You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on Toxin, Toxin Target Database.
NameAlpha-mannosidase 2x
Synonyms
  • 3.2.1.114
  • Alpha-mannosidase IIx
  • Man IIx
  • MANA2X
  • Mannosidase alpha class 2A member 2
  • Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
Gene NameMAN2A2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009085|Alpha-mannosidase 2x
MKLKKQVTVCGAAIFCVAVFSLYLMLDRVQHDPTRHQNGGNFPRSQISVLQNRIEQLEQL
LEENHEIISHIKDSVLELTANAEGPPAMLPYYTVNGSWVVPPEPRPSFFSISPQDCQFAL
GGRGQKPELQMLTVSEELPFDNVDGGVWRQGFDISYDPHDWDAEDLQVFVVPHSHNDPGW
IKTFDKYYTEQTQHILNSMVSKLQEDPRRRFLWAEVSFFAKWWDNINVQKRAAVRRLVGN
GQLEIATGGWVMPDEANSHYFALIDQLIEGHQWLERNLGATPRSGWAVDPFGYSSTMPYL
LRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQTWDSDSSTDIFCHMMPFYSYDVPHTC
GPDPKICCQFDFKRLPGGRINCPWKVPPRAITEANVAERAALLLDQYRKKSQLFRSNVLL
VPLGDDFRYDKPQEWDAQFFNYQRLFDFFNSRPNLHVQAQFGTLSDYFDALYKRTGVEPG
ARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLEAHLRGAEVLYSLAAAHAR
RSGLAGRYPLSDFTLLTEARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRSLVNLKQVII
HAAHYLVLGDKETYHFDPEAPFLQVDDTRLSHDALPERTVIQLDSSPRFVVLFNPLEQER
FSMVSLLVNSPRVRVLSEEGQPLAVQISAHWSSATEAVPDVYQVSVPVRLPALGLGVLQL
QLGLDGHRTLPSSVRIYLHGRQLSVSRHEAFPLRVIDSGTSDFALSNRYMQVWFSGLTGL
LKSIRRVDEEHEQQVDMQVLVYGTRTSKDKSGAYLFLPDGEAKPYVPKEPPVLRVTEGPF
FSEVVAYYEHIHQAVRLYNLPGVEGLSLDISSLVDIRDYVNKELALHIHTDIDSQGIFFT
DLNGFQVQPRRYLKKLPLQANFYPMPVMAYIQDAQKRLTLHTAQALGVSSLKDGQLEVIL
DRRLMQDDNRGLGQGLKDNKRTCNRFRLLLERRTVGSEVQDSHSTSYPSLLSHLTSMYLN
APALALPVARMQLPGPGLRSFHPLASSLPCDFHLLNLRTLQAEEDTLPSAETALILHRKG
FDCGLEAKNLGFNCTTSQGKVALGSLFHGLDVVFLQPTSLTLLYPLASPSNSTDVYLEPM
EIATFRLRLG
Number of residues1150
Molecular Weight130537.495
Theoretical pINot Available
GO Classification
Functions
  • alpha-mannosidase activity
  • mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity
  • zinc ion binding
  • carbohydrate binding
  • hydrolase activity, hydrolyzing N-glycosyl compounds
Processes
  • cellular protein metabolic process
  • post-translational protein modification
  • protein N-linked glycosylation via asparagine
  • protein deglycosylation
  • mannose metabolic process
  • N-glycan processing
Components
  • integral component of membrane
  • Golgi membrane
General FunctionZinc ion binding
Specific FunctionCatalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.
