NameHydroxyacylglutathione hydrolase, mitochondrial
Synonyms
  • 3.1.2.6
  • GLO2
  • Glx II
  • Glyoxalase II
  • HAGH1
Gene NameHAGH
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037149|Hydroxyacylglutathione hydrolase, mitochondrial
MVVGRGLLGRRSLAALGAACARRGLGPALLGVFCHTDLRKNLTVDEGTMKVEVLPALTDN
YMYLVIDDETKEAAIVDPVQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESG
LKVYGGDDRIGALTHKITHLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFT
GDTLFVAGCGKFYEGTADEMCKALLEVLGRLPPDTRVYCGHEYTINNLKFARHVEPGNAA
IREKLAWAKEKYSIGEPTVPSTLAEEFTYNPFMRVREKTVQQHAGETDPVTTMRAVRREK
DQFKMPRD
Number of residues308
Molecular Weight33805.645
Theoretical pI7.36
GO Classification
Functions
  • hydroxyacylglutathione hydrolase activity
  • metal ion binding
Processes
  • methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione
  • small molecule metabolic process
  • carbohydrate metabolic process
  • cellular metabolic process
  • pyruvate metabolic process
  • glutathione biosynthetic process
Components
  • cytoplasm
  • mitochondrial matrix
  • cytosol
  • extracellular exosome
General FunctionMetal ion binding
Specific FunctionThiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID1237213
UniProtKB IDQ16775
UniProtKB Entry NameGLO2_HUMAN
Cellular LocationMitochondrion matrix
Gene sequence
>lcl|BSEQ0019185|Hydroxyacylglutathione hydrolase, mitochondrial (HAGH)
ATGAAGGTAGAGGTGCTGCCTGCCCTGACCGACAACTACATGTACCTGGTCATTGATGAT
GAGACCAAGGAGGCTGCCATTGTGGATCCGGTGCAGCCCCAGAAGGTCGTGGACGCGGCG
AGAAAGCACGGGGTGAAACTGACCACAGTGCTCACCACCCACCACCACTGGGACCATGCT
GGCGGGAATGAGAAACTGGTCAAGCTGGAGTCGGGACTGAAGGTGTACGGGGGTGACGAC
CGTATCGGGGCCCTGACTCACAAGATCACTCACCTGTCCACACTGCAGGTGGGGTCTCTG
AACGTCAAGTGCCTGGCGACCCCGTGCCACACTTCAGGACACATTTGTTACTTCGTGAGC
AAGCCCGGAGGCTCGGAGCCCCCTGCCGTGTTCACAGGTGACACCTTGTTTGTGGCTGGC
TGCGGGAAGTTCTATGAAGGGACTGCGGATGAGATGTGTAAAGCTCTGCTGGAGGTCTTG
GGCCGGCTCCCCCCGGACACAAGAGTCTACTGTGGCCACGAGTACACCATCAACAACCTC
AAGTTTGCACGCCACGTGGAGCCCGGCAATGCCGCCATCCGGGAGAAGCTGGCCTGGGCC
AAGGAGAAGTACAGCATCGGGGAGCCCACAGTGCCATCCACCCTGGCAGAGGAGTTTACC
TACAACCCCTTCATGAGAGTGAGGGAGAAGACGGTGCAGCAGCACGCAGGTGAGACGGAC
CCGGTGACCACCATGCGGGCCGTGCGCAGGGAGAAGGACCAGTTCAAGATGCCCCGGGAC
TGA
GenBank Gene IDX90999
GeneCard IDNot Available
GenAtlas IDHAGH
HGNC IDHGNC:4805
Chromosome Location16
Locus16p13.3
References
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