NamePhosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Synonyms
  • 3.1.3.16
  • MMAC1
  • Mutated in multiple advanced cancers 1
  • Phosphatase and tensin homolog
  • TEP1
Gene NamePTEN
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009278|Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSK
HKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVA
AIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSY
LLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMY
FEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEI
DSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEAS
SSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV
Number of residues403
Molecular Weight47165.92
Theoretical pINot Available
GO Classification
Functions
  • magnesium ion binding
  • inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
  • enzyme binding
  • phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
  • phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
  • protein tyrosine/serine/threonine phosphatase activity
  • phosphatidylinositol-3-phosphatase activity
  • protein serine/threonine phosphatase activity
  • PDZ domain binding
  • anaphase-promoting complex binding
  • lipid binding
  • phosphoprotein phosphatase activity
  • identical protein binding
  • protein tyrosine phosphatase activity
Processes
  • regulation of axon regeneration
  • phosphatidylinositol-mediated signaling
  • prostate gland growth
  • protein stabilization
  • apoptotic process
  • prepulse inhibition
  • synapse maturation
  • positive regulation of ERK1 and ERK2 cascade
  • phosphatidylinositol biosynthetic process
  • fibroblast growth factor receptor signaling pathway
  • multicellular organismal response to stress
  • negative regulation of organ growth
  • cell proliferation
  • cellular response to hypoxia
  • response to ATP
  • heart development
  • negative regulation of cell aging
  • memory
  • response to glucose
  • central nervous system myelin maintenance
  • negative regulation of apoptotic process
  • negative regulation of epithelial cell proliferation
  • male mating behavior
  • activation of APC-Cdc20 complex activity
  • gene expression
  • negative regulation of cell migration
  • response to arsenic-containing substance
  • negative regulation of protein kinase B signaling
  • negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
  • negative regulation of cell proliferation
  • positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
  • small molecule metabolic process
  • response to nutrient
  • regulation of synaptic transmission, GABAergic
  • negative regulation of dendritic spine morphogenesis
  • neurotrophin TRK receptor signaling pathway
  • regulation of protein stability
  • transcription initiation from RNA polymerase II promoter
  • phospholipid metabolic process
  • cardiac muscle tissue development
  • negative regulation of cell size
  • negative regulation of ribosome biogenesis
  • positive regulation of cell proliferation
  • negative regulation of myelination
  • dentate gyrus development
  • response to ethanol
  • endothelial cell migration
  • neuron-neuron synaptic transmission
  • negative regulation of synaptic vesicle clustering
  • locomotory behavior
  • negative regulation of phagocytosis
  • regulation of myeloid cell apoptotic process
  • response to zinc ion
  • adult behavior
  • negative regulation of axonogenesis
  • postsynaptic density assembly
  • negative regulation of protein phosphorylation
  • regulation of B cell apoptotic process
  • cell migration
  • T cell receptor signaling pathway
  • central nervous system development
  • locomotor rhythm
  • regulation of cellular component size
  • peptidyl-tyrosine dephosphorylation
