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NameGlucosamine-6-phosphate isomerase 1
Synonyms
  • 3.5.99.6
  • GlcN6P deaminase 1
  • Glucosamine-6-phosphate deaminase 1
  • GNPDA 1
  • GNPI
  • HLN
  • KIAA0060
  • Oscillin
Gene NameGNPDA1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0003111|Glucosamine-6-phosphate isomerase 1
MKLIILEHYSQASEWAAKYIRNRIIQFNPGPEKYFTLGLPTGSTPLGCYKKLIEYYKNGD
LSFKYVKTFNMDEYVGLPRDHPESYHSFMWNNFFKHIDIHPENTHILDGNAVDLQAECDA
FEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVKTLAMDTILANARFFDGELTK
VPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCD
EDATLELKVKTVKYFKGLMLVHNKLVDPLYSIKEKETEKSQSSKKPYSD
Number of residues289
Molecular Weight32668.29
Theoretical pI6.91
GO Classification
Functions
  • hydrolase activity
  • glucosamine-6-phosphate deaminase activity
Processes
  • generation of precursor metabolites and energy
  • carbohydrate metabolic process
  • N-acetylglucosamine metabolic process
  • single fertilization
  • glucosamine catabolic process
Components
  • cytoplasm
  • extracellular exosome
General FunctionHydrolase activity
Specific FunctionSeems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID2935438
UniProtKB IDP46926
UniProtKB Entry NameGNPI1_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0020540|Glucosamine-6-phosphate isomerase 1 (GNPDA1)
ATGAAGCTCATCATCCTGGAGCACTATTCTCAGGCGAGCGAGTGGGCGGCTAAATACATC
AGGAACCGCATCATCCAGTTTAACCCAGGGCCAGAGAAGTACTTCACCCTGGGGCTCCCC
ACTGGGAGTACCCCACTTGGCTGCTACAAGAAGCTGATTGAATACTATAAGAATGGGGAC
CTGTCCTTTAAATATGTGAAGACCTTCAACATGGATGAGTACGTGGGCCTTCCTCGAGAC
CACCCGGAGAGTTACCACTCCTTCATGTGGAACAACTTCTTCAAGCACATTGACATCCAC
CCAGAAAACACCCACATTCTGGATGGGAATGCAGTCGACCTACAGGCAGAATGTGATGCC
TTTGAAGAGAAGATCAAGGCTGCAGGTGGGATCGAGCTATTTGTTGGAGGCATCGGCCCT
GATGGACACATTGCCTTCAACGAGCCAGGCTCCAGTCTGGTGTCCAGGACCCGTGTGAAG
ACGCTGGCCATGGATACCATCCTGGCCAATGCTAGGTTCTTCGATGGAGAACTCACCAAG
GTGCCCACCATGGCCTTGACGGTGGGGGTGGGCACTGTCATGGATGCTAGAGAGGTGATG
ATCCTTATCACAGGTGCTCACAAGGCATTTGCTCTGTACAAGGCCATCGAGGAGGGAGTG
AACCACATGTGGACCGTGTCTGCCTTCCAGCAGCATCCCCGCACCGTGTTTGTGTGTGAC
GAGGATGCCACCTTGGAGCTGAAAGTGAAGACTGTCAAGTATTTCAAAGGTTTAATGCTT
GTTCATAACAAGTTGGTGGACCCCTTGTACAGTATCAAAGAGAAAGAAACTGAGAAAAGC
CAATCTTCGAAGAAACCATACAGCGATTAG
GenBank Gene IDAF048826
GeneCard IDNot Available
GenAtlas IDGNPDA1
HGNC IDHGNC:4417
Chromosome Location5
Locus5q21
References
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  2. Shevchenko V, Hogben M, Ekong R, Parrington J, Lai FA: The human glucosamine-6-phosphate deaminase gene: cDNA cloning and expression, genomic organization and chromosomal localization. Gene. 1998 Aug 17;216(1):31-8. 9714720
  3. Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S: Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. DNA Res. 1994;1(5):223-9. 7584044
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