Tmic
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NameSodium/potassium-transporting ATPase subunit beta-3
Synonyms
  • ATPB-3
  • Sodium/potassium-dependent ATPase subunit beta-3
Gene NameATP1B3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0008794|Sodium/potassium-transporting ATPase subunit beta-3
MTKNEKKSLNQSLAEWKLFIYNPTTGEFLGRTAKSWGLILLFYLVFYGFLAALFSFTMWV
MLQTLNDEVPKYRDQIPSPGLMVFPKPVTALEYTFSRSDPTSYAGYIEDLKKFLKPYTLE
EQKNLTVCPDGALFEQKGPVYVACQFPISLLQACSGMNDPDFGYSQGNPCILVKMNRIIG
LKPEGVPRIDCVSKNEDIPNVAVYPHNGMIDLKYFPYYGKKLHVGYLQPLVAVQVSFAPN
NTGKEVTVECKIDGSANLKSQDDRDKFLGRVMFKITARA
Number of residues279
Molecular Weight31512.34
Theoretical pINot Available
GO Classification
Functions
  • sodium
  • ATPase binding
  • ATPase activator activity
Processes
  • positive regulation of potassium ion import
  • establishment or maintenance of transmembrane electrochemical gradient
  • positive regulation of potassium ion transmembrane transporter activity
  • sodium ion export from cell
  • transmembrane transport
  • leukocyte migration
  • cellular potassium ion homeostasis
  • ion transmembrane transport
  • cellular sodium ion homeostasis
  • protein localization to plasma membrane
  • membrane repolarization
  • protein stabilization
  • positive regulation of ATPase activity
  • transport
  • potassium ion import
  • positive regulation of sodium ion export from cell
  • blood coagulation
  • ATP hydrolysis coupled transmembrane transport
Components
  • extracellular exosome
  • melanosome
  • caveola
  • sodium
  • plasma membrane
General FunctionSodium:potassium-exchanging atpase activity
Specific FunctionThis is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known.
Pfam Domain Function
Transmembrane Regions36-56
GenBank Protein IDNot Available
UniProtKB IDP54709
UniProtKB Entry NameAT1B3_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0017597|Sodium/potassium-transporting ATPase subunit beta-3 (ATP1B3)
ATGACGAAGAACGAGAAGAAGTCCCTCAACCAGAGCCTGGCCGAGTGGAAGCTCTTCATC
TACAACCCGACCACCGGAGAATTCCTGGGGCGCACCGCCAAGAGCTGGGGTTTGATCTTG
CTCTTCTACCTAGTTTTTTATGGGTTCCTGGCTGCACTCTTCTCATTCACGATGTGGGTT
ATGCTTCAGACTCTCAACGATGAGGTTCCAAAATACCGTGACCAGATTCCTAGCCCAGGA
CTCATGGTTTTTCCAAAACCAGTGACCGCATTGGAATATACATTCAGTAGGTCTGATCCA
ACTTCGTATGCAGGGTACATTGAAGACCTTAAGAAGTTTCTAAAACCATATACTTTAGAA
GAACAGAAGAACCTCACAGTCTGTCCTGATGGAGCACTTTTTGAACAGAAGGGTCCAGTT
TATGTTGCATGTCAGTTTCCTATTTCATTACTTCAAGCATGCAGTGGTATGAATGATCCT
GATTTTGGCTATTCTCAAGGAAACCCTTGTATTCTTGTGAAAATGAACAGAATAATTGGA
TTAAAGCCTGAAGGAGTGCCAAGGATAGATTGTGTTTCAAAGAATGAAGATATACCAAAT
GTAGCAGTTTATCCTCATAATGGAATGATAGACTTAAAATATTTCCCATATTATGGGAAA
AAACTGCATGTTGGGTATCTACAGCCATTGGTTGCTGTTCAGGTCAGCTTTGCTCCTAAC
AACACTGGGAAAGAAGTAACAGTTGAGTGCAAGATTGATGGATCAGCCAACCTAAAAAGT
CAGGATGATCGTGACAAGTTTTTGGGACGAGTTATGTTCAAAATCACAGCACGTGCATAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:806
Chromosome Location3
LocusNot Available
References
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