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NameKeratin-associated protein 5-3
Synonyms
  • KAP5-9
  • KAP5.3
  • Keratin-associated protein 5-9
  • Keratin-associated protein 5.3
  • Keratin-associated protein 5.9
  • KRTAP5-9
  • KRTAP5.3
  • KRTAP5.9
  • UHS KerB-like
  • Ultrahigh sulfur keratin-associated protein 5.3
Gene NameKRTAP5-3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013128|Keratin-associated protein 5-3
MGCSGCSGGCGSSCGGCGSSCGGCGSGYGGCGSGCCVPVCCCKPVCCCVPACSCSSCGSC
GGSKGVCGSCGGCKGGCGSCGGSKGGCGSSCCVPVCCSSSCGSCGGSKGVCGFRGGSKGG
CGSCGCSQCSCYKPCCCSSGCGSSCCQSSCCKPSCSQSSCCKPCCSQSSCCKPCCCSSGC
GSSCCQSSCCKPCCSQSSCCKPCCCSSGCGSSCCQSSCCKPCSSQSSCCVPICCQCKI
Number of residues238
Molecular Weight22105.295
Theoretical pINot Available
GO Classification
Components
  • keratin filament
General FunctionNot Available
Specific FunctionIn the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Pfam Domain FunctionNot Available
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ6L8H2
UniProtKB Entry NameKRA53_HUMAN
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0013129|Keratin-associated protein 5-3 (KRTAP5-3)
ATGGGCTGCTCTGGCTGCTCTGGAGGCTGTGGCTCCAGCTGTGGGGGCTGTGGCTCCAGC
TGTGGGGGCTGTGGCTCCGGCTATGGGGGCTGTGGCTCCGGCTGCTGTGTACCTGTCTGC
TGCTGCAAGCCCGTGTGCTGCTGTGTGCCAGCCTGTTCCTGCTCCAGCTGTGGCTCCTGT
GGGGGCTCCAAGGGGGTCTGTGGCTCTTGTGGGGGCTGCAAGGGGGGCTGTGGCTCCTGT
GGAGGCTCCAAGGGGGGCTGTGGCTCCAGCTGCTGTGTGCCCGTCTGCTGCTCCTCCAGC
TGTGGCTCCTGTGGGGGTTCCAAGGGGGTCTGTGGATTTCGTGGGGGCTCCAAGGGGGGC
TGCGGTTCTTGTGGCTGCTCCCAGTGCAGCTGCTATAAGCCCTGCTGCTGCTCCTCAGGC
TGTGGGTCATCCTGCTGCCAGTCCAGCTGCTGCAAGCCCAGCTGCTCCCAGTCCAGCTGC
TGTAAGCCCTGCTGTTCCCAGTCCAGCTGCTGTAAGCCCTGCTGCTGCTCCTCAGGCTGT
GGGTCATCCTGCTGCCAGTCCAGCTGCTGCAAACCCTGCTGTTCCCAGTCCAGCTGCTGT
AAGCCCTGCTGCTGCTCCTCAGGCTGTGGGTCATCCTGCTGCCAGTCCAGCTGCTGCAAG
CCCTGCTCCTCCCAGTCCAGCTGCTGTGTCCCAATTTGCTGCCAGTGCAAGATCTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:23598
Chromosome Location11
LocusNot Available
References
  1. Yahagi S, Shibuya K, Obayashi I, Masaki H, Kurata Y, Kudoh J, Shimizu N: Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11. Biochem Biophys Res Commun. 2004 Jun 4;318(3):655-64. 15144888