Pfam Domain Function
Transmembrane Regions6-26
GenBank Protein IDNot Available
UniProtKB IDP49641
UniProtKB Entry NameMA2A2_HUMAN
Cellular LocationGolgi apparatus membrane
Gene sequence
>lcl|BSEQ0013604|Alpha-mannosidase 2x (MAN2A2)
ATGAAGCTGAAAAAGCAGGTGACAGTGTGTGGGGCTGCCATCTTCTGTGTGGCAGTCTTC
TCGCTCTACCTCATGCTGGACCGAGTGCAACACGATCCCACCCGACACCAGAATGGTGGG
AACTTCCCCCGGAGCCAAATTTCTGTGCTGCAGAACCGCATTGAGCAGCTGGAGCAGCTT
TTGGAGGAGAACCATGAGATTATCAGCCATATCAAGGACTCCGTGCTGGAGCTGACAGCC
AACGCAGAGGGCCCGCCCGCCATGCTGCCCTACTACACGGTCAATGGCTCCTGGGTGGTG
CCACCGGAGCCCCGGCCCAGCTTCTTCTCCATCTCCCCGCAGGACTGCCAGTTTGCTTTG
GGGGGCCGGGGTCAGAAGCCAGAGCTGCAGATGCTCACTGTGTCGGAGGAGCTGCCGTTT
GACAACGTGGATGGTGGTGTGTGGAGGCAAGGCTTCGACATCTCCTACGACCCGCACGAC
TGGGATGCTGAAGACCTGCAGGTGTTTGTGGTGCCCCACTCTCACAATGACCCAGGCTGG
ATCAAGACCTTTGACAAGTACTACACAGAGCAGACCCAACACATCCTCAATAGCATGGTG
TCTAAGCTGCAGGAGGACCCCCGGCGGCGCTTCCTCTGGGCAGAGGTCTCCTTCTTCGCC
AAGTGGTGGGACAACATCAATGTCCAAAAGAGAGCGGCAGTCCGAAGGCTGGTGGGAAAC
GGGCAGCTGGAGATTGCGACAGGAGGCTGGGTGATGCCAGATGAGGCCAATTCCCACTAC
TTTGCATTGATTGACCAGCTCATCGAAGGACACCAGTGGCTGGAGAGAAATCTTGGTGCA
ACCCCCCGCTCTGGCTGGGCAGTGGACCCCTTTGGATACAGCTCCACCATGCCTTACCTG
CTGCGCCGTGCCAACCTCACCAGCATGCTGATTCAGAGAGTGCACTATGCCATCAAGAAG
CACTTTGCTGCCACCCACAGCCTAGAGTTCATGTGGAGGCAGACATGGGACTCGGACTCC
AGCACAGACATCTTCTGTCACATGATGCCCTTCTACAGCTATGACGTCCCCCATACCTGT
GGCCCAGATCCCAAGATCTGCTGCCAATTTGATTTCAAACGCCTGCCTGGTGGGCGCATC
AACTGCCCTTGGAAGGTGCCACCCCGGGCCATCACAGAGGCCAACGTGGCAGAGAGGGCA
GCCCTGCTTCTGGACCAATACCGGAAGAAGTCCCAGCTGTTCCGAAGCAACGTCCTCCTG
GTGCCTCTTGGAGATGACTTCCGATATGACAAGCCCCAGGAGTGGGATGCCCAGTTCTTC
AACTACCAACGGCTCTTTGACTTCTTCAACAGCAGGCCTAACCTCCATGTGCAGGCCCAG
TTTGGCACTCTTTCTGACTATTTTGATGCCCTGTACAAGAGGACAGGGGTGGAGCCAGGG
GCCCGGCCTCCAGGGTTTCCTGTGCTGAGCGGGGATTTCTTCTCCTATGCGGACCGGGAG
GATCATTACTGGACAGGCTATTACACTTCCCGGCCCTTCTACAAGAGCTTAGACCGAGTC
CTGGAAGCCCACCTGCGGGGGGCAGAGGTTCTGTACAGCCTGGCTGCAGCTCACGCTCGC
CGCTCTGGTCTGGCTGGCCGGTACCCACTGTCTGATTTCACCCTCCTGACGGAAGCTCGG
CGCACATTGGGGCTCTTCCAGCATCACGATGCCATCACTGGCACGGCCAAGGAGGCTGTG
GTGGTGGACTATGGGGTCAGGCTTCTGCGCTCCCTTGTCAACCTGAAGCAGGTCATCATT
CATGCAGCCCACTATCTGGTGCTGGGGGACAAGGAGACCTACCACTTTGACCCTGAGGCG
CCCTTCCTCCAAGTGGATGACACTCGCTTAAGTCACGACGCCCTCCCAGAGCGCACGGTG
ATCCAGCTGGATTCCTCGCCCAGGTTTGTGGTCCTATTCAACCCACTGGAACAGGAGCGA
TTCAGCATGGTGTCCCTGCTGGTCAACTCTCCCCGCGTGCGTGTCCTTTCGGAGGAGGGT
CAGCCCCTGGCCGTGCAGATCAGCGCACACTGGAGCTCTGCCACCGAGGCGGTCCCTGAC
GTCTACCAGGTGTCTGTGCCTGTCCGCCTGCCAGCCCTGGGCCTGGGCGTGCTGCAGCTA
CAGCTGGGCCTGGATGGGCACCGCACGCTGCCCTCCTCTGTGCGCATCTACCTGCACGGC
CGGCAGCTGTCCGTCAGCAGGCACGAAGCGTTTCCTCTCCGTGTCATTGACTCTGGCACC
AGCGACTTCGCCCTCAGCAACCGCTACATGCAGGTCTGGTTCTCAGGCCTTACTGGGCTC
