T3DB: Utrophin

You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on Toxin, Toxin Target Database.

Name	Utrophin
Synonyms	DMDL DRP-1 DRP1 Dystrophin-related protein 1
Gene Name	UTRN
Organism	Human
Amino acid sequence	>lcl\|BSEQ0009864\|Utrophin MAKYGEHEASPDNGQNEFSDIIKSRSDEHNDVQKKTFTKWINARFSKSGKPPINDMFTDL KDGRKLLDLLEGLTGTSLPKERGSTRVHALNNVNRVLQVLHQNNVELVNIGGTDIVDGNH KLTLGLLWSIILHWQVKDVMKDVMSDLQQTNSEKILLSWVRQTTRPYSQVNVLNFTTSWT DGLAFNAVLHRHKPDLFSWDKVVKMSPIERLEHAFSKAQTYLGIEKLLDPEDVAVQLPDK KSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEAINIQSTAPEEEHESPRAET PSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELT AHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLM ELQKKQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSL THMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCL LKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVGQL LDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVRE QAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMK MQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEW KNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLPSLKDS CQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQEAVEDRQQHL ENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKKTLDEILENQ KPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLEEIALTLRA FEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIE TNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEW MTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVKILKDNIKLLAAKVPSGG QELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELLHYLDLETTWLNTLEERMKSTE VLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAFNSRYED LSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKI QAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANF EQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTGR HIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSEWL SATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAALQNLIEGSEP ILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEK KPTSKQEEIVKRLVSELDDANLQVENVRDQALILMNARGSSSRELVEPKLAELNRNFEKV SQHIKSAKLLIAQEPLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDE KMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKMGQLA SGIRSSLLPTDYLVEINKILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLDKL GEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQ FHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGD GIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWL TKAEHAMQKRSTTELGENLQELRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPERDKI SESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSH RTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRH PQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQ WDDHREETEELMRKYEARLYILQQARRDPLTKQISDNQILLQELGPGDGIVMAFDNVLQK LLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQ EAETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKAL GNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDE ELKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRR NLQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAM DDLDADMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLS PLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGPSSQHFLSTSVQLPWQR SISHNKVPYYINHQTQTTCWDHPKMTELFQSLADLNNVRFSAYRTAIKIRRLQKALCLDL LELSTTNEIFKQHKLNQNDQLLSVPDVINCLTTTYDGLEQMHKDLVNVPLCVDMCLNWLL NVYDTGRTGKIRVQSLKIGLMSLSKGLLEEKYRYLFKEVAGPTEMCDQRQLGLLLHDAIQ IPRQLGEVAAFGGSNIEPSVRSCFQQNNNKPEISVKEFIDWMHLEPQSMVWLPVLHRVAA AETAKHQAKCNICKECPIVGFRYRSLKHFNYDVCQSCFFSGRTAKGHKLHYPMVEYCIPT TSGEDVRDFTKVLKNKFRSKKYFAKHPRLGYLPVQTVLEGDNLETPITLISMWPEHYDPS QSPQLFHDDTHSRIEQYATRLAQMERTNGSFLTDSSSTTGSVEDEHALIQQYCQTLGGES PVSQPQSPAQILKSVEREERGELERIIADLEEEQRNLQVEYEQLKDQHLRRGLPVGSPPE SIISPHHTSEDSELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPESDS RINGVSPWASPQHSALSYSLDPDASGPQFHQAAGEDLLAPPHDTSTDLTEVMEQIHSTFP SCCPNVPSRPQAM
Number of residues	3433
Molecular Weight	394463.09
Theoretical pI	Not Available
GO Classification	Functions integrin binding vinculin binding actin binding protein kinase binding zinc ion binding Processes positive regulation of cell-matrix adhesion regulation of sodium ion transmembrane transporter activity muscle contraction muscle organ development Components membrane protein complex filopodium membrane cytoskeleton postsynaptic membrane dystrophin-associated glycoprotein complex plasma membrane cell junction extracellular exosome nucleoplasm sarcolemma filopodium neuromuscular junction cytoplasm
General Function	Zinc ion binding
Specific Function	May play a role in anchoring the cytoskeleton to the plasma membrane.
