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NameMBT domain-containing protein 1
SynonymsNot Available
Gene NameMBTD1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009808|MBT domain-containing protein 1
MFDGYDSCSEDTSSSSSSEESEEEVAPLPSNLPIIKNNGQVYTYPDGKSGMATCEMCGMV
GVRDAFYSKTKRFCSVSCSRSYSSNSKKASILARLQGKPPTKKAKVLQKQPLVAKLAAYA
QYQATLQNQAKTKAAVSMEGFSWGNYINSNSFIAAPVTCFKHAPMGTCWGDISENVRVEV
PNTDCSLPTKVFWIAGIVKLAGYNALLRYEGFENDSGLDFWCNICGSDIHPVGWCAASGK
PLVPPRTIQHKYTNWKAFLVKRLTGAKTLPPDFSQKVSESMQYPFKPCMRVEVVDKRHLC
RTRVAVVESVIGGRLRLVYEESEDRTDDFWCHMHSPLIHHIGWSRSIGHRFKRSDITKKQ
DGHFDTPPHLFAKVKEVDQSGEWFKEGMKLEAIDPLNLSTICVATIRKVLADGFLMIGID
GSEAADGSDWFCYHATSPSIFPVGFCEINMIELTPPRGYTKLPFKWFDYLRETGSIAAPV
KLFNKDVPNHGFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCE
SPDLYPVGWCQLTGYQLQPPASQSSRENQSASSKQKKKAKSQQYKGHKKMTTLQLKEELL
DGEDYNFLQGASDQESNGSANFYIKQEP
Number of residues628
Molecular Weight70546.805
Theoretical pINot Available
GO Classification
Functions
  • zinc ion binding
Processes
  • regulation of transcription, DNA-templated
  • embryonic skeletal system development
  • transcription, DNA-templated
  • chromatin modification
Components
  • nucleus
General FunctionZinc ion binding
Specific FunctionPutative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). Specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ05BQ5
UniProtKB Entry NameMBTD1_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0021471|MBT domain-containing protein 1 (MBTD1)
ATGTTTGACGGTTATGATAGCTGCAGTGAGGACACAAGCAGCAGCTCCAGCTCCGAAGAG
AGTGAGGAAGAAGTCGCTCCTTTACCTTCTAATCTCCCGATTATCAAAAACAATGGGCAA
GTCTACACATACCCAGATGGTAAATCTGGCATGGCTACCTGTGAGATGTGTGGGATGGTT
GGCGTCCGAGATGCTTTTTACTCTAAAACAAAGCGTTTCTGTAGCGTTTCATGTTCAAGA
AGTTACTCGTCAAACTCCAAGAAGGCAAGCATTTTGGCCAGACTTCAGGGTAAGCCTCCA
ACAAAGAAAGCAAAAGTTCTTCAGAAACAACCTTTAGTTGCTAAGCTAGCCGCATATGCT
CAGTATCAAGCTACCTTGCAAAATCAAGCAAAGACAAAAGCAGCAGTCTCCATGGAAGGT
TTCAGCTGGGGTAACTACATCAATAGCAATAGCTTTATAGCAGCTCCGGTTACCTGTTTT
AAACATGCACCTATGGGGACCTGCTGGGGTGATATCTCAGAAAATGTGAGAGTAGAAGTT
CCCAATACAGACTGCAGCCTACCTACCAAAGTCTTCTGGATTGCTGGAATTGTAAAATTA
GCAGGTTACAATGCCCTTTTAAGATATGAAGGATTTGAAAATGACTCTGGTCTGGACTTC
TGGTGCAATATATGTGGTTCTGATATCCATCCAGTTGGTTGGTGTGCAGCCAGCGGAAAA
CCTCTTGTTCCTCCTAGAACTATTCAGCATAAATATACAAACTGGAAAGCTTTTCTAGTG
AAACGACTTACTGGTGCCAAAACACTGCCTCCTGATTTCTCCCAAAAGGTTTCAGAGAGT
ATGCAGTATCCTTTCAAACCTTGCATGAGAGTAGAAGTGGTTGACAAGAGGCATTTGTGT
CGAACACGAGTAGCAGTGGTGGAAAGTGTAATTGGAGGAAGATTAAGACTAGTGTATGAA
GAAAGCGAAGATAGAACAGATGACTTCTGGTGCCATATGCACAGCCCATTAATACATCAT
ATTGGTTGGTCTCGAAGCATAGGTCATCGATTCAAAAGATCTGATATTACAAAGAAACAG
GATGGACATTTTGATACACCACCACATTTATTTGCTAAGGTAAAAGAAGTAGACCAGAGT
GGGGAATGGTTCAAGGAAGGAATGAAATTGGAAGCTATAGACCCATTAAATCTTTCTACA
ATATGTGTCGCAACCATTAGAAAGGTGCTAGCTGACGGATTCCTGATGATTGGGATCGAT
GGCTCAGAAGCAGCAGACGGATCTGACTGGTTCTGTTACCATGCAACCTCTCCTTCTATT
TTCCCTGTCGGTTTCTGTGAAATTAACATGATTGAACTTACTCCACCCAGAGGTTACACA
AAACTTCCTTTTAAATGGTTTGACTACCTCAGGGAAACTGGCTCCATTGCAGCACCAGTA
AAACTATTTAATAAGGATGTTCCAAATCACGGATTTCGTGTAGGAATGAAATTAGAAGCA
GTAGATCTCATGGAGCCACGTTTAATATGTGTAGCCACAGTAACTCGAATTATTCATCGT
CTCTTGAGGATACATTTTGATGGATGGGAAGAAGAGTATGATCAGTGGGTAGACTGTGAG
TCACCTGACCTCTATCCTGTAGGGTGGTGTCAGTTAACTGGATATCAACTACAGCCTCCA
GCATCACAGTCATCAAGAGAAAACCAATCAGCTTCATCAAAACAGAAGAAAAAGGCTAAG
TCCCAGCAATACAAAGGACATAAGAAAATGACAACACTGCAGCTGAAGGAGGAGTTGCTG
GATGGAGAGGATTATAATTTCCTTCAAGGAGCGTCTGATCAGGAAAGCAATGGCTCTGCC
AACTTCTACATCAAACAAGAGCCATGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:19866
Chromosome Location17
LocusNot Available
References
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