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Synaptic vesicle glycoprotein 2A

NameSynaptic vesicle glycoprotein 2A
Synonyms
  • KIAA0736
Gene NameSV2A
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001977|Synaptic vesicle glycoprotein 2A
MEEGFRDRAAFIRGAKDIAKEVKKHAAKKVVKGLDRVQDEYSRRSYSRFEEEDDDDDFPA
PSDGYYRGEGTQDEEEGGASSDATEGHDEDDEIYEGEYQGIPRAESGGKGERMADGAPLA
GVRGGLSDGEGPPGGRGEAQRRKEREELAQQYEAILRECGHGRFQWTLYFVLGLALMADG
VEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLS
VNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFW
MIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRF
FLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTIHQEDELIEIQSDTGTWYQRW
GVRALSLGGQVWGNFLSCFGPEYRRITLMMMGVWFTMSFSYYGLTVWFPDMIRHLQAVDY
ASRTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECYFEDVT
SSNTFFRNCTFINTVFYNTDLFEYKFVNSRLINSTFLHNKEGCPLDVTGTGEGAYMVYFV
SFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGG
VSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFAS
AALALGSSLALKLPETRGQVLQ
Number of residues742
Molecular Weight82694.665
Theoretical pI5.26
GO Classification
Functions
  • receptor activity
  • protein kinase binding
  • transmembrane transporter activity
Processes
  • neurotransmitter transport
  • cellular calcium ion homeostasis
Components
  • endoplasmic reticulum
  • plasma membrane
  • synaptic vesicle
  • integral component of membrane
  • cell-cell junction
  • presynaptic active zone
  • terminal bouton
  • synaptic vesicle membrane
  • neuromuscular junction
  • cytoplasm
General FunctionTransmembrane transporter activity
Specific FunctionPlays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity).
Pfam Domain Function
Transmembrane Regions170-190 206-226 234-254 263-283 295-315 335-355 448-468 599-619 627-647 652-672 686-708 713-731
GenBank Protein ID40788343
UniProtKB IDQ7L0J3
UniProtKB Entry NameSV2A_HUMAN
Cellular LocationCell junction
Gene sequence
>lcl|BSEQ0010696|Synaptic vesicle glycoprotein 2A (SV2A)
ATGACTGCCTGCTTATCTTGGCCTTTGCCCACAGACCTGTTCGAGTACAAGTTTGTGAAC
AGCCGTCTGATAAACAGTACATTCCTGCACAACAAGGAGGGCTGCCCGCTAGACGTGACA
GGGACGGGCGAAGGTGCCTACATGGTATACTTTGTGAGCTTCCTGGGGACACTGGCAGTG
CTTCCTGGGAATATCGTGTCTGCCCTGCTCATGGACAAGATCGGCAGGCTCAGAATGCTT
GCTGGCTCCAGCGTGATGTCCTGTGTCTCCTGCTTCTTCCTGTCTTTTGGGAACAGTGAG
TCGGCCATGATCGCTCTGCTCTGCCTTTTTGGCGGGGTCAGCATTGCATCCTGGAATGCG
CTGGACGTGTTGACTGTTGAACTCTACCCCTCAGACAAGAGGACCACAGCTTTTGGCTTC
CTGAATGCCCTGTGTAAGCTGGCAGCTGTGCTGGGGATCAGCATCTTCACATCCTTCGTG
GGAATCACCAAGGCTGCACCCATCCTCTTTGCCTCAGCTGCCCTTGCCCTTGGCAGCTCT
CTGGCCCTGAAGCTGCCTGAGACCCGGGGGCAGGTGCTGCAGTGA
GenBank Gene IDAB018279
GeneCard IDNot Available
GenAtlas IDSV2A
HGNC IDHGNC:20566
Chromosome Location1
Locus1q21.2
References
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