Tmic
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NameSodium channel subunit beta-1
SynonymsNot Available
Gene NameSCN1B
OrganismHuman
Amino acid sequence
>lcl|BSEQ0006988|Sodium channel subunit beta-1
MGRLLALVVGAALVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFR
QKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYE
CHVYRLLFFENYEHNTSVVKKIHIEVVDKANRDMASIVSEIMMYVLIVVLTIWLVAEMIY
CYKKIAAATETAAQENASEYLAITSESKENCTGVQVAE
Number of residues218
Molecular Weight24706.955
Theoretical pI4.56
GO Classification
Functions
  • voltage-gated sodium channel activity
  • sodium channel inhibitor activity
  • voltage-gated sodium channel activity involved in cardiac muscle cell action potential
  • sodium channel regulator activity
  • voltage-gated sodium channel activity involved in Purkinje myocyte action potential
Processes
  • cardiac muscle contraction
  • membrane depolarization
  • neuronal action potential propagation
  • synaptic transmission
  • membrane depolarization during cardiac muscle cell action potential
  • locomotion
  • membrane depolarization during Purkinje myocyte cell action potential
  • cardiac conduction
  • axon guidance
  • positive regulation of sodium ion transport
  • corticospinal neuron axon guidance
  • sodium ion transmembrane transport
  • regulation of atrial cardiac muscle cell membrane depolarization
  • regulation of heart rate by cardiac conduction
  • regulation of ventricular cardiac muscle cell membrane repolarization
  • cell adhesion
  • regulation of sodium ion transmembrane transporter activity
  • cardiac muscle cell action potential involved in contraction
  • positive regulation of neuron projection development
Components
  • node of Ranvier
  • voltage-gated sodium channel complex
  • intercalated disc
  • T-tubule
  • extracellular region
General FunctionVoltage-gated sodium channel activity involved in purkinje myocyte action potential
Specific FunctionCrucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.Isoform 2: Cell adhesion molecule that plays a critical role in neuronal migration and pathfinding during brain development. Stimulates neurite outgrowth.
Pfam Domain Function
Transmembrane Regions161-182
GenBank Protein ID307415
UniProtKB IDQ07699
UniProtKB Entry NameSCN1B_HUMAN
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0019451|Sodium channel subunit beta-1 (SCN1B)
ATGGGGAGGCTGCTGGCCTTAGTGGTCGGCGCGGCACTGGTGTCCTCAGCCTGCGGGGGC
TGCGTGGAGGTGGACTCGGAGACCGAGGCCGTGTATGGGATGACCTTCAAAATTCTTTGC
ATCTCCTGCAAGCGCCGCAGCGAGACCAACGCTGAGACCTTCACCGAGTGGACCTTCCGC
CAGAAGGGCACTGAGGAGTTTGTCAAGATCCTGCGCTATGAGAATGAGGTGTTGCAGCTG
GAGGAGGATGAGCGCTTCGAGGGCCGCGTGGTGTGGAATGGCAGCCGGGGCACCAAAGAC
CTGCAGGATCTGTCTATCTTCATCACCAATGTCACCTACAACCACTCGGGCGACTACGAG
TGCCACGTCTACCGCCTGCTCTTCTTCGAAAACTACGAGCACAACACCAGCGTCGTCAAG
AAGATCCACATTGAGGTAGTGGACAAAGCCAACAGAGACATGGCATCCATCGTGTCTGAG
ATCATGATGTATGTGCTCATTGTGGTGTTGACCATATGGCTCGTGGCAGAGATGATTTAC
TGCTACAAGAAGATCGCTGCCGCCACGGAGACTGCTGCACAGGAGAATGCCTCGGAATAC
CTGGCCATCACCTCTGAAAGCAAAGAGAACTGCACGGGCGTCCAGGTGGCCGAATAG
GenBank Gene IDL10338
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:10586
Chromosome Location19
Locus19q13.1
References
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  3. Makita N, Sloan-Brown K, Weghuis DO, Ropers HH, George AL Jr: Genomic organization and chromosomal assignment of the human voltage-gated Na+ channel beta 1 subunit gene (SCN1B). Genomics. 1994 Oct;23(3):628-34. 7851891
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