NameCyclic AMP-responsive element-binding protein 5
Synonyms
  • CRE-BPa
  • CREB-5
  • CREBPA
Gene NameCREB5
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009605|Cyclic AMP-responsive element-binding protein 5
MIYEESKMNLEQERPFVCSAPGCSQRFPTEDHLMIHRHKHEMTLKFPSIKTDNMLSDQTP
TPTRFLKNCEEVGLFSELDCSLEHEFRKAQEEESSKRNISMHNAVGGAMTGPGTHQLSSA
RLPNHDTNVVIQQAMPSPQSSSVITQAPSTNRQIGPVPGSLSSLLHLHNRQRQPMPASMP
GTLPNPTMPGSSAVLMPMERQMSVNSSIMGMQGPNLSNPCASPQVQPMHSEAKMRLKAAL
THHPAAMSNGNMNTMGHMMEMMGSRQDQTPHHHMHSHPHQHQTLPPHHPYPHQHQHPAHH
PHPQPHHQQNHPHHHSHSHLHAHPAHHQTSPHPPLHTGNQAQVSPATQQMQPTQTIQPPQ
PTGGRRRRVVDEDPDERRRKFLERNRAAATRCRQKRKVWVMSLEKKAEELTQTNMQLQNE
VSMLKNEVAQLKQLLLTHKDCPITAMQKESQGYLSPESSPPASPVPACSQQQVIQHNTIT
TSSSVSEVVGSSTLSQLTTHRTDLNPIL
Number of residues508
Molecular Weight56918.115
Theoretical pINot Available
GO Classification
Functions
  • metal ion binding
  • sequence-specific DNA binding
  • transcription factor activity, sequence-specific DNA binding
Processes
  • transcription from RNA polymerase II promoter
  • positive regulation of transcription, DNA-templated
Components
  • nucleus
  • extracellular exosome
General FunctionTranscription factor activity, sequence-specific dna binding
Specific FunctionBinds to the cAMP response element and activates transcription.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ02930
UniProtKB Entry NameCREB5_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0017717|Cyclic AMP-responsive element-binding protein 5 (CREB5)
ATGTTCTGCACCTCAGGAGGGAATTCAGCCTCAGTGATGTCCATGAGGCCTGTCCCAGGC
TCTCTATCTTCTCTGCTACATCTCCACAACAGACAGAGACAGCCCATGCCAGCCTCCATG
CCTGGGACCCTGCCCAACCCTACAATGCCAGGATCTTCCGCCGTCTTGATGCCAATGGAG
CGACAAATGTCAGTGAACTCCAGCATCATGGGGATGCAAGGTCCAAATCTCAGCAACCCC
TGTGCTTCTCCCCAGGTCCAGCCAATGCATTCAGAAGCCAAAATGAGGTTGAAGGCTGCA
TTGACTCACCACCCTGCTGCCATGTCAAATGGGAACATGAACACCATGGGACACATGATG
GAGATGATGGGCTCCCGGCAGGACCAGACGCCACACCATCACATGCACTCGCACCCGCAT
CAGCACCAGACACTGCCACCCCATCACCCTTACCCACACCAGCACCAGCACCCAGCACAC
CATCCTCACCCTCAACCCCATCACCAGCAGAACCATCCACATCACCACTCCCATTCCCAC
CTTCATGCACACCCAGCACATCACCAGACCTCGCCACATCCGCCCCTGCACACCGGCAAC
CAAGCACAGGTTTCACCAGCAACACAACAGATGCAGCCAACCCAGACAATACAGCCACCC
CAGCCCACAGGGGGGCGCCGGCGAAGGGTGGTAGACGAGGATCCGGACGAGAGGCGGCGG
AAATTTCTGGAACGGAACCGGGCAGCTGCCACCCGCTGCAGACAGAAGAGGAAGGTCTGG
GTGATGTCATTGGAAAAGAAAGCAGAAGAACTCACCCAGACAAACATGCAGCTTCAGAAT
GAAGTGTCTATGTTGAAAAATGAGGTGGCCCAGCTGAAACAGTTGTTGTTAACACATAAA
GACTGCCCAATAACAGCCATGCAGAAAGAATCACAAGGATATCTAAGTCCAGAGAGTAGC
CCTCCTGCTAGTCCTGTCCCAGCTTGCTCCCAGCAACAAGTCATCCAGCATAATACCATC
ACTACTTCCTCATCGGTCAGCGAGGTGGTAGGAAGCTCCACCCTCAGCCAGCTCACCACT
CACAGAACAGACCTGAATCCGATTCTTTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:16844
Chromosome Location7
LocusNot Available
References
  1. Nomura N, Zu YL, Maekawa T, Tabata S, Akiyama T, Ishii S: Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1. J Biol Chem. 1993 Feb 25;268(6):4259-66. 8440710
  2. Zu YL, Maekawa T, Nomura N, Nakata T, Ishii S: Regulation of trans-activating capacity of CRE-BPa by phorbol ester tumor promoter TPA. Oncogene. 1993 Oct;8(10):2749-58. 8378084
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