Histone deacetylase 1

NameHistone deacetylase 1
Synonyms
  • 3.5.1.98
  • HD1
  • RPD3L1
Gene NameHDAC1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0011697|Histone deacetylase 1
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
Number of residues482
Molecular Weight55102.615
Theoretical pI5.16
GO Classification
Functions
  • NF-kappaB binding
  • protein deacetylase activity
  • repressing transcription factor binding
  • RNA polymerase II repressing transcription factor binding
  • transcription regulatory region DNA binding
  • transcription regulatory region sequence-specific DNA binding
  • transcription factor binding
  • histone deacetylase activity
  • enzyme binding
  • transcription factor activity, sequence-specific DNA binding
  • protein N-terminus binding
  • activating transcription factor binding
  • RNA polymerase II transcription corepressor activity
  • core promoter binding
  • deacetylase activity
  • histone deacetylase binding
  • NAD-dependent histone deacetylase activity (H3-K14 specific)
Processes
  • negative regulation of transcription from RNA polymerase II promoter
  • blood coagulation
  • regulation of gene expression, epigenetic
  • chromatin remodeling
  • mitotic cell cycle
  • epidermal cell differentiation
  • odontogenesis of dentin-containing tooth
  • eyelid development in camera-type eye
  • transcription, DNA-templated
  • embryonic digit morphogenesis
  • histone H3 deacetylation
  • transforming growth factor beta receptor signaling pathway
  • ATP-dependent chromatin remodeling
  • fungiform papilla formation
  • histone H4 deacetylation
  • negative regulation of gene expression
  • histone deacetylation
  • hair follicle placode formation
  • negative regulation by host of viral transcription
  • chromatin organization
  • negative regulation of androgen receptor signaling pathway
  • gene expression
  • positive regulation of receptor biosynthetic process
  • Notch signaling pathway
  • transcription initiation from RNA polymerase II promoter
  • protein deacetylation
  • negative regulation of transcription, DNA-templated
  • viral process
  • positive regulation of transcription, DNA-templated
  • negative regulation of cell cycle
  • negative regulation of apoptotic process
  • circadian regulation of gene expression
  • neurotrophin TRK receptor signaling pathway
  • positive regulation of transcription from RNA polymerase II promoter
  • chromatin modification
  • positive regulation of cell proliferation
  • negative regulation of gene expression, epigenetic
Components
  • nucleus
  • chromatin
  • nuclear chromatin
  • NuRD complex
  • Sin3 complex
  • cytosol
  • histone deacetylase complex
  • nucleoplasm
  • cytoplasm
  • protein complex
General FunctionTranscription regulatory region sequence-specific dna binding
Specific FunctionResponsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID1277084
UniProtKB IDQ13547
UniProtKB Entry NameHDAC1_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0011698|Histone deacetylase 1 (HDAC1)
ATGGCGCAGACGCAGGGCACCCGGAGGAAAGTCTGTTACTACTACGACGGGGATGTTGGA
AATTACTATTATGGACAAGGCCACCCAATGAAGCCTCACCGAATCCGCATGACTCATAAT
TTGCTGCTCAACTATGGTCTCTACCGAAAAATGGAAATCTATCGCCCTCACAAAGCCAAT
GCTGAGGAGATGACCAAGTACCACAGCGATGACTACATTAAATTCTTGCGCTCCATCCGT
CCAGATAACATGTCGGAGTACAGCAAGCAGATGCAGAGATTCAACGTTGGTGAGGACTGT
CCAGTATTCGATGGCCTGTTTGAGTTCTGTCAGTTGTCTACTGGTGGTTCTGTGGCAAGT
GCTGTGAAACTTAATAAGCAGCAGACGGACATCGCTGTGAATTGGGCTGGGGGCCTGCAC
CATGCAAAGAAGTCCGAGGCATCTGGCTTCTGTTACGTCAATGATATCGTCTTGGCCATC
CTGGAACTGCTAAAGTATCACCAGAGGGTGCTGTACATTGACATTGATATTCACCATGGT
GACGGCGTGGAAGAGGCCTTCTACACCACGGACCGGGTCATGACTGTGTCCTTTCATAAG
TATGGAGAGTACTTCCCAGGAACTGGGGACCTACGGGATATCGGGGCTGGCAAAGGCAAG
TATTATGCTGTTAACTACCCGCTCCGAGACGGGATTGATGACGAGTCCTATGAGGCCATT
TTCAAGCCGGTCATGTCCAAAGTAATGGAGATGTTCCAGCCTAGTGCGGTGGTCTTACAG
TGTGGCTCAGACTCCCTATCTGGGGATCGGTTAGGTTGCTTCAATCTAACTATCAAAGGA
CACGCCAAGTGTGTGGAATTTGTCAAGAGCTTTAACCTGCCTATGCTGATGCTGGGAGGC
GGTGGTTACACCATTCGTAACGTTGCCCGGTGCTGGACATATGAGACAGCTGTGGCCCTG
GATACGGAGATCCCTAATGAGCTTCCATACAATGACTACTTTGAATACTTTGGACCAGAT
TTCAAGCTCCACATCAGTCCTTCCAATATGACTAACCAGAACACGAATGAGTACCTGGAG
AAGATCAAACAGCGACTGTTTGAGAACCTTAGAATGCTGCCGCACGCACCTGGGGTCCAA
ATGCAGGCGATTCCTGAGGACGCCATCCCTGAGGAGAGTGGCGATGAGGACGAAGACGAC
CCTGACAAGCGCATCTCGATCTGCTCCTCTGACAAACGAATTGCCTGTGAGGAAGAGTTC
TCCGATTCTGAAGAGGAGGGAGAGGGGGGCCGCAAGAACTCTTCCAACTTCAAAAAAGCC
AAGAGAGTCAAAACAGAGGATGAAAAAGAGAAAGACCCAGAGGAGAAGAAAGAAGTCACC
GAAGAGGAGAAAACCAAGGAGGAGAAGCCAGAAGCCAAAGGGGTCAAGGAGGAGGTCAAG
TTGGCCTGA
GenBank Gene IDU50079
GeneCard IDNot Available
GenAtlas IDHDAC1
HGNC IDHGNC:4852
Chromosome Location1
Locus1p34
References
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