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NameSomatostatin
Synonyms
  • Growth hormone release-inhibiting factor
Gene NameSST
OrganismHuman
Amino acid sequence
>lcl|BSEQ0010750|Somatostatin
MLSCRLQCALAALSIVLALGCVTGAPSDPRLRQFLQKSLAAAAGKQELAKYFLAELLSEP
NQTENDALEPEDLSQAAEQDEMRLELQRSANSNPAMAPRERKAGCKNFFWKTFTSC
Number of residues116
Molecular Weight12735.395
Theoretical pI5.18
GO Classification
Functions
  • hormone activity
Processes
  • regulation of cell migration
  • digestion
  • negative regulation of cell proliferation
  • G-protein coupled receptor signaling pathway
  • cell surface receptor signaling pathway
  • response to amino acid
  • response to nutrient
  • response to acidic pH
  • response to heat
  • response to steroid hormone
  • hormone-mediated apoptotic signaling pathway
  • response to drug
  • hyperosmotic response
  • cell-cell signaling
  • synaptic transmission
Components
  • neuronal cell body
  • extracellular region
  • extracellular space
General FunctionHormone activity
Specific FunctionSomatostatin inhibits the release of somatotropin.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID338288
UniProtKB IDP61278
UniProtKB Entry NameSMS_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0010751|Somatostatin (SST)
ATGCTGTCCTGCCGCCTCCAGTGCGCGCTGGCTGCGCTGTCCATCGTCCTGGCCCTGGGC
TGTGTCACCGGCGCTCCCTCGGACCCCAGACTCCGTCAGTTTCTGCAGAAGTCCCTGGCT
GCTGCCGCGGGGAAGCAGGAACTGGCCAAGTACTTCTTGGCAGAGCTGCTGTCTGAACCC
AACCAGACGGAGAATGATGCCCTGGAACCTGAAGATCTGTCCCAGGCTGCTGAGCAGGAT
GAAATGAGGCTTGAGCTGCAGAGATCTGCTAACTCAAACCCGGCTATGGCACCCCGAGAA
CGCAAAGCTGGCTGCAAGAATTTCTTCTGGAAGACTTTCACATCCTGTTAG
GenBank Gene IDJ00306
GeneCard IDNot Available
GenAtlas IDSST
HGNC IDHGNC:11329
Chromosome Location3
Locus3q28
References
  1. Shen LP, Pictet RL, Rutter WJ: Human somatostatin I: sequence of the cDNA. Proc Natl Acad Sci U S A. 1982 Aug;79(15):4575-9. 6126875
  2. Shen LP, Rutter WJ: Sequence of the human somatostatin I gene. Science. 1984 Apr 13;224(4645):168-71. 6142531
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  5. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. 24275569