Iron-responsive element-binding protein 2

NameIron-responsive element-binding protein 2
Synonyms
  • IRE-BP 2
  • Iron regulatory protein 2
  • IRP2
Gene NameIREB2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0008975|Iron-responsive element-binding protein 2
MDAPKAGYAFEYLIETLNDSSHKKFFDVSKLGTKYDVLPYSIRVLLEAAVRNCDGFLMKK
EDVMNILDWKTKQSNVEVPFFPARVLLQDFTGIPAMVDFAAMREAVKTLGGDPEKVHPAC
PTDLTVDHSLQIDFSKCAIQNAPNPGGGDLQKAGKLSPVKVQPKKLPCRGQTTCRGSCDS
GELGRNSGTFSSQIENTPILCPFHLQPVPEPETVLKNQEVEFGRNRERLQFFKWSSRVFK
NVAVIPPGTGMAHQINLEYLSRVVFEEKDLLFPDSVVGTDSHITMVNGLGILGWGVGGIE
TEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSIDVVLGITKHLRQVGVAGKFVEFFGSGV
SQLSIVDRTTIANMCPEYGAILSFFPVDNVTLKHLEHTGFSKAKLESMETYLKAVKLFRN
DQNSSGEPEYSQVIQINLNSIVPSVSGPKRPQDRVAVTDMKSDFQACLNEKVGFKGFQIA
AEKQKDIVSIHYEGSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVEAGLRVKP
YIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFEIVGYGCSICVGNTAPLSDAVLNAVKQGD
LVTCGILSGNKNFEGRLCDCVRANYLASPPLVVAYAIAGTVNIDFQTEPLGTDPTGKNIY
LHDIWPSREEVHRVEEEHVILSMFKALKDKIEMGNKRWNSLEAPDSVLFPWDLKSTYIRC
PSFFDKLTKEPIALQAIENAHVLLYLGDSVTTDHISPAGSIARNSAAAKYLTNRGLTPRE
FNSYGARRGNDAVMTRGTFANIKLFNKFIGKPAPKTIHFPSGQTLDVFEAAELYQKEGIP
LIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLQFLPGENAD
SLGLSGRETFSLTFPEELSPGITLNIQTSTGKVFSVIASFEDDVEITLYKHGGLLNFVAR
KFS
Number of residues963
Molecular Weight105043.65
Theoretical pINot Available
GO Classification
Functions
  • RNA binding
  • metal ion binding
  • 4 iron, 4 sulfur cluster binding
  • iron-responsive element binding
  • translation repressor activity
Processes
  • iron ion transport
  • cellular iron ion homeostasis
  • metabolic process
Components
  • cytoplasm
General FunctionTranslation repressor activity
Specific FunctionRNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP48200
UniProtKB Entry NameIREB2_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0013541|Iron-responsive element-binding protein 2 (IREB2)
ATGGACGCCCCAAAAGCAGGATACGCCTTTGAGTACCTTATTGAAACATTAAATGACAGT
TCACATAAGAAGTTCTTCGATGTATCTAAACTTGGCACCAAGTATGATGTTCTGCCTTAC
TCAATACGGGTCTTGTTGGAAGCTGCTGTACGAAATTGTGATGGCTTTTTAATGAAGAAG
GAAGATGTTATGAACATTTTAGACTGGAAAACCAAACAAAGCAATGTTGAAGTGCCCTTT
TTCCCTGCCCGTGTTCTTCTTCAAGATTTTACTGGAATACCAGCAATGGTGGATTTTGCT
GCTATGAGGGAGGCAGTGAAAACTCTTGGAGGTGATCCTGAGAAAGTCCATCCTGCTTGT
CCGACAGATCTTACAGTTGACCATTCTTTACAAATTGACTTCAGTAAATGTGCAATACAG
AATGCACCAAATCCTGGAGGTGGTGACCTGCAGAAAGCAGGAAAGCTCTCTCCACTTAAA
GTGCAGCCTAAGAAGCTTCCCTGCAGAGGCCAGACTACCTGCCGAGGATCTTGTGATTCT
