Canmetcon
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NameGlutathione S-transferase omega-1
Synonyms
  • 2.5.1.18
  • Glutathione S-transferase omega 1-1
  • Glutathione-dependent dehydroascorbate reductase
  • GSTO 1-1
  • GSTO-1
  • GSTTLP28
  • MMA(V) reductase
  • Monomethylarsonic acid reductase
  • S-(Phenacyl)glutathione reductase
  • SPG-R
Gene NameGSTO1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001626|Glutathione S-transferase omega-1
MSGESARSLGKGSAPPGPVPEGSIRIYSMRFCPFAERTRLVLKAKGIRHEVININLKNKP
EWFFKKNPFGLVPVLENSQGQLIYESAITCEYLDEAYPGKKLLPDDPYEKACQKMILELF
SKVPSLVGSFIRSQNKEDYAGLKEEFRKEFTKLEEVLTNKKTTFFGGNSISMIDYLIWPW
FERLEAMKLNECVDHTPKLKLWMAAMKEDPTVSALLTSEKDWQGFLELYLQNSPEACDYG
L
Number of residues241
Molecular Weight27565.6
Theoretical pI6.54
GO Classification
Functions
  • glutathione dehydrogenase (ascorbate) activity
  • methylarsonate reductase activity
  • oxidoreductase activity
  • glutathione transferase activity
Processes
  • methylation
  • xenobiotic catabolic process
  • oxidation-reduction process
  • cellular response to arsenic-containing substance
  • xenobiotic metabolic process
  • regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
  • L-ascorbic acid biosynthetic process
  • L-ascorbic acid metabolic process
  • negative regulation of ryanodine-sensitive calcium-release channel activity
  • glutathione metabolic process
  • regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
  • positive regulation of ryanodine-sensitive calcium-release channel activity
  • small molecule metabolic process
  • glutathione derivative biosynthetic process
  • positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
Components
  • extracellular exosome
  • myelin sheath
  • nuclear membrane
  • cell body
  • cytoplasm
  • basement membrane
  • axon
  • cytosol
General FunctionOxidoreductase activity
Specific FunctionExhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID2393722
UniProtKB IDP78417
UniProtKB Entry NameGSTO1_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0016215|Glutathione S-transferase omega-1 (GSTO1)
ATGTCCGGGGAGTCAGCCAGGAGCTTGGGGAAGGGAAGCGCGCCCCCGGGGCCGGTCCCG
GAGGGCTCGATCCGCATCTACAGCATGAGGTTCTGCCCGTTTGCTGAGAGGACGCGTCTA
GTCCTGAAGGCCAAGGGAATCAGGCATGAAGTCATCAATATCAACCTGAAAAATAAGCCT
GAGTGGTTCTTTAAGAAAAATCCCTTTGGTCTGGTGCCAGTTCTGGAAAACAGTCAGGGT
CAGCTGATCTACGAGTCTGCCATCACCTGTGAGTACCTGGATGAAGCATACCCAGGGAAG
AAGCTGTTGCCGGATGACCCCTATGAGAAAGCTTGCCAGAAGATGATCTTAGAGTTGTTT
TCTAAGGTTCTGACTAATAAGAAGACGACCTTCTTTGGTGGCAATTCTATCTCTATGATT
GATTACCTCATCTGGCCCTGGTTTGAACGGCTGGAAGCAATGAAGTTAAATGAGTGTGTA
GACCACACTCCAAAACTGAAACTGTGGATGGCAGCCATGAAGGAAGATCCCACAGTCTCA
GCCCTGCTTACTAGTGAGAAAGACTGGCAAGGTTTCCTAGAGCTCTACTTACAGAACAGC
CCTGAGGCCTGTGACTATGGGCTCTGA
GenBank Gene IDU90313
GeneCard IDNot Available
GenAtlas IDGSTO1
HGNC IDHGNC:13312
Chromosome Location10
Locus10q25.1
References
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  2. Yu L, Kalla K, Guthrie E, Vidrine A, Klimecki WT: Genetic variation in genes associated with arsenic metabolism: glutathione S-transferase omega 1-1 and purine nucleoside phosphorylase polymorphisms in European and indigenous Americans. Environ Health Perspect. 2003 Aug;111(11):1421-7. 12928150
  3. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. 17974005
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  7. Zakharyan RA, Sampayo-Reyes A, Healy SM, Tsaprailis G, Board PG, Liebler DC, Aposhian HV: Human monomethylarsonic acid (MMA(V)) reductase is a member of the glutathione-S-transferase superfamily. Chem Res Toxicol. 2001 Aug;14(8):1051-7. 11511179
  8. Board PG, Anders MW: Glutathione transferase omega 1 catalyzes the reduction of S-(phenacyl)glutathiones to acetophenones. Chem Res Toxicol. 2007 Jan;20(1):149-54. 17226937
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  10. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. 19413330
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  13. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. 24275569
  14. Vaca Jacome AS, Rabilloud T, Schaeffer-Reiss C, Rompais M, Ayoub D, Lane L, Bairoch A, Van Dorsselaer A, Carapito C: N-terminome analysis of the human mitochondrial proteome. Proteomics. 2015 Jul;15(14):2519-24. doi: 10.1002/pmic.201400617. Epub 2015 Jun 8. 25944712
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