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NameLactase-like protein
Synonyms
  • Klotho/lactase-phlorizin hydrolase-related protein
  • KLPH
Gene NameLCTL
OrganismHuman
Amino acid sequence
>lcl|BSEQ0007839|Lactase-like protein
MKPVWVATLLWMLLLVPRLGAARKGSPEEASFYYGTFPLGFSWGVGSSAYQTEGAWDQDG
KGPSIWDVFTHSGKGKVLGNETADVACDGYYKVQEDIILLRELHVNHYRFSLSWPRLLPT
GIRAEQVNKKGIEFYSDLIDALLSSNITPIVTLHHWDLPQLLQVKYGGWQNVSMANYFRD
YANLCFEAFGDRVKHWITFSDPRAMAEKGYETGHHAPGLKLRGTGLYKAAHHIIKAHAKA
WHSYNTTWRSKQQGLVGISLNCDWGEPVDISNPKDLEAAERYLQFCLGWFANPIYAGDYP
QVMKDYIGRKSAEQGLEMSRLPVFSLQEKSYIKGTSDFLGLGHFTTRYITERNYPSRQGP
SYQNDRDLIELVDPNWPDLGSKWLYSVPWGFRRLLNFAQTQYGDPPIYVMENGASQKFHC
TQLCDEWRIQYLKGYINEMLKAIKDGANIKGYTSWSLLDKFEWEKGYSDRYGFYYVEFND
RNKPRYPKASVQYYKKIIIANGFPNPREVESWYLKALETCSINNQMLAAEPLLSHMQMVT
EIVVPTVCSLCVLITAVLLMLLLRRQS
Number of residues567
Molecular Weight65087.84
Theoretical pI8.12
GO Classification
Functions
  • hydrolase activity, hydrolyzing O-glycosyl compounds
Processes
  • carbohydrate metabolic process
Components
  • brush border
  • endoplasmic reticulum membrane
  • integral component of membrane
General FunctionHydrolase activity, hydrolyzing o-glycosyl compounds
Specific FunctionNot Available
Pfam Domain Function
Transmembrane Regions542-562
GenBank Protein ID37182579
UniProtKB IDQ6UWM7
UniProtKB Entry NameLCTL_HUMAN
Cellular LocationEndoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0019521|Lactase-like protein (LCTL)
ATGGCCAACTACTTCAGAGACTACGCCAACCTGTGCTTTGAGGCCTTTGGGGACCGTGTG
AAGCACTGGATCACGTTCAGTGATCCTCGGGCAATGGCAGAAAAAGGCTATGAGACGGGC
CACCATGCGCCGGGCCTGAAGCTCCGCGGCACCGGCCTGTACAAGGCAGCACACCACATC
ATTAAGGCCCACGCCAAAGCCTGGCATTCTTATAACACCACGTGGCGCAGCAAGCAGCAA
GGTCTGGTGGGAATTTCATTGAACTGTGACTGGGGGGAACCTGTGGACATTAGTAACCCC
AAGGACCTAGAGGCTGCCGAGAGATACCTACAGTTCTGTCTGGGCTGGTTTGCCAACCCC
ATTTATGCCGGTGACTACCCCCAAGTCATGAAGGACTACATTGGAAGAAAGAGTGCAGAG
CAAGGCCTGGAGATGTCGAGGTTACCGGTGTTCTCACTCCAGGAGAAGAGCTACATTAAA
GGCACATCCGATTTCTTGGGATTAGGTCATTTTACTACTCGGTACATCACGGAAAGGAAC
TACCCCTCCCGCCAGGGGCCCAGCTACCAGAACGATCGTGACTTGATAGAGCTGGTTGAC
CCAAACTGGCCAGATCTGGGGTCTAAATGGCTATATTCTGTGCCATGGGGATTTAGGAGG
CTCCTTAACTTTGCTCAGACTCAATACGGTGATCCTCCCATATATGTGATGGAAAATGGA
GCATCTCAAAAATTCCACTGTACTCAATTATGTGATGAGTGGAGAATTCAATACCTTAAA
GGATACATAAATGAAATGCTAAAAGCTATAAAAGATGGTGCTAATATAAAGGGGTATACT
TCCTGGTCTCTGTTGGATAAGTTTGAATGGGAGAAAGGATACTCAGATAGATATGGATTC
TACTATGTTGAATTTAACGACAGAAATAAGCCTCGCTATCCAAAGGCTTCAGTTCAATAT
TACAAGAAGATTATCATTGCCAATGGGTTTCCCAATCCAAGAGAGGTGGAAAGTTGGTAC
CTCAAAGCTTTGGAAACTTGCTCTATCAACAATCAGATGCTTGCTGCAGAGCCCTTGCTA
AGTCACATGCAAATGGTTACGGAGATCGTGGTACCCACTGTCTGCTCCCTCTGTGTCCTC
ATCACTGCTGTTCTACTAATGCTCCTCCTGAGGAGGCAGAGCTGA
GenBank Gene IDAY358729
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:15583
Chromosome Location15
Locus15q22.31
References
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  3. Zody MC, Garber M, Sharpe T, Young SK, Rowen L, O'Neill K, Whittaker CA, Kamal M, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Kodira CD, Madan A, Qin S, Yang X, Abbasi N, Abouelleil A, Arachchi HM, Baradarani L, Birditt B, Bloom S, Bloom T, Borowsky ML, Burke J, Butler J, Cook A, DeArellano K, DeCaprio D, Dorris L 3rd, Dors M, Eichler EE, Engels R, Fahey J, Fleetwood P, Friedman C, Gearin G, Hall JL, Hensley G, Johnson E, Jones C, Kamat A, Kaur A, Locke DP, Madan A, Munson G, Jaffe DB, Lui A, Macdonald P, Mauceli E, Naylor JW, Nesbitt R, Nicol R, O'Leary SB, Ratcliffe A, Rounsley S, She X, Sneddon KM, Stewart S, Sougnez C, Stone SM, Topham K, Vincent D, Wang S, Zimmer AR, Birren BW, Hood L, Lander ES, Nusbaum C: Analysis of the DNA sequence and duplication history of human chromosome 15. Nature. 2006 Mar 30;440(7084):671-5. 16572171
  4. Zhang Z, Henzel WJ: Signal peptide prediction based on analysis of experimentally verified cleavage sites. Protein Sci. 2004 Oct;13(10):2819-24. Epub 2004 Aug 31. 15340161