GGAGAACTAGGCCGAAACTCAGGAACATTTTCTTCGCAGATTGAGAATACACCCATCCTG
TGTCCTTTTCATTTGCAACCAGTGCCTGAACCTGAAACAGTGTTAAAAAATCAAGAAGTA
GAATTCGGCAGAAATCGAGAGAGGCTTCAGTTTTTTAAGTGGAGTTCAAGAGTTTTTAAG
AATGTGGCAGTGATCCCTCCTGGAACTGGAATGGCTCATCAAATAAACTTAGAATATTTG
TCAAGAGTGGTTTTTGAAGAAAAAGACCTCCTCTTCCCAGACAGTGTAGTCGGCACAGAT
TCACACATAACGATGGTGAATGGTTTAGGGATTCTGGGGTGGGGGGTTGGAGGCATTGAA
ACAGAAGCAGTTATGCTTGGTCTGCCAGTTTCTCTTACTTTACCAGAGGTGGTTGGATGT
GAGTTAACTGGGTCATCAAACCCTTTTGTTACATCCATAGATGTTGTTCTTGGTATTACA
AAGCACCTCAGGCAAGTAGGAGTGGCTGGAAAGTTTGTTGAGTTTTTTGGAAGTGGAGTT
TCACAATTATCTATAGTTGATCGAACTACAATAGCAAACATGTGTCCGGAATATGGTGCT
ATCCTCAGCTTTTTCCCTGTTGACAATGTGACATTAAAACATTTAGAACATACAGGTTTT
AGCAAAGCCAAACTCGAATCAATGGAAACATACCTTAAAGCTGTGAAATTGTTTCGAAAT
GACCAGAATTCTTCAGGAGAACCTGAATACTCCCAGGTGATCCAGATTAATCTGAATTCA
ATAGTTCCATCTGTTAGTGGTCCAAAAAGACCTCAGGATAGAGTTGCTGTGACAGATATG
AAAAGCGATTTCCAGGCTTGCTTAAATGAAAAGGTTGGATTTAAAGGCTTCCAAATTGCA
GCTGAAAAACAAAAGGATATTGTCTCCATTCATTATGAAGGAAGTGAATATAAGCTGTCT
CATGGATCAGTGGTCATTGCTGCAGTTATCAGTTGTACCAATAATTGCAATCCATCTGTC
ATGCTTGCTGCAGGTCTTTTGGCTAAAAAGGCTGTTGAAGCTGGTCTGCGTGTTAAACCT
TATATAAGAACAAGTTTATCTCCAGGCAGTGGGATGGTTACACATTACCTCAGTTCAAGT
GGAGTATTACCATATCTAAGTAAGCTTGGATTTGAAATCGTTGGCTATGGATGTTCAACT
TGTGTGGGAAATACAGCACCCTTATCAGACGCAGTTTTAAATGCAGTAAAACAGGGTGAT
TTGGTTACCTGTGGAATTTTATCTGGAAACAAAAATTTTGAAGGTCGTCTTTGTGATTGT
GTTCGTGCCAATTATCTTGCCTCTCCACCCTTAGTGGTAGCTTATGCCATAGCAGGCACA
GTGAATATAGATTTCCAGACAGAACCTTTAGGTACTGACCCCACCGGCAAGAACATTTAC
CTGCATGATATTTGGCCTAGTCGAGAAGAAGTTCATCGAGTAGAGGAAGAACATGTTATA
CTATCCATGTTTAAAGCATTAAAAGATAAAATAGAAATGGGGAATAAACGGTGGAATTCC
TTAGAAGCACCGGATTCAGTTTTGTTTCCATGGGACTTAAAGTCTACTTATATCAGATGC
CCTTCATTTTTTGATAAACTTACCAAAGAGCCAATTGCACTCCAGGCTATTGAAAATGCC
CATGTCTTATTATATTTGGGAGACTCTGTCACAACAGATCATATATCACCTGCAGGAAGT
ATCGCTAGGAATAGTGCTGCCGCTAAGTATTTGACAAACAGAGGCCTTACCCCTCGTGAA
TTCAACTCTTACGGAGCTCGAAGAGGTAATGATGCTGTAATGACAAGAGGCACTTTTGCA
AATATCAAGCTTTTTAATAAGTTTATTGGAAAACCAGCTCCTAAAACAATTCATTTTCCA
TCAGGACAGACGCTAGATGTATTTGAGGCTGCAGAGCTGTACCAGAAAGAAGGTATCCCA
CTGATTATTTTAGCAGGAAAGAAATATGGTTCAGGAAACTCCAGAGACTGGGCTGCCAAA
GGACCGTATTTACTGGGTGTGAAAGCTGTTTTGGCCGAAAGTTATGAAAAAATACACAAA
GATCATTTGATTGGAATTGGCATAGCTCCACTTCAGTTCCTTCCAGGAGAAAATGCAGAT
TCCTTGGGCCTCTCCGGTAGAGAAACATTTTCTTTAACATTTCCTGAAGAACTGTCTCCT
GGAATTACATTGAATATACAGACAAGCACTGGAAAAGTATTCAGCGTGATTGCTTCGTTT
GAAGATGATGTGGAAATAACATTATACAAACATGGAGGATTATTAAACTTTGTGGCACGA
AAATTCTCATAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:6115
Chromosome Location15
LocusNot Available
References
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