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Kappa-type opioid receptor

NameKappa-type opioid receptor
Synonyms
  • K-OR-1
  • OPRK
Gene NameOPRK1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001260|Kappa-type opioid receptor
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRV
RNTVQDPAYLRDIDGMNKPV
Number of residues380
Molecular Weight42644.665
Theoretical pI7.79
GO Classification
Functions
  • dynorphin receptor activity
  • neuropeptide binding
  • opioid receptor activity
Processes
  • response to morphine
  • adenylate cyclase-inhibiting opioid receptor signaling pathway
  • positive regulation of potassium ion transmembrane transport
  • positive regulation of locomotion
  • behavioral response to cocaine
  • regulation of saliva secretion
  • phospholipase C-activating G-protein coupled receptor signaling pathway
  • eating behavior
  • locomotory behavior
  • opioid receptor signaling pathway
  • estrous cycle
  • regulation of energy homeostasis
  • response to estrogen
  • positive regulation of dopamine secretion
  • immune response
  • defense response to virus
  • sensory perception of pain
  • positive regulation of p38MAPK cascade
  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
  • neuropeptide signaling pathway
  • sensory perception of temperature stimulus
  • cellular response to lipopolysaccharide
  • synaptic transmission
  • response to acrylamide
  • response to insulin
  • response to radiation
  • behavior
  • maternal behavior
  • sensory perception
  • negative regulation of luteinizing hormone secretion
  • response to ethanol
  • regulation of aerobic respiration
  • regulation of sensory perception of pain
Components
  • integral component of plasma membrane
  • axon terminus
  • dendrite
  • synapse
  • neuron projection
  • perikaryon
  • plasma membrane
  • integral component of membrane
General FunctionOpioid receptor activity
Specific FunctionG-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
Pfam Domain Function
Transmembrane Regions58-85 96-119 133-154 174-196 223-247 275-296 312-333
GenBank Protein ID532060
UniProtKB IDP41145
UniProtKB Entry NameOPRK_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0021645|Kappa-type opioid receptor (OPRK1)
ATGGACTCCCCGATCCAGATCTTCCGCGGGGAGCCGGGCCCTACCTGCGCCCCGAGCGCC
TGCCTGCCCCCCAACAGCAGCGCCTGGTTTCCCGGCTGGGCCGAGCCCGACAGCAACGGC
AGCGCCGGCTCGGAGGACGCGCAGCTGGAGCCCGCGCACATCTCCCCGGCCATCCCGGTC
ATCATCACGGCGGTCTACTCCGTAGTGTTCGTCGTGGGCTTGGTGGGCAACTCGCTGGTC
ATGTTCGTGATCATCCGATACACAAAGATGAAGACAGCAACCAACATTTACATATTTAAC
CTGGCTTTGGCAGATGCTTTAGTTACTACAACCATGCCCTTTCAGAGTACGGTCTACTTG
ATGAATTCCTGGCCTTTTGGGGATGTGCTGTGCAAGATAGTAATTTCCATTGATTACTAC
AACATGTTCACCAGCATCTTCACCTTGACCATGATGAGCGTGGACCGCTACATTGCCGTG
TGCCACCCCGTGAAGGCTTTGGACTTCCGCACACCCTTGAAGGCAAAGATCATCAATATC
TGCATCTGGCTGCTGTCGTCATCTGTTGGCATCTCTGCAATAGTCCTTGGAGGCACCAAA
GTCAGGGAAGACGTCGATGTCATTGAGTGCTCCTTGCAGTTCCCAGATGATGACTACTCC
TGGTGGGACCTCTTCATGAAGATCTGCGTCTTCATCTTTGCCTTCGTGATCCCTGTCCTC
ATCATCATCGTCTGCTACACCCTGATGATCCTGCGTCTCAAGAGCGTCCGGCTCCTTTCT
GGCTCCCGAGAGAAAGATCGCAACCTGCGTAGGATCACCAGACTGGTCCTGGTGGTGGTG
GCAGTCTTCGTCGTCTGCTGGACTCCCATTCACATATTCATCCTGGTGGAGGCTCTGGGG
AGCACCTCCCACAGCACAGCTGCTCTCTCCAGCTATTACTTCTGCATCGCCTTAGGCTAT
ACCAACAGTAGCCTGAATCCCATTCTCTACGCCTTTCTTGATGAAAACTTCAAGCGGTGT
TTCCGGGACTTCTGCTTTCCACTGAAGATGAGGATGGAGCGGCAGAGCACTAGCAGAGTC
CGAAATACAGTTCAGGATCCTGCTTACCTGAGGGACATCGATGGGATGAATAAACCAGTA
TGA
GenBank Gene IDU11053
GeneCard IDNot Available
GenAtlas IDOPRK1
HGNC IDHGNC:8154
Chromosome Location8
Locus8q11.2
References
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