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Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1
Name | Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 |
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Synonyms |
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Gene Name | PTPMT1 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0009020|Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 MAATALLEAGLARVLFYPTLLYTLFRGKVPGRAHRDWYHRIDPTVLLGALPLRSLTRQLV QDENVRGVITMNEEYETRFLCNSSQEWKRLGVEQLRLSTVDMTGIPTLDNLQKGVQFALK YQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLK EFHKQITARATKDGTFVISKT |
Number of residues | 201 |
Molecular Weight | 22843.38 |
Theoretical pI | Not Available |
GO Classification | Functions
Processes
Components
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General Function | Protein tyrosine/serine/threonine phosphatase activity |
Specific Function | Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity). |
Pfam Domain Function |
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Transmembrane Regions | Not Available |
GenBank Protein ID | Not Available |
UniProtKB ID | Q8WUK0 |
UniProtKB Entry Name | PTPM1_HUMAN |
Cellular Location | Mitochondrion inner membrane |
Gene sequence | >lcl|BSEQ0017669|Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (PTPMT1) ATGGCGGCCACCGCGCTGCTGGAGGCCGGCCTGGCGCGGGTGCTCTTCTACCCGACGCTG CTCTACACCCTGTTCCGCGGGAAGGTGCCGGGTCGGGCGCACCGGGACTGGTACCACCGC ATCGACCCCACCGTGCTGCTGGGCGCGCTGCCGTTGCGGAGCTTGACGCGCCAGGTGAGC CGGGCCGGGGAGCCCGGGCCCCTGCCCCGTCCCCGCCGCTCCGTCCCTGTCGGGCCGCTG GGGTCTCCACCGTCTTTGCTGAGCCACCTCTTTGCCTCGGCAGCTGGTACAGGACGAGAA CGTGCGCGGGGTGATCACCATGAACGAGGAGTACGAGACGAGGTTCCTGTGCAACTCTTC ACAGGTGCACAAATGGAGTCCAGAGGAGGCTGTAAGAGCCATCGCCAAGATCCGGTCATA CATCCACATCAGGCCTGGCCAGCTGGATGTTCTTAA |
GenBank Gene ID | Not Available |
GeneCard ID | Not Available |
GenAtlas ID | Not Available |
HGNC ID | HGNC:26965 |
Chromosome Location | 11 |
Locus | Not Available |
References |
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