Pfam Domain Function	ZZ (PF00569 ) CH (PF00307 ) Spectrin (PF00435 ) EF-hand_2 (PF09068 ) EF-hand_3 (PF09069 )
Transmembrane Regions	Not Available
GenBank Protein ID	Not Available
UniProtKB ID	P46939
UniProtKB Entry Name	UTRO_HUMAN
Cellular Location	Cell junction
Gene sequence	>lcl\|BSEQ0021963\|Utrophin (UTRN) ATGGCCAAGTATGGAGAACATGAAGCCAGTCCTGACAATGGGCAGAACGAATTCAGTGAT ATCATTAAGTCCAGATCTGATGAACACAATGACGTACAGAAGAAAACCTTTACCAAATGG ATAAATGCTCGATTTTCAAAGAGTGGGAAACCACCCATCAATGATATGTTCACAGACCTC AAAGATGGAAGGAAGCTATTGGATCTTCTAGAAGGCCTCACAGGAACATCACTGCCAAAG GAACGTGGTTCCACAAGGGTACATGCCTTAAATAACGTCAACAGAGTGCTGCAGGTTTTA CATCAGAACAATGTGGAATTAGTGAATATAGGGGGAACTGACATTGTGGATGGAAATCAC AAACTGACTTTGGGGTTACTTTGGAGCATCATTTTGCACTGGCAGGTGAAAGATGTCATG AAGGATGTCATGTCGGACCTGCAGCAGACGAACAGTGAGAAGATCCTGCTCAGCTGGGTG CGTCAGACCACCAGGCCCTACAGCCAAGTCAACGTCCTCAACTTCACCACCAGCTGGACA GATGGACTCGCCTTTAATGCTGTCCTCCACCGACATAAACCTGATCTCTTCAGCTGGGAT AAAGTTGTCAAAATGTCACCAATTGAGAGACTTGAACATGCCTTCAGCAAGGCTCAAACT TATTTGGGAATTGAAAAGCTGTTAGATCCTGAAGATGTTGCCGTTCAGCTTCCTGACAAG AAATCCATAATTATGTATTTAACATCTTTGTTTGAGGTGCTACCTCAGCAAGTCACCATA GACGCCATCCGTGAGGTAGAGACACTCCCAAGGAAATATAAAAAAGAATGTGAAGAAGAG GCAATTAATATACAGAGTACAGCGCCTGAGGAGGAGCATGAGAGTCCCCGAGCTGAAACT CCCAGCACTGTCACTGAGGTTGACATGGATCTGGACAGCTATCAGATTGCGTTGGAGGAA GTGCTGACCTGGTTGCTTTCTGCTGAGGACACTTTCCAGGAGCAGGATGATATTTCTGAT GATGTTGAAGAAGTCAAAGACCAGTTTGCAACCCATGAAGCTTTTATGATGGAACTGACT GCACACCAGAGCAGTGTGGGCAGCGTCCTGCAGGCAGGCAACCAACTGATAACACAAGGA ACTCTGTCAGACGAAGAAGAATTTGAGATTCAGGAACAGATGACCCTGCTGAATGCTAGA TGGGAGGCTCTTAGGGTGGAGAGTATGGACAGACAGTCCCGGCTGCACGATGTGCTGATG GAACTGCAGAAGAAGCAACTGCAGCAGCTCTCCGCCTGGTTAACACTCACAGAGGAGCGC ATTCAGAAGATGGAAACTTGCCCCCTGGATGATGATGTAAAATCTCTACAAAAGCTGCTA GAAGAACATAAAAGTTTGCAAAGTGATCTTGAGGCTGAACAGGTGAAAGTAAATTCACTA ACTCACATGGTGGTCATTGTTGATGAAAACAGTGGTGAGAGTGCTACAGCTATCCTAGAA GACCAGTTACAGAAACTTGGTGAGCGCTGGACAGCAGTATGCCGTTGGACTGAAGAACGC TGGAATAGGTTACAAGAAATCAATATATTGTGGCAGGAATTATTGGAAGAACAGTGCTTG TTGAAAGCTTGGTTAACCGAAAAAGAAGAGGCTTTAAATAAAGTCCAGACAAGCAACTTC AAAGACCAAAAGGAACTAAGTGTCAGTGTTCGACGTCTGGCTATTTTGAAGGAAGACATG