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NameAdenylate kinase 2, mitochondrial
Synonyms
  • 2.7.4.3
  • Adenylate monophosphate kinase
  • ADK2
  • AK 2
  • ATP-AMP transphosphorylase 2
  • ATP:AMP phosphotransferase
Gene NameAK2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009398|Adenylate kinase 2, mitochondrial
MAPSVPAAEPEYPKGIRAVLLGPPGAGKGTQAPRLAENFCVCHLATGDMLRAMVASGSEL
GKKLKATMDAGKLVSDEMVVELIEKNLETPLCKNGFLLDGFPRTVRQAEMLDDLMEKRKE
KLDSVIEFSIPDSLLIRRITGRLIHPKSGRSYHEEFNPPKEPMKDDITGEPLIRRSDDNE
KALKIRLQAYHTQTTPLIEYYRKRGIHSAIDASQTPDVVFASILAAFSKATCKDLVMFI
Number of residues239
Molecular Weight26477.44
Theoretical pINot Available
GO Classification
Functions
  • ATP binding
  • adenylate kinase activity
Processes
  • small molecule metabolic process
  • nucleobase-containing small molecule metabolic process
  • nucleobase-containing small molecule interconversion
  • ATP metabolic process
  • nucleotide phosphorylation
  • AMP metabolic process
  • ADP biosynthetic process
Components
  • mitochondrial inner membrane
  • extracellular exosome
  • mitochondrial intermembrane space
  • sperm mitochondrial sheath
General FunctionAtp binding
Specific FunctionCatalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP54819
UniProtKB Entry NameKAD2_HUMAN
Cellular LocationMitochondrion intermembrane space
Gene sequence
>lcl|BSEQ0017449|Adenylate kinase 2, mitochondrial (AK2)
ATGGCTCCCAGCGTGCCAGCGGCAGAACCCGAGTATCCTAAAGGCATCCGGGCCGTGCTG
CTGGGGCCTCCCGGGGCCGGTAAAGGGACCCAGGCACCCAGATTGGCTGAAAACTTCTGT
GTCTGCCATTTAGCTACTGGGGACATGCTGAGGGCCATGGTGGCTTCTGGCTCAGAGCTA
GGAAAAAAGCTGAAGGCAACTATGGATGCTGGGAAACTGGTGAGTGATGAAATGGTAGTG
GAGCTCATTGAGAAGAATTTGGAGACCCCCTTGTGCAAAAATGGTTTTCTTCTGGATGGC
TTCCCTCGGACTGTGAGGCAGGCAGAAATGCTCGATGACCTCATGGAGAAGAGGAAAGAG
AAGCTTGATTCTGTGATTGAATTCAGCATCCCAGACTCTCTGCTGATTCACCCCAAGAGT
GGCCGTTCCTACCACGAGGAGTTCAACCCTCCAAAAGAGCCCATGAAAGATGACATCACC
GGGGAACCCTTGATCCGTCGATCAGATGATAATGAAAAGGCCTTGAAAATCCGCCTGCAA
GCCTACCACACTCAAACCACCCCACTCATAGAGTACTACAGGAAACGGGGGATCCACTCC
GCCATCGATGCATCCCAGACCCCCGATGTCGTGTTCGCAAGCATCCTAGCAGCCTTCTCC
AAAGCCACATCCTAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:362
Chromosome Location1
LocusNot Available
References
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  2. Lee Y, Kim JW, Lee SM, Kim HJ, Lee KS, Park C, Choe IS: Cloning and expression of human adenylate kinase 2 isozymes: differential expression of adenylate kinase 1 and 2 in human muscle tissues. J Biochem. 1998 Jan;123(1):47-54. 9504408
  3. Noma T, Song S, Yoon YS, Tanaka S, Nakazawa A: cDNA cloning and tissue-specific expression of the gene encoding human adenylate kinase isozyme 2. Biochim Biophys Acta. 1998 Jan 7;1395(1):34-9. 9434148
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