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Transcriptional repressor NF-X1
Name | Transcriptional repressor NF-X1 |
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Synonyms |
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Gene Name | NFX1 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0009240|Transcriptional repressor NF-X1 MAEAPPVSGTFKFNTDAAEFIPQEKKNSGLNCGTQRRLDSNRIGRRNYSSPPPCHLSRQV PYDEISAVHQHSYHPSGSKPKSQQTSFQSSPCNKSPKSHGLQNQPWQKLRNEKHHIRVKK AQSLAEQTSDTAGLESSTRSESGTDLREHSPSESEKEVVGADPRGAKPKKATQFVYSYGR GPKVKGKLKCEWSNRTTPKPEDAGPESTKPVGVFHPDSSEASSRKGVLDGYGARRNEQRR YPQKRPPWEVEGARPRPGRNPPKQEGHRHTNAGHRNNMGPIPKDDLNERPAKSTCDSENL AVINKSSRRVDQEKCTVRRQDPQVVSPFSRGKQNHVLKNVETHTGSLIEQLTTEKYECMV CCELVRVTAPVWSCQSCYHVFHLNCIKKWARSPASQADGQSGWRCPACQNVSAHVPNTYT CFCGKVKNPEWSRNEIPHSCGEVCRKKQPGQDCPHSCNLLCHPGPCPPCPAFMTKTCECG RTRHTVRCGQAVSVHCSNPCENILNCGQHQCAELCHGGQCQPCQIILNQVCYCGSTSRDV LCGTDVGKSDGFGDFSCLKICGKDLKCGNHTCSQVCHPQPCQQCPRLPQLVRCCPCGQTP LSQLLELGSSSRKTCMDPVPSCGKVCGKPLPCGSLDFIHTCEKLCHEGDCGPCSRTSVIS CRCSFRTKELPCTSLKSEDATFMCDKRCNKKRLCGRHKCNEICCVDKEHKCPLICGRKLR CGLHRCEEPCHRGNCQTCWQASFDELTCHCGASVIYPPVPCGTRPPECTQTCARVHECDH PVYHSCHSEEKCPPCTFLTQKWCMGKHEFRSNIPCHLVDISCGLPCSATLPCGMHKCQRL CHKGECLVDEPCKQPCTTPRADCGHPCMAPCHTSSPCPVTACKAKVELQCECGRRKEMVI CSEASSTYQRIAAISMASKITDMQLGGSVEISKLITKKEVHQARLECDEECSALERKKRL AEAFHISEDSDPFNIRSSGSKFSDSLKEDARKDLKFVSDVEKEMETLVEAVNKGKNSKKS HSFPPMNRDHRRIIHDLAQVYGLESVSYDSEPKRNVVVTAIRGKSVCPPTTLTGVLEREM QARPPPPIPHHRHQSDKNPGSSNLQKITKEPIIDYFDVQD |
Number of residues | 1120 |
Molecular Weight | 124393.645 |
Theoretical pI | Not Available |
GO Classification | Functions
Processes
Components
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General Function | Zinc ion binding |
Specific Function | Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination. |
Pfam Domain Function | |
Transmembrane Regions | Not Available |
GenBank Protein ID | Not Available |
UniProtKB ID | Q12986 |
UniProtKB Entry Name | NFX1_HUMAN |
Cellular Location | Nucleus |
Gene sequence | >lcl|BSEQ0020865|Transcriptional repressor NF-X1 (NFX1) ATGGCGGAGGCGCCTCCTGTCTCAGGTACTTTTAAATTCAATACAGATGCTGCTGAATTC ATTCCTCAGGAGAAAAAAAATTCTGGTCTAAATTGTGGGACTCAAAGGAGACTAGACTCT AATAGGATTGGTAGAAGAAATTACAGTTCACCACCTCCCTGTCACCTTTCCAGGCAGGTC CCTTATGATGAAATCTCTGCTGTTCATCAGCATAGTTATCATCCGTCAGGAAGCAAACCT AAGAGTCAGCAGACGTCTTTCCAGTCCTCTCCTTGTAATAAATCGCCCAAGAGCCATGGC CTTCAGAATCAACCTTGGCAGAAATTGAGGAATGAGAAGCACCATATCAGAGTCAAGAAA GCACAGAGTCTTGCTGAGCAGACCTCAGATACAGCTGGATTAGAGAGCTCGACCAGATCA GAGAGTGGGACAGACCTCAGAGAGCATAGTCCTTCTGAGAGTGAGAAGGAAGTTGTGGGT GCAGATCCCAGGGGAGCAAAACCCAAAAAAGCAACACAGTTTGTATACAGCTATGGTAGA GGACCAAAAGTCAAGGGGAAACTCAAATGTGAATGGAGTAACCGAACAACTCCAAAACCG GAGGATGCTGGACCCGAAAGTACCAAACCTGTGGGGGTTTTCCACCCTGACTCTTCAGAG GCATCCTCTAGAAAAGGAGTATTGGATGGGTATGGAGCCAGACGAAATGAGCAGAGAAGA TACCCACAGAAAAGGCCTCCCTGGGAAGTGGAGGGGGCCAGGCCACGACCAGGCAGAAAT