GAAATGAAGCGTCAAACATTGGATCAGCTGAGTGAGATTGGCCAGGATGTGGGACAATTA CTTGATAATTCCAAGGCATCTAAGAAGATCAACAGTGACTCAGAGGAACTGACTCAAAGA TGGGATTCTTTGGTTCAGAGACTAGAAGATTCCTCCAACCAGGTGACTCAGGCTGTAGCA AAGCTGGGGATGTCTCAGATTCCTCAGAAGGACCTTTTGGAGACTGTTCGTGTAAGAGAA CAAGCAATTACAAAAAAATCTAAGCAGGAACTGCCTCCTCCTCCTCCCCCAAAGAAGAGA CAGATCCATGTGGATATTGAAGCTAAGAAAAAGTTTGATGCTATAAGTGCAGAGCTGTTG AACTGGATTTTGAAATGGAAAACTGCCATTCAGACCACAGAGATAAAAGAGTATATGAAG ATGCAAGACACTTCCGAAATGAAAAAGAAGTTGAAGGCATTAGAAAAAGAACAGAGAGAA AGAATCCCCAGAGCAGATGAATTAAACCAAACTGGACAAATCCTTGTGGAGCAAATGGGA AAAGAAGGCCTTCCTACTGAAGAAATAAAAAATGTTCTGGAGAAGGTTTCATCAGAATGG AAGAATGTATCTCAACATTTGGAAGATCTAGAAAGAAAGATTCAGCTACAGGAAGATATA AATGCTTATTTCAAGCAGCTTGATGAGCTTGAAAAGGTCATCAAGACAAAGGAGGAGTGG GTAAAACACACTTCCATTTCTGAATCTTCCCGGCAGTCCTTGCCAAGCTTGAAGGATTCC TGTCAGCGGGAATTGACAAATCTTCTTGGCCTTCACCCCAAAATTGAAATGGCTCGTGCA AGCTGCTCGGCCCTGATGTCTCAGCCTTCTGCCCCAGATTTTGTCCAGCGGGGCTTCGAT AGCTTTCTGGGCCGCTACCAAGCTGTACAAGAGGCTGTAGAGGATCGTCAACAACATCTA GAGAATGAACTGAAGGGCCAACCTGGACATGCATATCTGGAAACATTGAAAACACTGAAA GATGTGCTAAATGATTCAGAAAATAAGGCCCAGGTGTCTCTGAATGTCCTTAATGATCTT GCCAAGGTGGAGAAGGCCCTGCAAGAAAAAAAGACCCTTGATGAAATCCTTGAGAATCAG AAACCTGCATTACATAAACTTGCAGAAGAAACAAAGGCTCTGGAGAAAAATGTTCATCCT GATGTAGAAAAATTATATAAGCAAGAATTTGATGATGTGCAAGGAAAGTGGAACAAGCTA AAGGTCTTGGTTTCCAAAGATCTACATTTGCTTGAGGAAATTGCTCTCACACTCAGAGCT TTTGAGGCCGATTCAACAGTCATTGAGAAGTGGATGGATGGCGTGAAAGACTTCTTAATG AAACAGCAGGCTGCCCAAGGAGACGACGCAGGTCTACAGAGGCAGTTAGACCAGTGCTCT GCATTTGTTAATGAAATAGAAACAATTGAATCATCTCTGAAAAACATGAAGGAAATAGAG ACTAATCTTCGAAGTGGTCCAGTTGCTGGAATAAAAACTTGGGTGCAGACAAGACTAGGT GACTACCAAACTCAACTGGAGAAACTTAGCAAGGAGATCGCTACTCAAAAAAGTAGGTTG TCTGAAAGTCAAGAAAAAGCTGCGAACCTGAAGAAAGACTTGGCAGAGATGCAGGAATGG ATGACCCAGGCCGAGGAAGAATATTTGGAGCGGGATTTTGAGTACAAGTCACCAGAAGAG CTTGAGAGTGCTGTGGAAGAGATGAAGAGGGCAAAAGAGGATGTGTTGCAGAAGGAGGTG AGAGTGAAGATTCTCAAGGACAACATCAAGTTATTAGCTGCCAAGGTGCCCTCTGGTGGC CAGGAGTTGACGTCTGAGCTGAATGTTGTGCTGGAGAATTACCAACTTCTTTGTAATAGA ATTCGAGGAAAGTGCCACACGCTAGAGGAGGTCTGGTCTTGTTGGATTGAACTGCTTCAC