NameKrueppel-like factor 5
Synonyms
  • Basic transcription element-binding protein 2
  • BTE-binding protein 2
  • BTEB2
  • CKLF
  • Colon krueppel-like factor
  • GC-box-binding protein 2
  • IKLF
  • Intestinal-enriched krueppel-like factor
  • Transcription factor BTEB2
Gene NameKLF5
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009811|Krueppel-like factor 5
MATRVLSMSARLGPVPQPPAPQDEPVFAQLKPVLGAANPARDAALFPGEELKHAHHRPQA
QPAPAQAPQPAQPPATGPRLPPEDLVQTRCEMEKYLTPQLPPVPIIPEHKKYRRDSASVV
DQFFTDTEGLPYSINMNVFLPDITHLRTGLYKSQRPCVTHIKTEPVAIFSHQSETTAPPP
APTQALPEFTSIFSSHQTAAPEVNNIFIKQELPTPDLHLSVPTQQGHLYQLLNTPDLDMP
SSTNQTAAMDTLNVSMSAAMAGLNTHTSAVPQTAVKQFQGMPPCTYTMPSQFLPQQATYF
PPSPPSSEPGSPDRQAEMLQNLTPPPSYAATIASKLAIHNPNLPTTLPVNSQNIQPVRYN
RRSNPDLEKRRIHYCDYPGCTKVYTKSSHLKAHLRTHTGEKPYKCTWEGCDWRFARSDEL
TRHYRKHTGAKPFQCGVCNRSFSRSDHLALHMKRHQN
Number of residues457
Molecular Weight50791.25
Theoretical pINot Available
GO Classification
Functions
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
  • metal ion binding
Processes
  • positive regulation of fat cell differentiation
  • microvillus assembly
  • regulation of microvillus assembly
  • skeletal muscle cell differentiation
  • intestinal epithelial cell development
  • transcription from RNA polymerase II promoter
  • positive regulation of transcription from RNA polymerase II promoter
  • negative regulation of transcription from RNA polymerase II promoter
  • angiogenesis
Components
  • cytoplasm
  • plasma membrane
  • Golgi apparatus
  • nucleoplasm
  • intracellular membrane-bounded organelle
General FunctionTranscriptional activator activity, rna polymerase ii core promoter proximal region sequence-specific binding
Specific FunctionTranscription factor that binds to GC box promoter elements. Activates the transcription of these genes.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ13887
UniProtKB Entry NameKLF5_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0020902|Krueppel-like factor 5 (KLF5)
ATGGAGAAGTATCTGACACCTCAGCTTCCTCCAGTTCCTATAATTCCAGAGCATAAAAAG
TATAGACGAGACAGTGCCTCAGTCGTAGACCAGTTCTTCACTGACACTGAAGGGTTACCT
TACAGTATCAACATGAACGTCTTCCTCCCTGACATCACTCACCTGAGAACTGGCCTCTAC
AAATCCCAGAGACCGTGCGTAACACACATCAAGACAGAACCTGTTGCCATTTTCAGCCAC
CAGAGTGAAACGACTGCCCCTCCTCCGGCCCCGACCCAGGCCCTCCCTGAGTTCACCAGT
ATATTCAGCTCACACCAGACCGCAGCTCCAGAGGTGAACAATATTTTCATCAAACAAGAA
CTTCCTACACCAGATCTTCATCTTTCTGTCCCTACCCAGCAGGGCCACCTGTACCAGCTA
CTGAATACACCGGATCTAGATATGCCCAGTTCTACAAATCAGACAGCAGCAATGGACACT
CTTAATGTTTCTATGTCAGCTGCCATGGCAGGCCTTAACACACACACCTCTGCTGTTCCG
CAGACTGCAGTGAAACAATTCCAGGGCATGCCCCCTTGCACATACACAATGCCAAGTCAG
TTTCTTCCACAACAGGCCACTTACTTTCCCCCGTCACCACCAAGCTCAGAGCCTGGAAGT
CCAGATAGACAAGCAGAGATGCTCCAGAATTTAACCCCACCTCCATCCTATGCTGCTACA
ATTGCTTCTAAACTGGCAATTCACAATCCAAATTTACCCACCACCCTGCCAGTTAACTCA
CAAAACATCCAACCTGTCAGATACAATAGAAGGAGTAACCCCGATTTGGAGAAACGACGC
ATCCACTACTGCGATTACCCTGGTTGCACAAAAGTTTATACCAAGTCTTCTCATTTAAAA
GCTCACCTGAGGACTCACACTGGTGAAAAGCCATACAAGTGTACCTGGGAAGGCTGCGAC
TGGAGGTTCGCGCGATCGGATGAGCTGACCCGCCACTACCGGAAGCACACAGGCGCCAAG
CCCTTCCAGTGCGGGGTGTGCAACCGCAGCTTCTCGCGCTCTGACCACCTGGCCCTGCAT
ATGAAGAGGCACCAGAACTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:6349
Chromosome Location13
LocusNot Available
References
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  2. Camacho-Vanegas O, Till J, Miranda-Lorenzo I, Ozturk B, Camacho SC, Martignetti JA: Shaking the family tree: identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors. FASEB J. 2013 Feb;27(2):432-6. doi: 10.1096/fj.12-220319. Epub 2012 Nov 7. 23134681
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