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Excitatory amino acid transporter 4

NameExcitatory amino acid transporter 4
Synonyms
  • EAAT4
  • Sodium-dependent glutamate/aspartate transporter
  • Solute carrier family 1 member 6
Gene NameSLC1A6
OrganismHuman
Amino acid sequence
>lcl|BSEQ0004456|Excitatory amino acid transporter 4
MSSHGNSLFLRESGQRLGRVGWLQRLQESLQQRALRTRLRLQTMTLEHVLRFLRRNAFIL
LTVSAVVIGVSLAFALRPYQLTYRQIKYFSFPGELLMRMLQMLVLPLIVSSLVTGMASLD
NKATGRMGMRAAVYYMVTTIIAVFIGILMVTIIHPGKGSKEGLHREGRIETIPTADAFMD
LIRNMFPPNLVEACFKQFKTQYSTRVVTRTMVRTENGSEPGASMPPPFSVENGTSFLENV
TRALGTLQEMLSFEETVPVPGSANGINALGLVVFSVAFGLVIGGMKHKGRVLRDFFDSLN
EAIMRLVGIIIWYAPVGILFLIAGKILEMEDMAVLGGQLGMYTLTVIVGLFLHAGIVLPL
IYFLVTHRNPFPFIGGMLQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGA
TVNMDGTALYEALAAIFIAQVNNYELNLGQITTISITATAASVGAAGIPQAGLVTMVIVL
TSVGLPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVIEHLSQRELELQEAELTLPSLG
KPYKSLMAQEKGASRGRGGNESAM
Number of residues564
Molecular Weight61564.875
Theoretical pI9.54
GO Classification
Functions
  • sodium
  • L-aspartate transmembrane transporter activity
  • L-glutamate transmembrane transporter activity
Processes
  • transmembrane transport
  • regulation of membrane potential
  • aspartate transport
  • L-aspartate transmembrane transport
  • L-glutamate transport
  • ion transport
  • synaptic transmission
  • glutamate secretion
  • neurotransmitter secretion
Components
  • integral component of plasma membrane
  • membrane
  • plasma membrane
  • Golgi apparatus
General FunctionSodium:dicarboxylate symporter activity
Specific FunctionTransports L-glutamate and also L- and D-aspartate. Seems to act as a symport by cotransporting sodium.
Pfam Domain Function
Transmembrane Regions56-76 99-119 133-153 265-285 306-326 345-365 370-390 418-438 460-480 481-501
GenBank Protein ID930337
UniProtKB IDP48664
UniProtKB Entry NameEAA4_HUMAN
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0011633|Excitatory amino acid transporter 4 (SLC1A6)
ATGAGCAGCCATGGCAACAGCCTGTTCCTGCGGGAGAGCGGCCAGCGGCTGGGCCGGGTG
GGCTGGCTGCAGCGGCTGCAGGAAAGCCTGCAGCAGAGAGCACTGCGCACGCGCCTGCGC
CTGCAGACCATGACCCTCGAGCACGTGCTGCGCTTCCTGCGCCGAAACGCCTTCATTCTG
CTGACGGTCAGCGCCGTGGTCATTGGGGTCAGCCTGGCCTTTGCCCTGCGCCCATATCAG
CTCACCTACCGCCAGATCAAGTACTTCTCTTTTCCTGGAGAGCTTCTGATGAGGATGCTG
CAGATGCTGGTGTTACCTCTCATTGTCTCCAGCCTGGTCACAGGTATGGCATCCCTGGAC
AACAAGGCCACGGGGCGGATGGGGATGCGGGCAGCTGTGTACTACATGGTGACCACCATC
ATCGCGGTCTTCATCGGCATCCTCATGGTCACCATCATCCATCCCGGGAAGGGCTCCAAG
GAGGGGCTGCACCGGGAGGGCCGGATCGAGACCATCCCCACAGCTGATGCCTTCATGGAC
CTGATCAGAAATATGTTTCCACCAAACCTTGTGGAGGCCTGCTTCAAACAGTTCAAGACG
CAGTACAGCACGAGGGTGGTAACCAGGACCATGGTGAGGACAGAGAACGGGTCTGAGCCG
GGTGCCTCCATGCCTCCTCCATTCTCAGTGGAGAACGGAACCAGCTTCCTGGAAAATGTC
ACTCGGGCCTTGGGTACCCTGCAGGAGATGCTGAGCTTTGAGGAGACTGTACCCGTGCCT
GGCTCCGCCAATGGCATCAACGCCCTGGGCCTCGTGGTCTTCTCTGTGGCCTTTGGGCTG
GTCATTGGTGGCATGAAACACAAGGGCAGAGTCCTCAGGGACTTCTTCGACAGCCTCAAT
GAGGCTATTATGAGGCTGGTGGGCATCATTATCTGGTGA
GenBank Gene IDU18244
GeneCard IDNot Available
GenAtlas IDSLC1A6
HGNC IDHGNC:10944
Chromosome Location19
Locus19p13.12
References
  1. Fairman WA, Vandenberg RJ, Arriza JL, Kavanaugh MP, Amara SG: An excitatory amino-acid transporter with properties of a ligand-gated chloride channel. Nature. 1995 Jun 15;375(6532):599-603. 7791878
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