TATTTGGATCTTGAAACTACCTGGTTAAACACTTTGGAAGAGCGGATGAAGAGCACAGAG GTCCTGCCTGAGAAGACGGATGCTGTCAACGAAGCCCTGGAGTCTCTGGAATCTGTTCTG CGCCACCCGGCAGATAATCGCACCCAGATTCGAGAGCTTGGCCAGACTCTGATTGATGGG GGGATCCTGGATGATATAATCAGTGAGAAACTGGAGGCTTTCAACAGCCGATATGAAGAT CTAAGTCACCTGGCAGAGAGCAAGCAGATTTCTTTGGAAAAGCAACTCCAGGTGCTGCGG GAAACTGACCAGATGCTTCAAGTCTTGCAAGAGAGCTTGGGGGAGCTGGACAAACAGCTC ACCACATACCTGACTGACAGGATAGATGCTTTCCAAGTTCCACAGGAAGCTCAGAAAATC CAAGCAGAGATCTCAGCCCATGAGCTAACCCTAGAGGAGTTGAGAAGAAATATGCGTTCT CAGCCCCTGACCTCCCCAGAGAGTAGGACTGCCAGAGGAGGAAGTCAGATGGATGTGCTA CAGAGGAAACTCCGAGAGGTGTCCACAAAGTTCCAGCTTTTCCAGAAGCCAGCTAACTTC GAGCAGCGCATGCTGGACTGCAAGCGTGTGCTGGATGGCGTGAAAGCAGAACTTCACGTT CTGGATGTGAAGGACGTAGACCCTGACGTCATACAGACGCACCTGGACAAGTGTATGAAA CTGTATAAAACTTTGAGTGAAGTCAAACTTGAAGTGGAAACTGTGATTAAAACAGGAAGA CATATTGTCCAGAAACAGCAAACGGACAACCCAAAAGGGATGGATGAGCAGCTGACTTCC CTGAAGGTTCTTTACAATGACCTGGGCGCACAGGTGACAGAAGGAAAACAGGATCTGGAA AGAGCATCACAGTTGGCCCGGAAAATGAAGAAAGAGGCTGCTTCTCTCTCTGAATGGCTT TCTGCTACTGAAACTGAATTGGTACAGAAGTCCACTTCAGAAGGTCTGCTTGGTGACTTG GATACAGAAATTTCCTGGGCTAAAAATGTTCTGAAGGATCTGGAAAAGAGAAAAGCTGAT TTAAATACCATCACAGAGAGTAGTGCTGCCCTGCAAAACTTGATTGAGGGCAGTGAGCCT ATTTTAGAAGAGAGGCTCTGCGTCCTTAACGCTGGGTGGAGCCGAGTTCGTACCTGGACT GAAGATTGGTGCAATACCTTGATGAACCATCAGAACCAGCTAGAAATATTTGATGGGAAC GTGGCTCACATAAGTACCTGGCTTTATCAAGCTGAAGCTCTATTGGATGAAATTGAAAAG AAACCAACAAGTAAACAGGAAGAAATTGTGAAGCGTTTAGTATCTGAGCTGGATGATGCC AACCTCCAGGTTGAAAATGTCCGCGATCAAGCCCTTATTTTGATGAATGCCCGTGGAAGC TCAAGCAGGGAGCTTGTAGAACCAAAGTTAGCTGAGCTGAATAGGAACTTTGAAAAGGTG TCTCAACATATCAAAAGTGCCAAATTGCTAATTGCTCAGGAACCATTATACCAATGTTTG GTCACCACTGAAACATTTGAAACTGGTGTGCCTTTCTCTGACTTGGAAAAATTAGAAAAT GACATAGAAAATATGTTAAAATTTGTGGAAAAACACTTGGAATCCAGTGATGAAGATGAA AAGATGGATGAGGAGAGTGCCCAGATTGAGGAAGTTCTACAAAGAGGAGAAGAAATGTTA CATCAACCTATGGAAGATAATAAAAAAGAAAAGATCCGTTTGCAATTATTACTTTTGCAT ACTAGATACAACAAAATTAAGGCAATCCCTATTCAACAGAGGAAAATGGGTCAACTTGCT TCTGGAATTAGATCATCACTTCTTCCTACAGATTATCTGGTTGAAATTAACAAAATTTTA CTTTGCATGGATGATGTTGAATTATCGCTTAATGTTCCAGAGCTCAACACTGCTATTTAC GAAGACTTCTCTTTTCAGGAAGACTCTCTGAAGAATATCAAAGACCAACTGGACAAACTT