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NameProtein tyrosine phosphatase type IVA 2
Synonyms
  • 3.1.3.48
  • HU-PP-1
  • OV-1
  • PRL-2
  • PRL2
  • Protein-tyrosine phosphatase 4a2
  • Protein-tyrosine phosphatase of regenerating liver 2
  • PTP(CAAXII)
  • PTPCAAX2
Gene NamePTP4A2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0008990|Protein tyrosine phosphatase type IVA 2
MNRPAPVEISYENMRFLITHNPTNATLNKFTEELKKYGVTTLVRVCDATYDKAPVEKEGI
HVLDWPFDDGAPPPNQIVDDWLNLLKTKFREEPGCCVAVHCVAGLGRAPVLVALALIECG
MKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFRDTNGHCCVQ
Number of residues167
Molecular Weight19127.05
Theoretical pINot Available
GO Classification
Functions
  • prenylated protein tyrosine phosphatase activity
Processes
  • peptidyl-tyrosine dephosphorylation
Components
  • nucleus
  • plasma membrane
  • extracellular exosome
  • early endosome
  • cytoplasm
General FunctionPrenylated protein tyrosine phosphatase activity
Specific FunctionProtein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ12974
UniProtKB Entry NameTP4A2_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0019697|Protein tyrosine phosphatase type IVA 2 (PTP4A2)
ATGAACCGTCCAGCCCCTGTGGAGATCTCCTATGAGAACATGCGTTTTCTGATAACTCAC
AACCCTACCAATGCTACTCTCAACAAGTTCACAGAGGAACTTAAGAAGTATGGAGTGACG
ACTTTGGTTCGAGTTTGTGATGCTACATATGATAAAGCTCCAGTTGAAAAAGAAGGAATC
CACGTTCTAGATTGGCCATTTGATGATGGAGCTCCACCCCCTAATCAGATAGTAGATGAT
TGGTTAAACCTGTTAAAAACCAAATTTCGTGAAGAGCCAGGTTGCTGTGTTGCAGTGCAT
TGTGTTGCAGGATTGGGAAGAAAAAGAAGGGGAGCGTTCAATTCCAAACAGCTGCTTTAT
TTGGAGAAATACCGACCTAAGATGCGATTACGCTTCAGAGATACCAATGGGCATTGCTGT
GTTCAGTAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:9635
Chromosome Location1
LocusNot Available
References
  1. Montagna M, Serova O, Sylla BS, Feunteun J, Lenoir GM: A 100-kb physical and transcriptional map around the EDH17B2 gene: identification of three novel genes and a pseudogene of a human homologue of the rat PRL-1 tyrosine phosphatase. Hum Genet. 1995 Nov;96(5):532-8. 8529999
  2. Cates CA, Michael RL, Stayrook KR, Harvey KA, Burke YD, Randall SK, Crowell PL, Crowell DN: Prenylation of oncogenic human PTP(CAAX) protein tyrosine phosphatases. Cancer Lett. 1996 Dec 20;110(1-2):49-55. 9018080
  3. Zhao Z, Lee CC, Monckton DG, Yazdani A, Coolbaugh MI, Li X, Bailey J, Shen Y, Caskey CT: Characterization and genomic mapping of genes and pseudogenes of a new human protein tyrosine phosphatase. Genomics. 1996 Jul 1;35(1):172-81. 8661118
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