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NameRibonuclease H2 subunit B
Synonyms
  • AGS2
  • Aicardi-Goutieres syndrome 2 protein
  • Deleted in lymphocytic leukemia 8
  • DLEU8
  • Ribonuclease HI subunit B
  • RNase H2 subunit B
Gene NameRNASEH2B
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009183|Ribonuclease H2 subunit B
MAAGVDCGDGVGARQHVFLVSEYLKDASKKMKNGLMFVKLVNPCSGEGAIYLFNMCLQQL
FEVKVFKEKHHSWFINQSVQSGGLLHFATPVDPLFLLLHYLIKADKEGKFQPLDQVVVDN
VFPNCILLLKLPGLEKLLHHVTEEKGNPEIDNKKYYKYSKEKTLKWLEKKVNQTVAALKT
NNVNVSSRVQSTAFFSGDQASTDKEEDYIRYAHGLISDYIPKELSDDLSKYLKLPEPSAS
LPNPPSKKIKLSDEPVEAKEDYTKFNTKDLKTEKKNSKMTAAQKALAKVDKSGMKSIDTF
FGVKNKKKIGKV
Number of residues312
Molecular Weight35138.455
Theoretical pINot Available
GO Classification
Functions
  • RNA-DNA hybrid ribonuclease activity
Processes
  • regulation of DNA damage checkpoint
  • ribonucleotide metabolic process
  • in utero embryonic development
  • negative regulation of gene expression
  • RNA catabolic process
  • positive regulation of fibroblast proliferation
  • regulation of G2/M transition of mitotic cell cycle
Components
  • ribonuclease H2 complex
  • nucleus
General FunctionRna-dna hybrid ribonuclease activity
Specific FunctionNon catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ5TBB1
UniProtKB Entry NameRNH2B_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0013658|Ribonuclease H2 subunit B (RNASEH2B)
ATGGCCGCTGGCGTGGACTGCGGGGACGGGGTTGGCGCCCGGCAGCACGTGTTCCTGGTT
TCAGAATATTTAAAAGATGCTTCAAAGAAGATGAAAAATGGGCTAATGTTTGTAAAACTG
GTTAACCCCTGTTCAGGAGAAGGAGCCATTTACTTGTTCAATATGTGTCTACAGCAGCTG
TTTGAAGTAAAAGTTTTCAAGGAAAAACACCATTCTTGGTTTATAAATCAATCAGTTCAA
TCAGGAGGTCTTCTCCATTTTGCCACACCTGTGGATCCTCTATTTCTGCTTCTCCACTAC
CTCATAAAGGCTGATAAGGAGGGGAAGTTTCAGCCCCTTGATCAAGTTGTGGTGGATAAC
GTGTTTCCAAATTGCATCTTGTTGCTGAAACTTCCTGGACTTGAGAAGTTACTTCATCAT
GTGACAGAGGAAAAAGGTAATCCAGAAATAGACAACAAGAAATATTACAAGTACAGCAAA
GAGAAGACATTAAAGTGGCTGGAAAAAAAGGTTAATCAAACTGTGGCAGCATTAAAAACC
AATAATGTGAATGTCAGTTCCCGGGTACAGTCAACTGCATTTTTCTCTGGTGACCAAGCT
TCCACTGACAAGGAAGAGGATTATATTCGTTATGCCCATGGTCTGATATCTGACTACATC
CCTAAAGAATTAAGTGATGACTTATCTAAATACTTAAAGCTTCCAGAACCTTCAGCCTCA
TTGCCAAATCCTCCATCAAAGATGGCAGCACAAAGACAGAAAAGGGGCAAGTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:25671
Chromosome Location13
LocusNot Available
References
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