GGAGAGCAGATTGCAGTCATTCATGAAAAACAGCCAGATGTCATCCTTGAAGCCTCTGGA CCTGAAGCCATTCAGATCAGAGATACACTTACTCAGCTGAATGCAAAATGGGACAGAATT AATAGAATGTACAGTGATCGGAAAGGTTGTTTTGACAGGGCAATGGAAGAATGGAGACAG TTCCATTGTGACCTTAATGACCTCACACAGTGGATAACAGAGGCTGAAGAATTACTGGTT GATACCTGTGCTCCAGGTGGCAGCCTGGACTTAGAGAAAGCCAGGATACATCAGCAGGAA CTTGAGGTGGGCATCAGCAGCCACCAGCCCAGTTTTGCAGCACTAAACCGAACTGGGGAT GGGATTGTGCAGAAACTCTCCCAGGCAGATGGAAGCTTCTTGAAAGAAAAACTGGCAGGT TTAAACCAACGCTGGGATGCAATTGTTGCAGAAGTGAAGGATAGGCAGCCAAGGCTAAAA GGAGAAAGTAAGCAGGTGATGAAGTACAGGCATCAGCTAGATGAGATTATCTGTTGGTTA ACAAAGGCTGAGCATGCTATGCAAAAGAGATCAACCACCGAATTGGGAGAAAACCTGCAA GAATTAAGAGACTTAACTCAAGAAATGGAAGTACATGCTGAAAAACTCAAATGGCTGAAT AGAACTGAATTGGAGATGCTTTCAGATAAAAGTCTGAGTTTACCTGAAAGGGATAAAATT TCAGAAAGCTTAAGGACTGTAAATATGACATGGAATAAGATTTGCAGAGAGGTGCCTACC ACCCTGAAGGAATGCATCCAGGAGCCCAGTTCTGTTTCACAGACAAGGATTGCTGCTCAT CCTAATGTCCAAAAGGTGGTGCTAGTATCATCTGCGTCAGATATTCCTGTTCAGTCTCAT CGTACTTCGGAAATTTCAATTCCTGCTGATCTTGATAAAACTATAACAGAACTAGCCGAC TGGCTGGTATTAATCGACCAGATGCTGAAGTCCAACATTGTCACTGTTGGGGATGTAGAA GAGATCAATAAGACCGTTTCCCGAATGAAAATTACAAAGGCTGACTTAGAACAGCGCCAT CCTCAGCTGGATTATGTTTTTACATTGGCACAGAATTTGAAAAATAAAGCTTCCAGTTCA GATATGAGAACAGCAATTACAGAAAAATTGGAAAGGGTCAAGAACCAGTGGGATGGCACC CAGCATGGCGTTGAGCTAAGACAGCAGCAGCTTGAGGACATGATTATTGACAGTCTTCAG TGGGATGACCATAGGGAGGAGACTGAAGAACTGATGAGAAAATATGAGGCTCGACTCTAT ATTCTTCAGCAAGCCCGACGGGATCCACTCACCAAACAAATTTCTGATAACCAAATACTG CTTCAAGAACTGGGTCCTGGAGATGGTATCGTCATGGCGTTCGATAACGTCCTGCAGAAA CTCCTGGAGGAATATGGGAGTGATGACACAAGGAATGTGAAAGAAACCACAGAGTACTTA AAAACATCATGGATCAATCTCAAACAAAGTATTGCTGACAGACAGAACGCCTTGGAGGCT GAGTGGAGGACGGTGCAGGCCTCTCGCAGAGATCTGGAAAACTTCCTGAAGTGGATCCAA GAAGCAGAGACCACAGTGAATGTGCTTGTGGATGCCTCTCATCGGGAGAATGCTCTTCAG GATAGTATCTTGGCCAGGGAACTCAAACAGCAGATGCAGGACATCCAGGCAGAAATTGAT GCCCACAATGACATATTTAAAAGCATTGACGGAAACAGGCAGAAGATGGTAAAAGCTTTG GGAAATTCTGAAGAGGCTACTATGCTTCAACATCGACTGGATGATATGAACCAAAGATGG AATGACTTAAAAGCAAAATCTGCTAGCATCAGGGCCCATTTGGAGGCCAGCGCTGAGAAG TGGAACAGGTTGCTGATGTCCTTAGAAGAACTGATCAAATGGCTGAATATGAAAGATGAA GAGCTTAAGAAACAAATGCCTATTGGAGGAGATGTTCCAGCCTTACAGCTCCAGTATGAC