NameAquaporin-6
Synonyms
  • AQP-6
  • AQP2L
  • Aquaporin-2-like
  • hKID
  • Kidney-specific aquaporin
Gene NameAQP6
OrganismHuman
Amino acid sequence
>lcl|BSEQ0019653|Aquaporin-6
MDAVEPGGRGWASMLACRLWKAISRALFAEFLATGLYVFFGVGSVMRWPTALPSVLQIAI
TFNLVTAMAVQVTWKASGAHANPAVTLAFLVGSHISLPRAVAYVAAQLVGATVGAALLYG
VMPGDIRETLGINVVRNSVSTGQAVAVELLLTLQLVLCVFASTDSRQTSGSPATMIGISV
ALGHLIGIHFTGCSMNPARSFGPAIIIGKFTVHWVFWVGPLMGALLASLIYNFVLFPDTK
TLAQRLAILTGTVEVGTGAGAGAEPLKKESQPGSGAVEMESV
Number of residues282
Molecular Weight29370.215
Theoretical pINot Available
GO Classification
Functions
  • glycerol channel activity
  • water channel activity
  • nitrate transmembrane transporter activity
  • anion channel activity
Processes
  • cellular water homeostasis
  • glycerol transport
  • transport
  • anion transmembrane transport
  • transmembrane transport
  • excretion
  • water transport
  • odontogenesis
Components
  • integral component of plasma membrane
  • apical plasma membrane
  • transport vesicle membrane
General FunctionWater channel activity
Specific FunctionForms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism.
Pfam Domain Function
Transmembrane Regions31-48 55-73 100-121 142-162 169-188 215-236
GenBank Protein IDNot Available
UniProtKB IDQ13520
UniProtKB Entry NameAQP6_HUMAN
Cellular LocationCytoplasmic vesicle membrane
Gene sequence
>lcl|BSEQ0019654|Aquaporin-6 (AQP6)
ATGGATGCAGTGGAGCCAGGGGGACGTGGCTGGGCCAGCATGTTGGCGTGCAGGCTTTGG
AAAGCCATCAGCAGGGCGCTGTTTGCAGAGTTCCTGGCCACGGGGCTGTATGTGTTCTTT
GGCGTGGGCTCAGTCATGCGCTGGCCCACAGCACTTCCCTCCGTGCTACAGATTGCCATC
ACCTTCAACCTGGTCACCGCCATGGCTGTGCAGGTCACCTGGAAGGCCAGCGGGGCCCAC
GCCAACCCCGCCGTGACGCTGGCCTTCCTCGTAGGCTCCCACATCTCTCTGCCCCGTGCT
GTGGCCTATGTGGCTGCCCAGCTGGTGGGGGCCACGGTGGGGGCTGCTCTGCTTTATGGG
GTCATGCCGGGAGACATCCGAGAGACCCTTGGGATCAACGTGGTCCGGAACAGTGTCTCA
ACTGGCCAGGCGGTGGCAGTGGAGCTGCTTCTGACCCTGCAGCTGGTGCTCTGTGTCTTC
GCTTCCACCGACAGCCGTCAGACATCAGGCTCCCCGGCCACCATGATTGGGATCTCTGTG
GCACTGGGCCACCTCATTGGGATCCACTTCACTGGCTGCTCCATGAATCCAGCCCGCTCC
TTCGGCCCTGCCATCATCATTGGGAAGTTCACAGTCCACTGGGTCTTCTGGGTGGGGCCC
CTGATGGGAGCCCTCCTGGCCTCACTGATCTACAACTTCGTCCTGTTCCCCGACACCAAG
ACCCTGGCGCAGCGGCTGGCTATCCTCACAGGCACCGTAGAGGTGGGGACAGGGGCAGGG
GCAGGGGCGGAGCCCCTGAAGAAGGAATCCCAGCCGGGTTCGGGAGCCGTGGAGATGGAG
AGTGTGTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:639
Chromosome Location12
LocusNot Available
References
  1. Ma T, Yang B, Kuo WL, Verkman AS: cDNA cloning and gene structure of a novel water channel expressed exclusively in human kidney: evidence for a gene cluster of aquaporins at chromosome locus 12q13. Genomics. 1996 Aug 1;35(3):543-50. 8812490
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