ATP-binding cassette sub-family G member 1

NameATP-binding cassette sub-family G member 1
Synonyms
  • ABC8
  • ATP-binding cassette transporter 8
  • White protein homolog
  • WHT1
Gene NameABCG1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0002323|ATP-binding cassette sub-family G member 1
MACLMAAFSVGTAMNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNL
TEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPS
GAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMV
SAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFF
DEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGK
VCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGD
AEVNPFLWHRPSEEVKQTKRLKGLRKDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDS
VLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLE
MGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAAL
GTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYIS
YVRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLYLDFIVLGIFFI
SLRLIAYFVLRYKIRAER
Number of residues678
Molecular Weight75591.275
Theoretical pI7.87
GO Classification
Functions
  • phospholipid transporter activity
  • glycoprotein transporter activity
  • protein homodimerization activity
  • sterol-transporting ATPase activity
  • toxin transporter activity
  • protein heterodimerization activity
  • ATP binding
  • phospholipid binding
  • cholesterol binding
  • protein dimerization activity
  • ADP binding
  • cholesterol transporter activity
Processes
  • response to lipid
  • cholesterol efflux
  • positive regulation of cholesterol biosynthetic process
  • cholesterol homeostasis
  • small molecule metabolic process
  • cholesterol metabolic process
  • intracellular cholesterol transport
  • lipoprotein metabolic process
  • regulation of transcription, DNA-templated
  • amyloid precursor protein catabolic process
  • detection of hormone stimulus
  • negative regulation of cholesterol storage
  • glycoprotein transport
  • negative regulation of macrophage derived foam cell differentiation
  • regulation of cholesterol esterification
  • phospholipid efflux
  • transmembrane transport
  • response to high density lipoprotein particle
  • phospholipid homeostasis
  • toxin transport
  • positive regulation of cholesterol efflux
  • reverse cholesterol transport
  • low-density lipoprotein particle remodeling
  • high-density lipoprotein particle remodeling
  • response to organic substance
Components
  • Golgi apparatus
  • integral component of membrane
  • nucleoplasm
  • external side of plasma membrane
  • integral component of plasma membrane
  • intracellular membrane-bounded organelle
  • Golgi membrane
  • mitochondrion
  • plasma membrane
  • recycling endosome
  • endosome
  • endoplasmic reticulum membrane
General FunctionToxin transporter activity
Specific FunctionTransporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages.
Pfam Domain Function
Transmembrane Regions427-445 457-477 507-525 534-555 568-586 650-669
GenBank Protein ID1160186
UniProtKB IDP45844
UniProtKB Entry NameABCG1_HUMAN
Cellular LocationEndoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0010816|ATP-binding cassette sub-family G member 1 (ABCG1)
ATGGCCTGTCTGATGGCCGCTTTCTCGGTCGGCACCGCCATGAATGCCAGCAGTTACTCT
GCAGAGATGACGGAGCCCAAGTCGGTGTGTGTCTCGGTGGATGAGGTGGTGTCCAGCAAC
ATGGAGGCCACTGAGACGGACCTGCTGAATGGACATCTGAAAAAAGTAGATAATAACCTC
ACGGAAGCCCAGCGCTTCTCCTCCTTGCCTCGGAGGGCAGCTGTGAACATTGAATTCAGG
GACCTTTCCTATTCGGTTCCTGAAGGACCCTGGTGGAGGAAGAAAGGATACAAGACCCTC
CTGAAAGGAATTTCCGGGAAGTTCAATAGTGGTGAGTTGGTGGCCATTATGGGTCCTTCC
GGGGCCGGGAAGTCCACGCTGATGAACATCCTGGCTGGATACAGGGAGACGGGCATGAAG
GGGGCCGTCCTCATCAACGGCCTGCCCCGGGACCTGCGCTGCTTCCGGAAGGTGTCCTGC
TACATCATGCAGGATGACATGCTGCTGCCGCATCTCACTGTGCAGGAGGCCATGATGGTG
TCGGCACATCTGAAGCTTCAGGAGAAGGATGAAGGCAGAAGGGAAATGGTCAAGGAGATA
CTGACAGCGCTGGGCTTGCTGTCTTGCGCCAACACGCGGACCGGGAGCCTGTCAGGTGGT
CAGCGCAAGCGCCTGGCCATCGCGCTGGAGCTGGTGAACAACCCTCCAGTCATGTTCTTC
GATGAGCCCACCAGCGGCCTGGACAGCGCCTCCTGCTTCCAGGTGGTCTCGCTGATGAAA
GGGCTCGCTCAAGGGGGTCGCTCCATCATTTGCACCATCCACCAGCCCAGCGCCAAACTC
TTCGAGCTGTTCGACCAGCTTTACGTCCTGAGTCAAGGACAATGTGTGTACCGGGGAAAA
GTCTGCAATCTTGTGCCATATTTGAGGGATTTGGGTCTGAACTGCCCAACCTACCACAAC
CCAGCAGATTTTGTCATGGAGGTTGCATCCGGCGAGTACGGTGATCAGAACAGTCGGCTG
GTGAGAGCGGTTCGGGAGGGCATGTGTGACTCAGACCACAAGAGAGACCTCGGGGGTGAT
GCCGAGGTGAACCCTTTTCTTTGGCACCGGCCCTCTGAAGAGGTAAAGCAGACAAAACGA
TTAAAGGGGTTGAGAAAGGACTCCTCGTCCATGGAAGGCTGCCACAGCTTCTCTGCCAGC
TGCCTCACGCAGTTCTGCATCCTCTTCAAGAGGACCTTCCTCAGCATCATGAGGGACTCG
GTCCTGACACACCTGCGCATCACCTCGCACATTGGGATCGGCCTCCTCATTGGCCTGCTG
TACTTGGGGATCGGGAACGAAGCCAAGAAGGTCTTGAGCAACTCCGGCTTCCTCTTCTTC
TCCATGCTGTTCCTCATGTTCGCGGCCCTCATGCCTACTGTTCTGACATTTCCCCTGGAG
ATGGGAGTCTTTCTTCGGGAACACCTGAACTACTGGTACAGCCTGAAGGCCTACTACCTG
GCCAAGACCATGGCAGACGTGCCCTTTCAGATCATGTTCCCAGTGGCCTACTGCAGCATC
GTGTACTGGATGACGTCGCAGCCGTCCGACGCCGTGCGCTTTGTGCTGTTTGCCGCGCTG
GGCACCATGACCTCCCTGGTGGCACAGTCCCTGGGCCTGCTGATCGGAGCCGCCTCCACG
TCCCTGCAGGTGGCCACTTTCGTGGGCCCAGTGACAGCCATCCCGGTGCTCCTGTTCTCG
GGGTTCTTCGTCAGCTTCGACACCATCCCCACGTACCTACAGTGGATGTCCTACATCTCC
TATGTCAGGTATGGGTTCGAAGGGGTCATCCTCTCCATCTATGGCTTAGACCGGGAAGAT
CTGCACTGTGACATCGACGAGACGTGCCACTTCCAGAAGTCGGAGGCCATCCTGCGGGAG
CTGGACGTGGAAAATGCCAAGCTGTACCTGGACTTCATCGTACTCGGGATTTTCTTCATC
TCCCTCCGCCTCATTGCCTATTTTGTCCTCAGGTACAAAATCCGGGCAGAGAGGTAA
GenBank Gene IDX91249
GeneCard IDNot Available
GenAtlas IDABCG1
HGNC IDHGNC:73
Chromosome Location21
LocusNot Available
References
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