CATTGTAAGGCCCTGAGACGGGAGTTAAAGGAGAAAGAATATTCTGTCCTGAATGCTGTC GACCAGGCCCGAGTTTTCTTGGCTGATCAGCCAATTGAGGCCCCTGAAGAGCCAAGAAGA AACCTACAATCAAAAACAGAATTAACTCCTGAGGAGAGAGCCCAAAAGATTGCCAAAGCC ATGCGCAAACAGTCTTCTGAAGTCAAAGAAAAATGGGAAAGTCTAAATGCTGTAACTAGC AATTGGCAAAAGCAAGTGGACAAGGCATTGGAGAAACTCAGAGACCTGCAGGGAGCTATG GATGACCTGGACGCTGACATGAAGGAGGCAGAGTCCGTGCGGAATGGCTGGAAGCCCGTG GGAGACTTACTCATTGACTCGCTGCAGGATCACATTGAAAAAATCATGGCATTTAGAGAA GAAATTGCACCAATCAACTTTAAAGTTAAAACGGTGAATGATTTATCCAGTCAGCTGTCT CCACTTGACCTGCATCCCTCTCTAAAGATGTCTCGCCAGCTAGATGACCTTAATATGCGA TGGAAACTTTTACAGGTTTCTGTGGATGATCGCCTTAAACAGCTTCAGGAAGCCCACAGA GATTTTGGACCATCCTCTCAGCATTTTCTCTCTACGTCAGTCCAGCTGCCGTGGCAAAGA TCCATTTCACATAATAAAGTGCCCTATTACATCAACCATCAAACACAGACCACCTGTTGG GACCATCCTAAAATGACCGAACTCTTTCAATCCCTTGCTGACCTGAATAATGTACGTTTT TCTGCCTACCGTACAGCAATCAAAATCCGAAGACTACAAAAAGCACTATGTTTGGATCTC TTAGAGTTGAGTACAACAAATGAAATTTTCAAACAGCACAAGTTGAACCAAAATGACCAG CTCCTCAGTGTTCCAGATGTCATCAACTGTCTGACAACAACTTATGATGGACTTGAGCAA ATGCATAAGGACCTGGTCAACGTTCCACTCTGTGTTGATATGTGTCTCAATTGGTTGCTC AATGTCTATGACACGGGTCGAACTGGAAAAATTAGAGTGCAGAGTCTGAAGATTGGATTA ATGTCTCTCTCCAAAGGTCTCTTGGAAGAAAAATACAGATATCTCTTTAAGGAAGTTGCA GGGCCAACAGAAATGTGTGACCAGAGGCAGCTGGGCCTGTTACTTCATGATGCCATCCAG ATCCCCCGGCAGCTAGGTGAAGTAGCAGCTTTTGGAGGCAGTAATATTGAGCCTAGTGTT CGCAGCTGCTTCCAACAGAATAACAATAAACCAGAAATAAGTGTGAAAGAGTTTATAGAT TGGATGCATTTGGAACCACAGTCCATGGTTTGGCTCCCAGTTTTACATCGAGTGGCAGCA GCGGAGACTGCAAAACATCAGGCCAAATGCAACATCTGTAAAGAATGTCCAATTGTCGGG TTCAGGTATAGAAGCCTTAAGCATTTTAACTATGATGTCTGCCAGAGTTGTTTCTTTTCG GGTCGAACAGCAAAAGGTCACAAATTACATTACCCAATGGTGGAATATTGTATACCTACA ACATCTGGGGAAGATGTACGAGACTTCACAAAGGTACTTAAGAACAAGTTCAGGTCGAAG AAGTACTTTGCCAAACACCCTCGACTTGGTTACCTGCCTGTCCAGACAGTTCTTGAAGGT GACAACTTAGAGACTCCTATCACACTCATCAGTATGTGGCCAGAGCACTATGACCCCTCA CAATCTCCTCAACTGTTTCATGATGACACCCATTCAAGAATAGAACAATATGCCACACGA CTGGCCCAGATGGAAAGGACTAATGGGTCTTTTCTCACTGATAGCAGCTCCACCACAGGA AGTGTGGAAGACGAGCACGCCCTCATCCAGCAGTATTGCCAAACACTCGGAGGAGAGTCC CCAGTGAGCCAGCCGCAGAGCCCAGCTCAGATCCTGAAGTCAGTAGAGAGGGAAGAACGT