You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on Toxin, Toxin Target Database.
NameMetabotropic glutamate receptor 2
Synonyms
  • GPRC1B
  • MGLUR2
Gene NameGRM2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0010682|Metabotropic glutamate receptor 2
MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQ
RLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHI
CPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY
FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK
VGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGAL
ESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQR
DCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYK
DFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTL
DTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADC
GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKA
SGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARI
FGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLR
CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF
YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAA
RASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
Number of residues872
Molecular Weight95566.715
Theoretical pI8.16
GO Classification
Functions
  • G-protein coupled receptor activity
  • glutamate receptor activity
  • calcium channel regulator activity
  • group II metabotropic glutamate receptor activity
Processes
  • synaptic transmission
  • glutamate secretion
  • negative regulation of adenylate cyclase activity
  • regulation of synaptic transmission, glutamatergic
  • G-protein coupled glutamate receptor signaling pathway
Components
  • intracellular
  • plasma membrane
  • cell junction
  • integral component of plasma membrane
  • dendrite
  • presynaptic membrane
  • axon
General FunctionGroup ii metabotropic glutamate receptor activity
Specific FunctionG-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.
Pfam Domain Function
Transmembrane Regions568-590 605-625 637-655 680-700 726-747 761-783 794-819
GenBank Protein ID999416
UniProtKB IDQ14416
UniProtKB Entry NameGRM2_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0010683|Metabotropic glutamate receptor 2 (GRM2)
ATGGGATCGCTGCTTGCGCTCCTGGCACTGCTGCTGCTGTGGGGTGCTGTGGCTGAGGGC
CCAGCCAAGAAGGTGCTGACCCTGGAGGGAGACTTGGTGCTGGGTGGGCTGTTCCCAGTG
CACCAGAAGGGCGGCCCAGCAGAGGACTGTGGTCCTGTCAATGAGCACCGTGGCATCCAG
CGCCTGGAGGCCATGCTTTTTGCACTGGACCGCATCAACCGTGACCCGCACCTGCTGCCT
GGCGTGCGCCTGGGTGCACACATCCTCGACAGTTGCTCCAAGGACACACATGCGCTGGAG
CAGGCACTGGACTTTGTGCGTGCCTCACTCAGCCGTGGTGCTGATGGCTCACGCCACATC
TGCCCCGACGGCTCTTATGCGACCCATGGTGATGCTCCCACTGCCATCACTGGTGTTATT
GGCGGTTCCTACAGTGATGTCTCCATCCAGGTGGCCAACCTCTTGAGGCTATTTCAGATC
CCACAGATTAGCTACGCCTCTACCAGTGCCAAGCTGAGTGACAAGTCCCGCTATGACTAC
TTTGCCCGCACAGTGCCTCCTGACTTCTTCCAAGCCAAGGCCATGGCTGAGATTCTCCGC
TTCTTCAACTGGACCTATGTGTCCACTGTGGCGTCTGAGGGCGACTATGGCGAGACAGGC
ATTGAGGCCTTTGAGCTAGAGGCTCGTGCCCGCAACATCTGTGTGGCCACCTCGGAGAAA
GTGGGCCGTGCCATGAGCCGCGCGGCCTTTGAGGGTGTGGTGCGAGCCCTGCTGCAGAAG
CCCAGTGCCCGCGTGGCTGTCCTGTTCACCCGTTCTGAGGATGCCCGGGAGCTGCTTGCT
GCCAGCCAGCGCCTCAATGCCAGCTTCACCTGGGTGGCCAGTGATGGTTGGGGGGCCCTG
GAGAGTGTGGTGGCAGGCAGTGAGGGGGCTGCTGAGGGTGCTATCACCATCGAGCTGGCC
