Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

NamePhosphatidylglycerophosphatase and protein-tyrosine phosphatase 1
Synonyms
  • 3.1.3.27
  • MOSP
  • Phosphoinositide lipid phosphatase
  • PLIP
  • Protein-tyrosine phosphatase mitochondrial 1
  • PTEN-like phosphatase
Gene NamePTPMT1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009020|Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1
MAATALLEAGLARVLFYPTLLYTLFRGKVPGRAHRDWYHRIDPTVLLGALPLRSLTRQLV
QDENVRGVITMNEEYETRFLCNSSQEWKRLGVEQLRLSTVDMTGIPTLDNLQKGVQFALK
YQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLK
EFHKQITARATKDGTFVISKT
Number of residues201
Molecular Weight22843.38
Theoretical pINot Available
GO Classification
Functions
  • phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
  • phosphatidylglycerophosphatase activity
  • protein tyrosine phosphatase activity
  • protein tyrosine/serine/threonine phosphatase activity
Processes
  • phosphatidylglycerol biosynthetic process
  • small molecule metabolic process
  • glycerophospholipid biosynthetic process
  • phospholipid metabolic process
  • protein dephosphorylation
  • inositol phosphate dephosphorylation
  • cardiolipin biosynthetic process
Components
  • integral component of mitochondrial inner membrane
  • mitochondrion
  • nucleus
General FunctionProtein tyrosine/serine/threonine phosphatase activity
Specific FunctionLipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ8WUK0
UniProtKB Entry NamePTPM1_HUMAN
Cellular LocationMitochondrion inner membrane
Gene sequence
>lcl|BSEQ0017669|Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (PTPMT1)
ATGGCGGCCACCGCGCTGCTGGAGGCCGGCCTGGCGCGGGTGCTCTTCTACCCGACGCTG
CTCTACACCCTGTTCCGCGGGAAGGTGCCGGGTCGGGCGCACCGGGACTGGTACCACCGC
ATCGACCCCACCGTGCTGCTGGGCGCGCTGCCGTTGCGGAGCTTGACGCGCCAGGTGAGC
CGGGCCGGGGAGCCCGGGCCCCTGCCCCGTCCCCGCCGCTCCGTCCCTGTCGGGCCGCTG
GGGTCTCCACCGTCTTTGCTGAGCCACCTCTTTGCCTCGGCAGCTGGTACAGGACGAGAA
CGTGCGCGGGGTGATCACCATGAACGAGGAGTACGAGACGAGGTTCCTGTGCAACTCTTC
ACAGGTGCACAAATGGAGTCCAGAGGAGGCTGTAAGAGCCATCGCCAAGATCCGGTCATA
CATCCACATCAGGCCTGGCCAGCTGGATGTTCTTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:26965
Chromosome Location11
LocusNot Available
References
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