CCACCAAAACAGGAGGGCCACCGACATACAAACGCAGGACACAGAAACAACATGGGCCCC ATTCCAAAGGATGACCTCAATGAAAGACCAGCAAAATCTACCTGTGACAGTGAGAACTTG GCAGTCATCAACAAGTCTTCCAGGAGGGTTGACCAAGAGAAATGCACTGTACGGAGGCAG GATCCTCAAGTAGTATCTCCTTTCTCCCGAGGCAAACAGAACCATGTGCTAAAGAATGTG GAAACGCACACAGGTTCTCTAATTGAACAACTAACAACAGAAAAATACGAGTGCATGGTG TGCTGTGAATTGGTTCGTGTCACGGCCCCAGTGTGGAGTTGTCAGAGCTGTTACCATGTG TTTCATTTGAACTGCATAAAGAAATGGGCAAGGTCTCCAGCATCTCAAGCAGATGGCCAG AGTGGTTGGAGGTGCCCTGCCTGTCAGAATGTTTCTGCACATGTTCCTAATACCTACACT TGTTTCTGTGGCAAGGTAAAGAATCCTGAGTGGAGCAGAAATGAAATTCCACATAGCTGT GGTGAGGTTTGTAGAAAGAAACAGCCTGGCCAGGACTGCCCACATTCCTGTAACCTTCTC TGCCATCCAGGACCCTGCCCACCCTGCCCTGCCTTTATGACAAAAACATGTGAATGTGGA CGAACCAGGCACACAGTTCGCTGTGGTCAGGCTGTCTCAGTCCACTGTTCTAACCCATGT GAGAATATTTTGAACTGTGGTCAGCACCAGTGTGCTGAGCTGTGCCATGGGGGTCAGTGC CAGCCTTGCCAGATCATTTTGAACCAGGTATGCTATTGCGGCAGCACCTCCCGAGATGTG TTATGTGGAACCGATGTAGGAAAGTCTGATGGATTTGGGGATTTCAGCTGTTTAAAGATA TGTGGCAAGGACTTGAAATGCGGTAACCATACATGTTCGCAAGTGTGCCACCCTCAGCCC TGCCAGCAATGCCCACGGCTCCCCCAGCTGGTGCGCTGTTGCCCCTGTGGCCAAACTCCT CTCAGCCAATTGCTAGAACTTGGAAGTAGTAGTCGGAAAACATGCATGGACCCTGTGCCT TCATGTGGAAAAGTGTGCGGCAAGCCTCTGCCTTGTGGTTCCTTAGATTTCATTCATACC TGTGAAAAGCTCTGCCATGAAGGAGACTGTGGACCATGCTCTCGCACATCAGTTATTTCC TGCAGATGCTCTTTCAGAACAAAGGAGCTTCCATGTACCAGTCTCAAAAGTGAAGATGCT ACATTTATGTGTGACAAGCGGTGTAACAAGAAACGGTTGTGTGGACGGCATAAATGTAAT GAGATATGCTGTGTGGATAAGGAGCACAAGTGTCCTTTGATTTGTGGGAGGAAACTCCGT TGTGGCCTTCATAGGTGTGAAGAACCTTGTCATCGTGGAAACTGCCAGACATGCTGGCAA GCCAGTTTTGATGAATTAACCTGCCATTGTGGTGCATCAGTGATTTACCCTCCAGTTCCC TGTGGTACTAGGCCCCCTGAATGTACCCAAACCTGCGCTAGAGTCCATGAGTGTGACCAT CCAGTATATCATTCTTGTCATAGTGAGGAGAAGTGTCCCCCTTGCACTTTCCTAACTCAG AAGTGGTGCATGGGCAAGCATGAGTTTCGGAGCAACATCCCCTGTCACCTGGTTGATATC TCTTGCGGATTACCCTGCAGTGCCACGCTACCATGTGGGATGCACAAATGTCAGAGACTC TGTCACAAAGGGGAGTGTCTTGTGGATGAGCCCTGCAAGCAGCCCTGCACCACCCCCAGA GCTGACTGTGGTCACCCGTGTATGGCACCCTGCCATACCAGCTCACCCTGCCCTGTGACT GCTTGTAAAGCTAAGGTAGAGCTACAGTGTGAATGTGGACGAAGAAAAGAGATGGTGATT TGCTCTGAAGCATCTAGTACTTATCAAAGAATAGCTGCAATCTCCATGGCCTCTAAGATA ACAGACATGCAGCTTGGAGGTTCAGTGGAGATCAGCAAGTTAATTACCAAAAAGGAAGTT CATCAAGCCAGGCTGGAGTGTGATGAGGAGTGTTCAGCCTTGGAAAGGAAAAAGAGATTA GCAGAGGCATTTCATATCAGTGAGGATTCTGATCCTTTCAATATACGTTCTTCAGGGTCA AAATTCAGTGATAGTTTGAAAGAAGATGCCAGGAAGGACTTAAAGTTTGTCAGTGACGTT GAGAAGGAAATGGAAACCCTCGTGGAGGCCGTGAATAAGGGAAAGAATAGTAAGAAAAGC CACAGCTTCCCTCCCATGAACAGAGACCACCGCCGGATCATCCATGACTTGGCCCAAGTT TATGGCCTGGAGAGCGTGAGCTATGACAGTGAACCGAAGCGCAATGTGGTGGTCACTGCC ATCAGGGGGAAGTCCGTTTGTCCTCCTACCACGCTGACAGGTGTGCTTGAAAGGGAAATG CAGGCACGGCCTCCACCACCGATTCCTCATCACAGACATCAGTCAGACAAGAATCCTGGG AGCAGTAATTTACAGAAAATAACCAAGGAGCCAATAATTGACTATTTTGACGTCCAGGAC TAA |
GenBank Gene ID | Not Available |
GeneCard ID | Not Available |
GenAtlas ID | Not Available |
HGNC ID | HGNC:7803 |
Chromosome Location | 9 |
Locus | Not Available |
References |
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