GGAGAACTGGAGAGGATCATTGCTGACCTGGAGGAAGAACAAAGAAATCTACAGGTGGAG TATGAGCAGCTGAAGGACCAGCACCTCCGAAGGGGGCTCCCTGTCGGTTCACCGCCAGAG TCGATTATATCTCCCCATCACACGTCTGAGGATTCAGAACTTATAGCAGAAGCAAAACTC CTCAGGCAGCACAAAGGTCGGCTGGAGGCTAGGATGCAGATTTTAGAAGATCACAATAAA CAGCTGGAGTCTCAGCTCCACCGCCTCCGACAGCTGCTGGAGCAGCCTGAATCTGATTCC CGAATCAATGGTGTTTCCCCATGGGCTTCTCCTCAGCATTCTGCACTGAGCTACTCGCTT GATCCAGATGCCTCCGGCCCACAGTTCCACCAGGCAGCGGGAGAGGACCTGCTGGCCCCA CCGCACGACACCAGCACGGATCTCACGGAGGTCATGGAGCAGATTCACAGCACGTTTCCA TCTTGCTGCCCAAATGTTCCCAGCAGGCCACAGGCAATGTGA
GenBank Gene ID	Not Available
GeneCard ID	Not Available
GenAtlas ID	Not Available
HGNC ID	HGNC:12635
Chromosome Location	6
Locus	Not Available
References	Tinsley JM, Blake DJ, Roche A, Fairbrother U, Riss J, Byth BC, Knight AE, Kendrick-Jones J, Suthers GK, Love DR, et al.: Primary structure of dystrophin-related protein. Nature. 1992 Dec 10;360(6404):591-3. 1461283 Wilson J, Putt W, Jimenez C, Edwards YH: Up71 and up140, two novel transcripts of utrophin that are homologues of short forms of dystrophin. Hum Mol Genet. 1999 Jul;8(7):1271-8. 10369873 Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S: The DNA sequence and analysis of human chromosome 6. Nature. 2003 Oct 23;425(6960):805-11. 14574404 Burton EA, Tinsley JM, Holzfeind PJ, Rodrigues NR, Davies KE: A second promoter provides an alternative target for therapeutic up-regulation of utrophin in Duchenne muscular dystrophy. Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):14025-30. 10570192 Ahn AH, Kunkel LM: Syntrophin binds to an alternatively spliced exon of dystrophin. J Cell Biol. 1995 Feb;128(3):363-71. 7844150 Ahn AH, Freener CA, Gussoni E, Yoshida M, Ozawa E, Kunkel LM: The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives. J Biol Chem. 1996 Feb 2;271(5):2724-30. 8576247 Tommasi di Vignano A, Di Zenzo G, Sudol M, Cesareni G, Dente L: Contribution of the different modules in the utrophin carboxy-terminal region to the formation and regulation of the DAP complex. FEBS Lett. 2000 Apr 14;471(2-3):229-34. 