TCCTACCCCATCAGTGACTTTGCCTCCTACTTCCAGAGCCTGGACCCTTGGAACAACAGC
CGGAACCCCTGGTTCCGTGAATTCTGGGAGCAGAGGTTCCGCTGCAGCTTCCGGCAGCGA
GACTGCGCAGCCCACTCTCTCCGGGCTGTGCCCTTTGAGCAGGAGTCCAAGATCATGTTT
GTGGTCAATGCAGTGTACGCCATGGCCCATGCGCTCCACAACATGCACCGTGCCCTCTGC
CCCAACACCACCCGGCTCTGTGACGCGATGCGGCCAGTTAACGGGCGCCGCCTCTACAAG
GACTTTGTGCTCAACGTCAAGTTTGATGCCCCCTTTCGCCCAGCTGACACCCACAATGAG
GTCCGCTTTGACCGCTTTGGTGATGGTATTGGCCGCTACAACATCTTCACCTATCTGCGT
GCAGGCAGTGGGCGCTATCGCTACCAGAAGGTGGGCTACTGGGCAGAAGGCTTGACTCTG
GACACCAGCCTCATCCCATGGGCCTCACCCTCAGCCGGCCCCCTGCCCGCCTCTCGCTGC
AGTGAGCCCTGCCTCCAGAATGAGGTGAAGAGTGTGCAGCCGGGCGAAGTCTGCTGCTGG
CTCTGCATTCCGTGCCAGCCCTATGAGTACCGATTGGACGAATTCACTTGCGCTGATTGT
GGCCTGGGCTACTGGCCCAATGCCAGCCTGACTGGCTGCTTCGAACTGCCCCAGGAGTAC
ATCCGCTGGGGCGATGCCTGGGCTGTGGGACCTGTCACCATCGCCTGCCTCGGTGCCCTG
GCCACCCTCTTTGTGCTGGGTGTCTTTGTGCGGCACAATGCCACACCAGTGGTCAAGGCC
TCAGGTCGGGAGCTCTGCTACATCCTGCTGGGTGGTGTCTTCCTCTGCTACTGCATGACC
TTCATCTTCATTGCCAAGCCATCCACGGCAGTGTGTACCTTACGGCGTCTTGGTTTGGGC
ACTGCCTTCTCTGTCTGCTACTCAGCCCTGCTCACCAAGACCAACCGCATTGCACGCATC
TTCGGTGGGGCCCGGGAGGGTGCCCAGCGGCCACGCTTCATCAGTCCTGCCTCACAGGTG
GCCATCTGCCTGGCACTTATCTCGGGCCAGCTGCTCATCGTGGTCGCCTGGCTGGTGGTG
GAGGCACCGGGCACAGGCAAGGAGACAGCCCCCGAACGGCGGGAGGTGGTGACACTGCGC
TGCAACCACCGCGATGCAAGTATGTTGGGCTCGCTGGCCTACAATGTGCTCCTCATCGCG
CTCTGCACGCTTTATGCCTTCAAGACTCGCAAGTGCCCCGAAAACTTCAACGAGGCCAAG
TTCATTGGCTTCACCATGTACACCACCTGCATCATCTGGCTGGCATTCCTGCCCATCTTC
TATGTCACCTCCAGTGACTACCGGGTACAGACCACCACCATGTGCGTGTCAGTCAGCCTC
AGCGGCTCCGTGGTGCTTGGCTGCCTCTTTGCGCCCAAGCTGCACATCATCCTCTTCCAG
CCGCAGAAGAACGTGGTTAGCCACCGGGCACCCACCAGCCGCTTTGGCAGTGCTGCTGCC
AGGGCCAGCTCCAGCCTTGGCCAAGGGTCTGGCTCCCAGTTTGTCCCCACTGTTTGCAAT
GGCCGTGAGGTGGTGGACTCGACAACGTCATCGCTTTGA
GenBank Gene IDL35318
GeneCard IDNot Available
GenAtlas IDGRM2
HGNC IDHGNC:4594
Chromosome Location3
Locus3p21.1
References
  1. Flor PJ, Lindauer K, Puttner I, Ruegg D, Lukic S, Knopfel T, Kuhn R: Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 2. Eur J Neurosci. 1995 Apr 1;7(4):622-9. 7620613
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. 15489334
  3. Gonzalez-Maeso J, Ang RL, Yuen T, Chan P, Weisstaub NV, Lopez-Gimenez JF, Zhou M, Okawa Y, Callado LF, Milligan G, Gingrich JA, Filizola M, Meana JJ, Sealfon SC: Identification of a serotonin/glutamate receptor complex implicated in psychosis. Nature. 2008 Mar 6;452(7183):93-7. doi: 10.1038/nature06612. Epub 2008 Feb 24. 18297054
  4. Moreno JL, Muguruza C, Umali A, Mortillo S, Holloway T, Pilar-Cuellar F, Mocci G, Seto J, Callado LF, Neve RL, Milligan G, Sealfon SC, Lopez-Gimenez JF, Meana JJ, Benson DL, Gonzalez-Maeso J: Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A.mGlu2) receptor heteromerization and its psychoactive behavioral function. J Biol Chem. 2012 Dec 28;287(53):44301-19. doi: 10.1074/jbc.M112.413161. Epub 2012 Nov 5. 23129762
  5. Delille HK, Becker JM, Burkhardt S, Bleher B, Terstappen GC, Schmidt M, Meyer AH, Unger L, Marek GJ, Mezler M: Heterocomplex formation of 5-HT2A-mGlu2 and its relevance for cellular signaling cascades. Neuropharmacology. 2012 Jun;62(7):2184-91. doi: 10.1016/j.neuropharm.2012.01.010. Epub 2012 Jan 25. 22300836