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NameBranched-chain-amino-acid aminotransferase, cytosolic
Synonyms
  • 2.6.1.42
  • BCAT(c)
  • BCT1
  • ECA39
  • Protein ECA39
Gene NameBCAT1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037033|Branched-chain-amino-acid aminotransferase, cytosolic
MKDCSNGCSAECTGEGGSKEVVGTFKAKDLIVTPATILKEKPDPNNLVFGTVFTDHMLTV
EWSSEFGWEKPHIKPLQNLSLHPGSSALHYAVELFEGLKAFRGVDNKIRLFQPNLNMDRM
YRSAVRATLPVFDKEELLECIQQLVKLDQEWVPYSTSASLYIRPTFIGTEPSLGVKKPTK
ALLFVLLSPVGPYFSSGTFNPVSLWANPKYVRAWKGGTGDCKMGGNYGSSLFAQCEAVDN
GCQQVLWLYGEDHQITEVGTMNLFLYWINEDGEEELATPPLDGIILPGVTRRCILDLAHQ
WGEFKVSERYLTMDDLTTALEGNRVREMFGSGTACVVCPVSDILYKGETIHIPTMENGPK
LASRILSKLTDIQYGREESDWTIVLS
Number of residues386
Molecular Weight42965.815
Theoretical pI4.95
GO Classification
Functions
  • L-isoleucine transaminase activity
  • L-leucine transaminase activity
  • L-valine transaminase activity
  • branched-chain-amino-acid transaminase activity
Processes
  • G1/S transition of mitotic cell cycle
  • branched-chain amino acid biosynthetic process
  • cell proliferation
  • cellular nitrogen compound metabolic process
  • small molecule metabolic process
  • branched-chain amino acid catabolic process
Components
  • mitochondrion
  • cytosol
General FunctionL-valine transaminase activity
Specific FunctionCatalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID1036780
UniProtKB IDP54687
UniProtKB Entry NameBCAT1_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0010364|Branched-chain-amino-acid aminotransferase, cytosolic (BCAT1)
ATGAAGGATTGCAGTAACGGATGCTCCGCAGAGTGTACCGGAGAAGGAGGATCAAAAGAG
GTGGTGGGGACTTTTAAGGCTAAAGACCTAATAGTCACACCAGCTACCATTTTAAAGGAA
AAACCAGACCCCAATAATCTGGTTTTTGGAACTGTGTTCACGGATCATATGCTGACGGTG
GAGTGGTCCTCAGAGTTTGGATGGGAGAAACCTCATATCAAGCCTCTTCAGAACCTGTCA
TTGCACCCTGGCTCATCAGCTTTGCACTATGCAGTGGAAGTATTTGACAAAGAAGAGCTC
TTAGAGTGTATTCAACAGCTTGTGAAATTGGATCAAGAATGGGTCCCATATTCAACATCT
GCTAGTCTGTATATTCGTCCTACATTCATTGGAACTGAGCCTTCTCTTGGAGTCAAGAAG
CCTACCAAAGCCCTGCTCTTTGTACTCTTGAGCCCAGTGGGACCTTATTTTTCAAGTGGA
ACCTTTAATCCAGTGTCCCTGTGGGCCAATCCCAAGTATGTAAGAGCCTGGAAAGGTGGA
ACTGGGGACTGCAAGATGGGAGGGAATTACGGCTCATCTCTTTTTGCCCAATGTGAAGCA
GTAGATAATGGGTGTCAGCAGGTCCTGTGGCTCTATGGAGAGGACCATCAGATCACTGAA
GTGGGAACTATGAATCTTTTTCTTTACTGGATAAATGAAGATGGAGAAGAAGAACTGGCA
ACTCCTCCACTAGATGGCATCATTCTTCCAGGAGTGACAAGGCGGTGCATTCTGGACCTG
GCACATCAGTGGGGTGAATTTAAGGTGTCAGAGAGATACCTCACCATGGATGACTTGACA
ACAGCCCTGGAGGGGAACAGAGTGAGAGAGATGTTTGGCTCTGGTACAGCCTGTGTTGTT
TGCCCAGTTTCTGATATACTGTACAAAGGCGAGACAATACACATTCCAACTATGGAGAAT
GGTCCTAAGCTGGCAAGCCGCATCTTGAGCAAATTAACTGATATCCAGTATGGAAGAGAA
GAGAGCGACTGGACAATTGTGCTATCCTGA
GenBank Gene IDU21551
GeneCard IDNot Available
GenAtlas IDBCAT1
HGNC IDHGNC:976
Chromosome Location12
Locus12pter-q12
References
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