10767429 James M, Nuttall A, Ilsley JL, Ottersbach K, Tinsley JM, Sudol M, Winder SJ: Adhesion-dependent tyrosine phosphorylation of (beta)-dystroglycan regulates its interaction with utrophin. J Cell Sci. 2000 May;113 ( Pt 10):1717-26. 10769203 Bhosle RC, Michele DE, Campbell KP, Li Z, Robson RM: Interactions of intermediate filament protein synemin with dystrophin and utrophin. Biochem Biophys Res Commun. 2006 Aug 4;346(3):768-77. Epub 2006 Jun 9. 16777071 Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006 Nov 3;127(3):635-48. 17081983 Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. 18669648 Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. 19690332 Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal. 2010 Jan 12;3(104):ra3. doi: 10.1126/scisignal.2000475. 20068231 Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. 21269460 Singh SM, Bandi S, Winder SJ, Mallela KM: The actin binding affinity of the utrophin tandem calponin-homology domain is primarily determined by its N-terminal domain. Biochemistry. 2014 Mar 25;53(11):1801-9. doi: 10.1021/bi500149q. Epub 2014 Mar 14. 24628267 Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. 24275569 Vaca Jacome AS, Rabilloud T, Schaeffer-Reiss C, Rompais M, Ayoub D, Lane L, Bairoch A, Van Dorsselaer A, Carapito C: N-terminome analysis of the human mitochondrial proteome. Proteomics. 2015 Jul;15(14):2519-24. doi: 10.1002/pmic.201400617. Epub 2015 Jun 8. 25944712 Keep NH, Norwood FL, Moores CA, Winder SJ, Kendrick-Jones J: The 2.0 A structure of the second calponin homology domain from the actin-binding region of the dystrophin homologue utrophin. J Mol Biol. 1999 Jan 22;285(3):1257-64. 9887274 Keep NH, Winder SJ, Moores CA, Walke S, Norwood FL, Kendrick-Jones J: Crystal structure of the actin-binding region of utrophin reveals a head-to-tail dimer. Structure. 1999 Dec 15;7(12):1539-46. 10647184 Moores CA, Keep NH, Kendrick-Jones J: Structure of the utrophin actin-binding domain bound to F-actin reveals binding by an induced fit mechanism. J Mol Biol. 2000 Mar 24;297(2):465-80. 10715214