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NameTyrosine-protein phosphatase non-receptor type 5
Synonyms
  • 3.1.3.48
  • Neural-specific protein-tyrosine phosphatase
  • STEP
  • Striatum-enriched protein-tyrosine phosphatase
Gene NamePTPN5
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009003|Tyrosine-protein phosphatase non-receptor type 5
MNYEGARSERENHAADDSEGGALDMCCSERLPGLPQPIVMEALDEAEGLQDSQREMPPPP
PPSPPSDPAQKPPPRGAGSHSLTVRSSLCLFAASQFLLACGVLWFSGYGHIWSQNATNLV
SSLLTLLKQLEPTAWLDSGTWGVPSLLLVFLSVGLVLVTTLVWHLLRTPPEPPTPLPPED
RRQSVSRQPSFTYSEWMEEKIEDDFLDLDPVPETPVFDCVMDIKPEADPTSLTVKSMGLQ
ERRGSNVSLTLDMCTPGCNEEGFGYLMSPREESAREYLLSASRVLQAEELHEKALDPFLL
QAEFFEIPMNFVDPKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDDPLSSYINANYIR
GYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNEKCTEYWPEEQVAYD
GVEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEE
AAQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQ
TCEQYQFVHHVMSLYEKQLSHQSPE
Number of residues565
Molecular Weight63537.53
Theoretical pINot Available
GO Classification
Functions
  • phosphotyrosine binding
  • protein tyrosine phosphatase activity
Processes
  • peptidyl-tyrosine dephosphorylation
  • protein dephosphorylation
Components
  • endoplasmic reticulum membrane
  • integral component of membrane
General FunctionProtein tyrosine phosphatase activity
Specific FunctionMay regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors.
Pfam Domain Function
Transmembrane Regions88-108 146-166
GenBank Protein IDNot Available
UniProtKB IDP54829
UniProtKB Entry NamePTN5_HUMAN
Cellular LocationEndoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0019698|Tyrosine-protein phosphatase non-receptor type 5 (PTPN5)
ATGAATTATGAGGGAGCCAGGAGTGAGAGAGAGAACCACGCTGCTGATGACTCCGAGGGA
GGGGCCCTGGACATGTGCTGCAGTGAGAGGCTACCGGGTCTCCCCCAGCCGATAGTGATG
GAGGCACTGGACGAGGCTGAAGGGCTCCAGGACTCACAGAGAGAGATGCCGCCACCCCCT
CCTCCCTCGCCGCCCTCAGATCCAGCTCAGAAGCCACCACCTCGAGGCGCTGGGAGCCAC
TCCCTCACTGTCAGGAGCAGCCTGTGCCTGTTCGCTGCCTCACAGTTCCTGCTGGAACCC
ACGGCCTGGCTTGACTCTGGGACGTGGGGAGTCCCCAGTCTGCTGCTGGTCTTTCTGTCC
GTGGGCCTGGTCCTCGTTACCACCCTGGTGTGGCACCTCCTGAGGACACCCCCAGAGCCA
CCCACCCCACTGCCCCCTGAGGACAGGCGCCAGTCAGTGAGCCGCCAGCCCTCCTTCACC
TACTCAGAGTGGATGGAGGAGAAGATCGAGGATGACTTCCTGGACCTCGACCCGGTGCCC
GAGACTCCTGTGTTTGATTGTGTGATGGACATCAAGCCTGAGGCTGACCCCACCTCACTC
ACCGTCAAGTCCATGGGTCTGCAGGAGAGGAGGGGTTCCAATGTCTCCCTGACCCTGGAC
ATGTGCACTCCGGGCTGCAACGAGGAGGGCTTTGGCTATCTCATGTCCCCACGTGAGGAG
TCCGCCCGCGAGTACCTGCTCAGCGCCTCCCGTGTCCTCCAAGCAGAAGAGCTTCATGAA
AAGGCCCTGGACCCTTTCCTGCTGCAGGCGGAATTCTTTGAAATCCCCATGAACTTTGTG
GATCCGAAAGAGTACGACATCCCTGGGCTGGTGCGGAAGAACCGGTACAAAACCATACTT
CCCAACCCTCACAGCAGAGTGTGTCTGACCTCACCAGACCCTGACGACCCTCTGAGTTCC
TACATCAATGCCAACTACATCCGGGGCTATGGTGGGGAGGAGAAGGTGTACATCGCCACT
CAGGGACCCATCGTCAGCACGGTCGCCGACTTCTGGCGCATGGTGTGGCAGGAGCACACG
CCCATCATTGTCATGATCACCAACATCGAGGAGATGAACGAGAAATGCACCGAGTATTGG
CCGGAGGAGCAGGTGGCGTACGACGGTGTTGAGATCACTGTGCAGAAAGTCATTCACACG
GAGGATTACCGGCTGCGACTCATCTCCCTCAAGAGTGGGACTGAGGAGCGAGGCCTGAAG
CATTACTGGTTCACATCCTGGCCCGACCAGAAGACCCCAGACCGGGCCCCCCCACTCCTG
CACCTGGTGCGGGAGGTGGAGGAGGCAGCCCAGCAGGAGGGGCCCCACTGTGCCCCCATC
ATCGTCCACTGCAGTGCAGGGATTGGGAGGACCGGCTGCTTCATTGCCACCAGCATCTGC
TGCCAGCAGCTGCGGCAGGAGGGTGTGGTGGACATCCTGAAGACCACGTGCCAGCTCCGT
CAGGACAGGGGCGGCATGATCCAGACATGCGAGCAGTACCAGTTTGTGCACCACGTCATG
AGCCTCTACGAAAAGCAGCTGTCCCACCAGTCCCCAGAATGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:9657
Chromosome Location11
LocusNot Available
References
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