CTCAAGAGCATCCGAAGGGTGGATGAGGAGCACGAGCAGCAGGTGGACATGCAGGTCCTT
GTCTATGGCACCCGTACGTCCAAAGACAAGAGTGGAGCCTACCTCTTCCTGCCCGATGGC
GAGGCCAAGCCCTACGTCCCCAAGGAGCCCCCCGTGCTGCGTGTCACTGAAGGCCCTTTC
TTCTCAGAGGTGGTTGCGTACTATGAGCACATTCACCAGGCGGTCCGGCTTTACAATCTG
CCAGGGGTGGAGGGGCTGTCTCTGGACATATCATCCCTGGTGGACATCCGGGACTACGTC
AACAAGGAGCTGGCCCTGCACATCCATACAGACATCGACAGCCAGGGTATCTTCTTCACA
GACCTCAATGGCTTTCAGGTGCAGCCCCGACGGTATCTGAAGAAGCTCCCCCTCCAGGCC
AACTTCTACCCCATGCCAGTCATGGCCTATATCCAGGACGCACAGAAGCGCCTCACGCTG
CACACTGCCCAGGCCCTGGGTGTCTCTAGCCTCAAAGATGGCCAGCTGGAGGTGATCTTG
GACCGGCGGCTGATGCAGGATGACAACCGGGGCCTAGGCCAAGGGCTCAAGGACAACAAG
AGAACCTGCAACCGTTTCCGCCTCCTGCTAGAGCGGCGAACCGTGGGCAGTGAGGTCCAA
GATAGCCACTCTACCAGCTACCCATCCCTCCTCAGCCACCTGACCTCCATGTACCTGAAC
GCCCCGGCGCTCGCTCTGCCTGTAGCCAGGATGCAGCTCCCAGGCCCTGGTCTGCGCTCA
TTTCATCCTCTGGCTTCCTCACTGCCCTGTGACTTCCACCTGCTCAACCTACGTACGCTC
CAGGCTGAGGAGGACACCCTACCCTCGGCGGAGACCGCACTCATCTTACACCGCAAGGGT
TTTGACTGCGGCCTGGAGGCCAAGAACTTGGGCTTCAACTGCACCACAAGCCAAGGCAAG
GTAGCCCTGGGCAGCCTTTTCCATGGCCTGGATGTGGTATTCCTTCAGCCAACCTCCTTG
ACGTTACTGTACCCTCTGGCCTCCCCGTCCAACAGCACTGACGTCTATTTGGAGCCCATG
GAGATTGCTACCTTTCGCCTCCGCTTGGGTTAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:6825
Chromosome Location15
LocusNot Available
References
  1. Misago M, Liao YF, Kudo S, Eto S, Mattei MG, Moremen KW, Fukuda MN: Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme. Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11766-70. 8524845
  2. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. 14702039
  3. Zody MC, Garber M, Sharpe T, Young SK, Rowen L, O'Neill K, Whittaker CA, Kamal M, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Kodira CD, Madan A, Qin S, Yang X, Abbasi N, Abouelleil A, Arachchi HM, Baradarani L, Birditt B, Bloom S, Bloom T, Borowsky ML, Burke J, Butler J, Cook A, DeArellano K, DeCaprio D, Dorris L 3rd, Dors M, Eichler EE, Engels R, Fahey J, Fleetwood P, Friedman C, Gearin G, Hall JL, Hensley G, Johnson E, Jones C, Kamat A, Kaur A, Locke DP, Madan A, Munson G, Jaffe DB, Lui A, Macdonald P, Mauceli E, Naylor JW, Nesbitt R, Nicol R, O'Leary SB, Ratcliffe A, Rounsley S, She X, Sneddon KM, Stewart S, Sougnez C, Stone SM, Topham K, Vincent D, Wang S, Zimmer AR, Birren BW, Hood L, Lander ES, Nusbaum C: Analysis of the DNA sequence and duplication history of human chromosome 15. Nature. 2006 Mar 30;440(7084):671-5. 16572171
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. 15489334
  5. Hillman RT, Green RE, Brenner SE: An unappreciated role for RNA surveillance. Genome Biol. 2004;5(2):R8. Epub 2004 Feb 2. 14759258