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NameProtein kinase C zeta type
Synonyms
  • 2.7.11.13
  • nPKC-zeta
  • PKC2
Gene NamePRKCZ
OrganismHuman
Amino acid sequence
>lcl|BSEQ0008674|Protein kinase C zeta type
MPSRTGPKMEGSGGRVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRLHQQHPLTLKW
VDSEGDPCTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGAR
RWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTC
RKHMDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDG
IKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTE
KHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEI
CIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAP
EILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRF
LSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQIT
DDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV
Number of residues592
Molecular Weight67659.335
Theoretical pINot Available
GO Classification
Functions
  • ATP binding
  • protein kinase activity
  • protein serine/threonine kinase activity
  • insulin receptor substrate binding
  • metal ion binding
  • potassium channel regulator activity
  • protein kinase C activity
Processes
  • neuron projection extension
  • insulin receptor signaling pathway
  • positive regulation of insulin receptor signaling pathway
  • signal transduction
  • positive regulation of interleukin-4 production
  • positive regulation of interleukin-10 secretion
  • negative regulation of apoptotic process
  • peptidyl-serine phosphorylation
  • positive regulation of interleukin-5 secretion
  • negative regulation of protein complex assembly
  • membrane hyperpolarization
  • long-term memory
  • positive regulation of T-helper 2 cell cytokine production
  • protein phosphorylation
  • blood coagulation
  • negative regulation of hydrolase activity
  • positive regulation of T-helper 2 cell differentiation
  • vascular endothelial growth factor receptor signaling pathway
  • microtubule cytoskeleton organization
  • activation of protein kinase B activity
  • positive regulation of cell proliferation
  • inflammatory response
  • protein localization to plasma membrane
  • negative regulation of peptidyl-tyrosine phosphorylation
  • vesicle transport along microtubule
  • platelet activation
  • positive regulation of excitatory postsynaptic potential
  • establishment of cell polarity
  • actin cytoskeleton reorganization
  • protein kinase C signaling
  • long-term synaptic potentiation
  • positive regulation of interleukin-13 secretion
  • positive regulation of NF-kappaB transcription factor activity
  • positive regulation of cell-matrix adhesion
  • membrane depolarization
  • positive regulation of ERK1 and ERK2 cascade
  • negative regulation of insulin receptor signaling pathway
  • transforming growth factor beta receptor signaling pathway
  • protein heterooligomerization
  • activation of phospholipase D activity
  • cell migration
  • positive regulation of glucose import
Components
  • cell-cell junction
  • bicellular tight junction
  • axon hillock
  • plasma membrane
  • microtubule organizing center
  • membrane raft
  • endosome
  • vesicle
  • apical plasma membrane
  • cell junction
  • nuclear envelope
  • nuclear matrix
  • apical cortex
  • cytosol
  • filamentous actin
  • extracellular exosome
  • myelin sheath abaxonal region
  • perinuclear region of cytoplasm
  • cell leading edge
  • cytoplasm
  • membrane
General FunctionProtein serine/threonine kinase activity
Specific FunctionCalcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Necessary and sufficient for LTP maintenance in hippocampal CA1 pyramidal cells. In vein endothelial cells treated with the oxidant peroxynitrite, phosphorylates STK11 leading to nuclear export of STK11, subsequent inhibition of PI3K/Akt signaling, and increased apoptosis. Phosphorylates VAMP2 in vitro (PubMed:17313651).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ05513
UniProtKB Entry NameKPCZ_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0013346|Protein kinase C zeta type (PRKCZ)
ATGGATTCTGTCATGCCTTCCCAAGAGCCTCCAGTAGACGACAAGAACGAGGACGCCGAC
CTTCCTTCCGAGGAGACAGATGGAATTGCTTACATTTCCTCATCCCGGAAGCATGACAGC
ATTAAAGACGACTCGGAGGACCTTAAGCCAGTTATCGATGGGATGGATGGAATCAAAATC
TCTCAGGGGCTTGGGCTGCAGGACTTTGACCTAATCAGAGTCATCGGGCGCGGGAGCTAC
GCCAAGGTTCTCCTGGTGCGGTTGAAGAAGAATGACCAAATTTACGCCATGAAAGTGGTG
AAGAAAGAGCTGGTGCATGATGACGAGGATATTGACTGGGTACAGACAGAGAAGCACGTG
TTTGAGCAGGCATCCAGCAACCCCTTCCTGGTCGGATTACACTCCTGCTTCCAGACGACA
AGTCGGTTGTTCCTGGTCATTGAGTACGTCAACGGCGGGGACCTGATGTTCCACATGCAG
AGGCAGAGGAAGCTCCCTGAGGAGCACGCCAGGTTCTACGCGGCCGAGATCTGCATCGCC
CTCAACTTCCTGCACGAGAGGGGGATCATCTACAGGGACCTGAAGCTGGACAACGTCCTC
CTGGATGCGGACGGGCACATCAAGCTCACAGACTACGGCATGTGCAAGGAAGGCCTGGGC
CCTGGTGACACAACGAGCACTTTCTGCGGAACCCCGAATTACATCGCCCCCGAAATCCTG
CGGGGAGAGGAGTACGGGTTCAGCGTGGACTGGTGGGCGCTGGGAGTCCTCATGTTTGAG
ATGATGGCCGGGCGCTCCCCGTTCGACATCATCACCGACAACCCGGACATGAACACAGAG
GACTACCTTTTCCAAGTGATCCTGGAGAAGCCCATCCGGATCCCCCGGTTCCTGTCCGTC
AAAGCCTCCCATGTTTTAAAAGGATTTTTAAATAAGGACCCCAAAGAGAGGCTCGGCTGC
CGGCCACAGACTGGATTTTCTGACATCAAGTCCCACGCGTTCTTCCGCAGCATAGACTGG
GACTTGCTGGAGAAGAAGCAGGCGCTCCCTCCATTCCAGCCACAGATCACAGACGACTAC
GGTCTGGACAACTTTGACACACAGTTCACCAGCGAGCCCGTGCAGCTGACCCCAGACGAT
GAGGATGCCATAAAGAGGATCGACCAGTCAGAGTTCGAAGGCTTTGAGTATATCAACCCA
TTATTGCTGTCCACCGAGGAGTCGGTGTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:9412
Chromosome Location1
LocusNot Available
References
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