  • negative regulation of G1/S transition of mitotic cell cycle
  • epidermal growth factor receptor signaling pathway
  • protein dephosphorylation
  • rhythmic synaptic transmission
  • phosphatidylinositol dephosphorylation
  • protein kinase B signaling
  • inositol phosphate dephosphorylation
  • negative regulation of excitatory postsynaptic potential
  • innate immune response
  • aging
  • synapse assembly
  • dendritic spine morphogenesis
  • response to drug
  • angiogenesis
  • inositol phosphate metabolic process
  • platelet-derived growth factor receptor signaling pathway
  • positive regulation of apoptotic signaling pathway
  • positive regulation of excitatory postsynaptic potential
  • regulation of cyclin-dependent protein serine/threonine kinase activity
  • long term synaptic depression
  • canonical Wnt signaling pathway
  • negative regulation of phosphatidylinositol 3-kinase signaling
  • Fc-epsilon receptor signaling pathway
  • learning or memory
  • regulation of neuron projection development
  • maternal behavior
  • central nervous system neuron axonogenesis
  • long-term synaptic potentiation
  • brain morphogenesis
  • social behavior
  • positive regulation of sequence-specific DNA binding transcription factor activity
  • forebrain morphogenesis
  • response to estradiol
  • negative regulation of focal adhesion assembly
  • presynaptic membrane assembly
Components
  • dendritic spine
  • myelin sheath adaxonal region
  • cytoplasmic side of plasma membrane
  • Schmidt-Lanterman incisure
  • cytoplasm
  • cytosol
  • mitochondrion
  • nucleoplasm
  • extracellular region
  • neuron projection
  • postsynaptic membrane
  • apical plasma membrane
  • nucleus
  • plasma membrane
  • PML body
  • cell projection
General FunctionProtein tyrosine/serine/threonine phosphatase activity
Specific FunctionTumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement.Isoform alpha: Functional kinase, like isoform 1 it antagonizes the PI3K-AKT/PKB signaling pathway. Plays a role in mitochondrial energetic metabolism by promoting COX activity and ATP production, via collaboration with isoform 1 in increasing protein levels of PINK1.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP60484
UniProtKB Entry NamePTEN_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0021732|Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)
ATGACAGCCATCATCAAAGAGATCGTTAGCAGAAACAAAAGGAGATATCAAGAGGATGGA
TTCGACTTAGACTTGACCTATATTTATCCAAACATTATTGCTATGGGATTTCCTGCAGAA
AGACTTGAAGGCGTATACAGGAACAATATTGATGATGTAGTAAGGTTTTTGGATTCAAAG
CATAAAAACCATTACAAGATATACAATCTTTGTGCTGAAAGACATTATGACACCGCCAAA
TTTAATTGCAGAGTTGCACAATATCCTTTTGAAGACCATAACCCACCACAGCTAGAACTT
ATCAAACCCTTTTGTGAAGATCTTGACCAATGGCTAAGTGAAGATGACAATCATGTTGCA
GCAATTCACTGTAAAGCTGGAAAGGGACGAACTGGTGTAATGATATGTGCATATTTATTA
CATCGGGGCAAATTTTTAAAGGCACAAGAGGCCCTAGATTTCTATGGGGAAGTAAGGACC
AGAGACAAAAAGGGAGTAACTATTCCCAGTCAGAGGCGCTATGTGTATTATTATAGCTAC
CTGTTAAAGAATCATCTGGATTATAGACCAGTGGCACTGTTGTTTCACAAGATGATGTTT
GAAACTATTCCAATGTTCAGTGGCGGAACTTGCAATCCTCAGTTTGTGGTCTGCCAGCTA
AAGGTGAAGATATATTCCTCCAATTCAGGACCCACACGACGGGAAGACAAGTTCATGTAC
TTTGAGTTCCCTCAGCCGTTACCTGTGTGTGGTGATATCAAAGTAGAGTTCTTCCACAAA
CAGAACAAGATGCTAAAAAAGGACAAAATGTTTCACTTTTGGGTAAATACATTCTTCATA
CCAGGACCAGAGGAAACCTCAGAAAAAGTAGAAAATGGAAGTCTATGTGATCAAGAAATC
GATAGCATTTGCAGTATAGAGCGTGCAGATAATGACAAGGAATATCTAGTACTTACTTTA
ACAAAAAATGATCTTGACAAAGCAAATAAAGACAAAGCCAACCGATACTTTTCTCCAAAT
TTTAAGGTGAAGCTGTACTTCACAAAAACAGTAGAGGAGCCGTCAAATCCAGAGGCTAGC
AGTTCAACTTCTGTAACACCAGATGTTAGTGACAATGAACCTGATCATTATAGATATTCT
GACACCACTGACTCTGATCCAGAGAATGAACCTTTTGATGAAGATCAGCATACACAAATT
ACAAAAGTCTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:9588
Chromosome Location10
LocusNot Available
References
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