L-xylulose reductase

NameL-xylulose reductase
Synonyms
  • 1.1.1.10
  • Carbonyl reductase II
  • Dicarbonyl/L-xylulose reductase
  • kiDCR
  • Kidney dicarbonyl reductase
  • SDR20C1
  • Short chain dehydrogenase/reductase family 20C member 1
  • Sperm surface protein P34H
  • XR
Gene NameDCXR
OrganismHuman
Amino acid sequence
>lcl|BSEQ0010613|L-xylulose reductase
MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVD
LGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR
GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPT
VVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG
FWAC
Number of residues244
Molecular Weight25912.875
Theoretical pI8.23
GO Classification
Functions
  • L-xylulose reductase (NADP+) activity
  • oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
Processes
  • D-xylose metabolic process
  • NADP metabolic process
  • xylulose metabolic process
  • small molecule metabolic process
  • carbohydrate metabolic process
  • glucose metabolic process
  • oxidation-reduction process
  • protein homotetramerization
  • glucuronate catabolic process to xylulose 5-phosphate
Components
  • microvillus
  • brush border
  • cytoplasmic microtubule
  • nucleus
  • plasma membrane
  • extracellular exosome
General FunctionOxidoreductase activity, acting on nad(p)h, quinone or similar compound as acceptor
Specific FunctionCatalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID15425623
UniProtKB IDQ7Z4W1
UniProtKB Entry NameDCXR_HUMAN
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0010614|L-xylulose reductase (DCXR)
ATGGAGCTGTTCCTCGCGGGCCGCCGGGTGCTGGTCACCGGGGCAGGCAAAGGGCGCGGC
ACGGTCCAGGCGCTGCACGCGACGGGCGCGCGGGTGGTGGCTGTGAGCCGGACTCAGGCG
GATCTTGACAGCCTTGTCCGCGAGTGCCCGGGGATAGAACCCGTGTGCGTGGACCTGGGT
GACTGGGAGGCCACCGAGCGGGCGCTGGGCAGCGTGGGCCCCGTGGACCTGCTGGTGAAC
AACGCCGCTGTCGCCCTGCTGCAGCCCTTCCTGGAGGTCACCAAGGAGGCCTTTGACAGA
TCCTTTGAGGTGAACCTGCGTGCGGTCATCCAGGTGTCGCAGATTGTGGCCAGGGGCTTA
ATAGCCCGGGGAGTCCCAGGGGCCATCGTGAATGTCTCCAGCCAGTGCTCCCAGCGGGCA
GTAACTAACCATAGCGTCTACTGCTCCACCAAGGGTGCCCTGGACATGCTGACCAAGGTG
ATGGCCCTAGAGCTCGGGCCCCACAAGATCCGAGTGAATGCAGTAAACCCCACAGTGGTG
ATGACGTCCATGGGCCAGGCCACCTGGAGTGACCCCCACAAGGCCAAGACTATGCTGAAC
CGAATCCCACTTGGCAAGTTTGCTGAGGTAGAGCACGTGGTGAACGCCATCCTCTTTCTG
CTGAGTGACCGAAGTGGCATGACCACGGGTTCCACTTTGCCGGTGGAAGGGGGCTTCTGG
GCCTGCTGA
GenBank Gene IDAB013846
GeneCard IDNot Available
GenAtlas IDDCXR
HGNC IDHGNC:18985
Chromosome Location17
Locus17q25.3
References
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