogenesis
  • regulation of transcription, DNA-templated
  • blood vessel maturation
  • endothelial tube morphogenesis
Components
  • cell surface
  • integral component of plasma membrane
General FunctionTransmembrane receptor protein serine/threonine kinase activity
Specific FunctionType I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.
Pfam Domain Function
Transmembrane Regions119-141
GenBank Protein ID402197
UniProtKB IDP37023
UniProtKB Entry NameACVL1_HUMAN
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0010322|Serine/threonine-protein kinase receptor R3 (ACVRL1)
ATGACCTTGGGCTCCCCCAGGAAAGGCCTTCTGATGCTGCTGATGGCCTTGGTGACCCAG
GGAGACCCTGTGAAGCCGTCTCGGGGCCCGCTGGTGACCTGCACGTGTGAGAGCCCACAT
TGCAAGGGGCCTACCTGCCGGGGGGCCTGGTGCACAGTAGTGCTGGTGCGGGAGGAGGGG
AGGCACCCCCAGGAACATCGGGGCTGCGGGAACTTGCACAGGGAGCTCTGCAGGGGGCGC
CCCACCGAGTTCGTCAACCACTACTGCTGCGACAGCCACCTCTGCAACCACAACGTGTCC
CTGGTGCTGGAGGCCACCCAACCTCCTTCGGAGCAGCCGGGAACAGATGGCCAGCTGGCC
CTGATCCTGGGCCCCGTGCTGGCCTTGCTGGCCCTGGTGGCCCTGGGTGTCCTGGGCCTG
TGGCATGTCCGACGGAGGCAGGAGAAGCAGCGTGGCCTGCACAGCGAGCTGGGAGAGTCC
AGTCTCATCCTGAAAGCATCTGAGCAGGGCGACAGCATGTTGGGGGACCTCCTGGACAGT
GACTGCACCACAGGGAGTGGCTCAGGGCTCCCCTTCCTGGTGCAGAGGACAGTGGCACGG
CAGGTTGCCTTGGTGGAGTGTGTGGGAAAAGGCCGCTATGGCGAAGTGTGGCGGGGCTTG
TGGCACGGTGAGAGTGTGGCCGTCAAGATCTTCTCCTCGAGGGATGAACAGTCCTGGTTC
CGGGAGACTGAGATCTATAACACAGTGTTGCTCAGACACGACAACATCCTAGGCTTCATC
GCCTCAGACATGACCTCCCGCAACTCGAGCACGCAGCTGTGGCTCATCACGCACTACCAC
GAGCACGGCTCCCTCTACGACTTTCTGCAGAGACAGACGCTGGAGCCCCATCTGGCTCTG
AGGCTAGCTGTGTCCGCGGCATGCGGCCTGGCGCACCTGCACGTGGAGATCTTCGGTACA
CAGGGCAAACCAGCCATTGCCCACCGCGACTTCAAGAGCCGCAATGTGCTGGTCAAGAGC
AACCTGCAGTGTTGCATCGCCGACCTGGGCCTGGCTGTGATGCACTCACAGGGCAGCGAT
TACCTGGACATCGGCAACAACCCGAGAGTGGGCACCAAGCGGTACATGGCACCCGAGGTG
CTGGACGAGCAGATCCGCACGGACTGCTTTGAGTCCTACAAGTGGACTGACATCTGGGCC
TTTGGCCTGGTGCTGTGGGAGATTGCCCGCCGGACCATCGTGAATGGCATCGTGGAGGAC
TATAGACCACCCTTCTATGATGTGGTGCCCAATGACCCCAGCTTTGAGGACATGAAGAAG
GTGGTGTGTGTGGATCAGCAGACCCCCACCATCCCTAACCGGCTGGCTGCAGACCCGGTC
CTCTCAGGCCTAGCTCAGATGATGCGGGAGTGCTGGTACCCAAACCCCTCTGCCCGACTC
ACCGCGCTGCGGATCAAGAAGACACTACAAAAAATTAGCAACAGTCCAGAGAAGCCTAAA
GTGATTCAATAG
GenBank Gene IDZ22533
GeneCard IDNot Available
GenAtlas IDACVRL1
HGNC IDHGNC:175
Chromosome Location12
Locus12q11-q14
References
  1. ten Dijke P, Ichijo H, Franzen P, Schulz P, Saras J, Toyoshima H, Heldin CH, Miyazono K: Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity. Oncogene. 1993 Oct;8(10):2879-87. 8397373
  2. Attisano L, Carcamo J, Ventura F, Weis FM, Massague J, Wrana JL: Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors. Cell. 1993 Nov 19;75(4):671-80. 8242742
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