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Testosterone 17-beta-dehydrogenase 3
Name | Testosterone 17-beta-dehydrogenase 3 |
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Synonyms |
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Gene Name | HSD17B3 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0000669|Testosterone 17-beta-dehydrogenase 3 MGDVLEQFFILTGLLVCLACLAKCVRFSRCVLLNYWKVLPKSFLRSMGQWAVITGAGDGI GKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFTKDDIYEHIKEKL AGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKMTQLILKHMESRQKGLI LNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQVLTPYAVSTAMTKYLN TNVITKTADEFVKESLNYVTIGGETCGCLAHEILAGFLSLIPAWAFYSGAFQRLLLTHYV AYLKLNTKVR |
Number of residues | 310 |
Molecular Weight | 34515.345 |
Theoretical pI | 8.84 |
GO Classification | Functions
Processes
Components
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General Function | Testosterone 17-beta-dehydrogenase (nadp+) activity |
Specific Function | Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH. |
Pfam Domain Function |
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Transmembrane Regions | Not Available |
GenBank Protein ID | 531162 |
UniProtKB ID | P37058 |
UniProtKB Entry Name | DHB3_HUMAN |
Cellular Location | Not Available |
Gene sequence | >lcl|BSEQ0010251|Testosterone 17-beta-dehydrogenase 3 (HSD17B3) ATGGGGGACGTCCTGGAACAGTTCTTCATCCTCACAGGGCTGCTGGTGTGCCTGGCCTGC CTGGCGAAGTGCGTGAGATTCTCCAGATGTGTTTTACTGAACTACTGGAAAGTTTTGCCA AAGTCTTTCTTGCGGTCAATGGGACAGTGGGCAGTGATCACTGGAGCAGGCGATGGAATT GGGAAAGCGTACTCGTTCGAGCTAGCAAAACGTGGACTCAATGTTGTCCTTATTAGCCGG ACGCTGGAAAAACTAGAGGCCATTGCCACAGAGATCGAGCGGACTACAGGGAGGAGTGTG AAGATTATACAAGCAGATTTTACAAAAGATGACATCTACGAGCATATTAAAGAAAAACTT GCAGGCTTAGAAATTGGAATTTTAGTCAACAATGTCGGAATGCTTCCAAACCTTCTCCCA AGCCATTTCCTGAACGCACCGGATGAAATCCAGAGCCTCATCCATTGTAACATCACCTCC GTAGTCAAGATGACACAGCTAATTCTGAAACATATGGAATCAAGGCAGAAAGGTCTCATC CTGAACATTTCTTCTGGGATAGCCCTGTTTCCTTGGCCTCTCTACTCCATGTACTCAGCT TCCAAGGCGTTTGTGTGCGCATTTTCCAAGGCCCTGCAAGAGGAATATAAAGCAAAAGAA GTCATCATCCAGGTGCTGACCCCATATGCTGTCTCGACTGCAATGACAAAGTATCTAAAT ACAAATGTGATAACCAAGACTGCTGATGAGTTTGTCAAAGAGTCATTGAATTATGTCACA ATTGGAGGTGAAACCTGTGGCTGCCTTGCCCATGAAATCTTGGCGGGCTTTCTGAGCCTG ATCCCGGCCTGGGCCTTCTACAGCGGTGCCTTCCAAAGGCTGCTCCTGACACACTATGTG GCATACCTGAAGCTCAACACCAAGGTCAGGTAG |
GenBank Gene ID | U05659 |
GeneCard ID | Not Available |
GenAtlas ID | HSD17B3 |
HGNC ID | HGNC:5212 |
Chromosome Location | 9 |
Locus | 9q22 |
References |
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