NameADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
Synonyms
  • 3.2.2.6
  • ADP-ribosyl cyclase 2
  • Bone marrow stromal antigen 1
  • BST-1
  • cADPr hydrolase 2
  • Cyclic ADP-ribose hydrolase 2
Gene NameBST1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0002471|ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
MAAQGCAASRLLQLLLQLLLLLLLLAAGGARARWRGEGTSAHLRDIFLGRCAEYRALLSP
EQRNKNCTAIWEAFKVALDKDPCSVLPSDYDLFINLSRHSIPRDKSLFWENSHLLVNSFA
DNTRRFMPLSDVLYGRVADFLSWCRQKNDSGLDYQSCPTSEDCENNPVDSFWKRASIQYS
KDSSGVIHVMLNGSEPTGAYPIKGFFADYEIPNLQKEKITRIEIWVMHEIGGPNVESCGE
GSMKVLEKRLKDMGFQYSCINDYRPVKLLQCVDHSTHPDCALKSAAAATQRKAPSLYTEQ
RAGLIIPLFLVLASRTQL
Number of residues318
Molecular Weight35723.545
Theoretical pI7.86
GO Classification
Functions
  • NAD(P)+ nucleosidase activity
  • transferase activity
  • phosphorus-oxygen lyase activity
  • NAD+ nucleosidase activity
Processes
  • multicellular organismal development
  • positive regulation of B cell proliferation
  • humoral immune response
Components
  • anchored component of membrane
  • extrinsic component of membrane
  • plasma membrane
  • extracellular exosome
General FunctionTransferase activity
Specific FunctionSynthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID999429
UniProtKB IDQ10588
UniProtKB Entry NameBST1_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0010864|ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 (BST1)
ATGGCGGCCCAGGGGTGCGCGGCATCGCGGCTGCTCCAGCTGCTGCTGCAGCTTCTGCTT
CTACTGTTGCTGCTGGCGGCGGGCGGGGCGCGCGCGCGGTGGCGCGGGGAGGGCACCAGC
GCACACTTGCGGGACATCTTCCTGGGCCGCTGCGCCGAGTACCGCGCACTGCTGAGTCCC
GAGCAGCGGAACAAGAACTGCACAGCCATCTGGGAAGCCTTTAAAGTGGCGCTGGACAAG
GATCCCTGCTCCGTGCTGCCCTCAGACTATGACCTTTTTATTAACTTGTCCAGGCACTCT
ATTCCCAGAGATAAGTCCCTGTTCTGGGAAAATAGCCACCTCCTTGTTAACAGCTTTGCA
GACAACACCCGTCGTTTTATGCCCCTGAGCGATGTTCTGTATGGCAGGGTTGCAGATTTC
TTGAGCTGGTGTCGACAGAAAAATGACTCTGGACTCGATTACCAATCCTGCCCTACATCA
GAAGACTGTGAAAATAATCCTGTGGATTCCTTTTGGAAAAGGGCATCCATCCAGTATTCC
AAGGATAGTTCTGGGGTGATCCACGTCATGCTGAATGGTTCAGAGCCAACAGGAGCCTAT
CCCATCAAAGGTTTTTTTGCAGATTATGAAATTCCAAACCTCCAGAAGGAAAAAATTACA
CGAATCGAGATCTGGGTTATGCATGAAATTGGGGGACCCAATGTGGAATCCTGCGGGGAA
GGCAGCATGAAAGTCCTGGAAAAGAGGCTGAAGGACATGGGGTTCCAGTACAGCTGTATT
AATGATTACCGACCAGTGAAGCTCTTACAGTGCGTGGACCACAGCACCCATCCTGACTGT
GCCTTAAAGTCGGCAGCAGCCGCTACTCAAAGAAAAGCCCCAAGTCTTTATACAGAACAA
AGGGCGGGTCTTATCATTCCCCTCTTTCTGGTGCTGGCTTCCAGGACTCAACTGTAA
GenBank Gene IDD21878
GeneCard IDNot Available
GenAtlas IDBST1
HGNC IDHGNC:1118
Chromosome Location4
Locus4p15
References
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