Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

NameSerine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Synonyms
  • 3.1.3.16
  • PP2A-alpha
  • Replication protein C
  • RP-C
Gene NamePPP2CA
OrganismHuman
Amino acid sequence
>lcl|BSEQ0004568|Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
MDEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHG
QFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHES
RQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHI
RALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRA
HQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHV
TRRTPDYFL
Number of residues309
Molecular Weight35593.93
Theoretical pI5.22
GO Classification
Functions
  • phosphoprotein phosphatase activity
  • metal ion binding
  • protein C-terminus binding
  • GABA receptor binding
Processes
  • negative regulation of cell growth
  • negative regulation of tyrosine phosphorylation of STAT protein
  • response to organic substance
  • positive regulation of protein serine/threonine kinase activity
  • second-messenger-mediated signaling
  • regulation of growth
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • regulation of DNA replication
  • RNA splicing
  • regulation of cell adhesion
  • ceramide metabolic process
  • regulation of cell differentiation
  • inactivation of MAPK activity
  • mitotic nuclear envelope reassembly
  • regulation of Wnt signaling pathway
  • meiotic cell cycle
  • regulation of transcription, DNA-templated
  • apoptotic process
  • mesoderm development
  • protein dephosphorylation
  • negative regulation of epithelial to mesenchymal transition
Components
  • microtubule cytoskeleton
  • nucleus
  • plasma membrane
  • spindle pole
  • chromosome, centromeric region
  • protein phosphatase type 2A complex
  • cytosol
  • extracellular exosome
  • mitochondrion
  • membrane
General FunctionPP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.
Specific FunctionGaba receptor binding
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID36120
UniProtKB IDP67775
UniProtKB Entry NamePP2AA_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0016755|Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA)
ATGGACGAGAAGGTGTTCACCAAGGAGCTGGACCAGTGGATCGAGCAGCTGAACGAGTGC
AAGCAGCTGTCCGAGTCCCAGGTCAAGAGCCTCTGCGAGAAGGCTAAAGAAATCCTGACA
AAAGAATCCAACGTGCAAGAGGTTCGATGTCCAGTTACTGTCTGTGGAGATGTGCATGGG
CAATTTCATGATCTCATGGAACTGTTTAGAATTGGTGGCAAATCACCAGATACAAATTAC
TTGTTTATGGGAGATTATGTTGACAGAGGATATTATTCAGTTGAAACAGTTACACTGCTT
GTAGCTCTTAAGGTTCGTTACCGTGAACGCATCACCATTCTTCGAGGGAATCATGAGAGC
AGACAGATCACACAAGTTTATGGTTTCTATGATGAATGTTTAAGAAAATATGGAAATGCA
AATGTTTGGAAATATTTTACAGATCTTTTTGACTATCTTCCTCTCACTGCCTTGGTGGAT
GGGCAGATCTTCTGTCTACATGGTGGTCTCTCGCCATCTATAGATACACTGGATCATATC
AGAGCACTTGATCGCCTACAAGAAGTTCCCCATGAGGGTCCAATGTGTGACTTGCTGTGG
TCAGATCCAGATGACCGTGGTGGTTGGGGTATATCTCCTCGAGGAGCTGGTTACACCTTT
GGGCAAGATATTTCTGAGACATTTAATCATGCCAATGGCCTCACGTTGGTGTCTAGAGCT
CACCAGCTAGTGATGGAGGGATATAACTGGTGCCATGACCGGAATGTAGTAACGATTTTC
AGTGCTCCAAACTATTGTTATCGTTGTGGTAACCAAGCTGCAATCATGGAACTTGACGAT
ACTCTAAAATACTCTTTCTTGCAGTTTGACCCAGCACCTCGTAGAGGCGAGCCACATGTT
ACTCGTCGTACCCCAGACTACTTCCTGTAA
GenBank Gene IDX12646
GeneCard IDNot Available
GenAtlas IDPPP2CA
HGNC IDHGNC:9299
Chromosome Location5
Locus5q31.1
References
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