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NamePeroxisome proliferator-activated receptor alpha
Synonyms
  • NR1C1
  • Nuclear receptor subfamily 1 group C member 1
  • PPAR
  • PPAR-alpha
Gene NamePPARA
OrganismHuman
Amino acid sequence
>lcl|BSEQ0000142|Peroxisome proliferator-activated receptor alpha
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
Number of residues468
Molecular Weight52224.595
Theoretical pI6.2
GO Classification
Functions
  • ubiquitin conjugating enzyme binding
  • steroid hormone receptor activity
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
  • DNA binding
  • lipid binding
  • sequence-specific DNA binding
  • transcriptional activator activity, RNA polymerase II transcription factor binding
  • RNA polymerase II repressing transcription factor binding
  • transcription factor activity, sequence-specific DNA binding
  • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
  • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
  • drug binding
  • zinc ion binding
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding
Processes
  • epidermis development
  • positive regulation of fatty acid oxidation
  • behavioral response to nicotine
  • negative regulation of inflammatory response
  • regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter
  • circadian regulation of gene expression
  • negative regulation of transcription from RNA polymerase II promoter
  • cellular lipid metabolic process
  • enamel mineralization
  • negative regulation of appetite
  • lipoprotein metabolic process
  • negative regulation of pri-miRNA transcription from RNA polymerase II promoter
  • positive regulation of fatty acid beta-oxidation
  • negative regulation of cholesterol storage
  • gene expression
  • negative regulation of neuron death
  • negative regulation of macrophage derived foam cell differentiation
  • small molecule metabolic process
  • regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter
  • negative regulation of protein binding
  • response to insulin
  • transcription initiation from RNA polymerase II promoter
  • regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
  • negative regulation of blood pressure
  • positive regulation of transcription, DNA-templated
  • intracellular receptor signaling pathway
  • heart development
  • positive regulation of gluconeogenesis
  • positive regulation of transcription from RNA polymerase II promoter
  • negative regulation of transcription regulatory region DNA binding
  • fatty acid metabolic process
  • response to hypoxia
  • negative regulation of glycolytic process
  • regulation of circadian rhythm
  • wound healing
  • negative regulation of leukocyte cell-cell adhesion
  • fatty acid transport
  • lipid metabolic process
  • negative regulation of receptor biosynthetic process
  • circadian rhythm
  • negative regulation of sequestering of triglyceride
Components
  • nucleus
  • nucleoplasm
General FunctionZinc ion binding
Specific FunctionLigand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID307341
UniProtKB IDQ07869
UniProtKB Entry NamePPARA_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0021925|Peroxisome proliferator-activated receptor alpha (PPARA)
ATGGTGGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCGATCTAGAG
AGCCCGTTATCTGAAGAGTTCCTGCAAGAAATGGGAAACATCCAAGAGATTTCGCAATCC
ATCGGCGAGGATAGTTCTGGAAGCTTTGGCTTTACGGAATACCAGTATTTAGGAAGCTGT
CCTGGCTCAGATGGCTCGGTCATCACGGACACGCTTTCACCAGCTTCGAGCCCCTCCTCG
GTGACTTATCCTGTGGTCCCCGGCAGCGTGGACGAGTCTCCCAGTGGAGCATTGAACATC
GAATGTAGAATCTGCGGGGACAAGGCCTCAGGCTATCATTACGGAGTCCACGCGTGTGAA
GGCTGCAAGGGCTTCTTTCGGCGAACGATTCGACTCAAGCTGGTGTATGACAAGTGCGAC
CGCAGCTGCAAGATCCAGAAAAAGAACAGAAACAAATGCCAGTATTGTCGATTTCACAAG
TGCCTTTCTGTCGGGATGTCACACAACGCGATTCGTTTTGGACGAATGCCAAGATCTGAG
AAAGCAAAACTGAAAGCAGAAATTCTTACCTGTGAACATGACATAGAAGATTCTGAAACT
GCAGATCTCAAATCTCTGGCCAAGAGAATCTACGAGGCCTACTTGAAGAACTTCAACATG
AACAAGGTCAAAGCCCGGGTCATCCTCTCAGGAAAGGCCAGTAACAATCCACCTTTTGTC
ATACATGATATGGAGACACTGTGTATGGCTGAGAAGACGCTGGTGGCCAAGCTGGTGGCC
AATGGCATCCAGAACAAGGAGGCGGAGGTCCGCATCTTTCACTGCTGCCAGTGCACGTCA
GTGGAGACCGTCACGGAGCTCACGGAATTCGCCAAGGCCATCCCAGGCTTCGCAAACTTG
GACCTGAACGATCAAGTGACATTGCTAAAATACGGAGTTTATGAGGCCATATTCGCCATG
CTGTCTTCTGTGATGAACAAAGACGGGATGCTGGTAGCGTATGGAAATGGGTTTATAACT
CGTGAATTCCTAAAAAGCCTAAGGAAACCGTTCTGTGATATCATGGAACCCAAGTTTGAT
TTTGCCATGAAGTTCAATGCACTGGAACTGGATGACAGTGATATCTCCCTTTTTGTGGCT
GCTATCATTTGCTGTGGAGATCGTCCTGGCCTTCTAAACGTAGGACACATTGAAAAAATG
CAGGAGGGTATTGTACATGTGCTCAGACTCCACCTGCAGAGCAACCACCCGGACGATATC
TTTCTCTTCCCAAAACTTCTTCAAAAAATGGCAGACCTCCGGCAGCTGGTGACGGAGCAT
GCGCAGCTGGTGCAGATCATCAAGAAGACGGAGTCGGATGCTGCGCTGCACCCGCTACTG
CAGGAGATCTACAGGGACATGTACTGA
GenBank Gene IDL02932
GeneCard IDNot Available
GenAtlas IDPPARA
HGNC IDHGNC:9232
Chromosome Location22
Locus22q12-q13.1|22q13.31
References
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