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NameRiboflavin kinase
Synonyms
  • 2.7.1.26
  • ATP:riboflavin 5'-phosphotransferase
  • Flavokinase
Gene NameRFK
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037001|Riboflavin kinase
MRHLPYFCRGQVVRGFGRGSKQLGIPTANFPEQVVDNLPADISTGIYYGWASVGSGDVHK
MVVSIGWNPYYKNTKKSMETHIMHTFKEDFYGEILNVAIVGYLRPEKNFDSLESLISAIQ
GDIEEAKKRLELPEHLKIKEDNFFQVSKSKIMNGH
Number of residues155
Molecular Weight17623.08
Theoretical pI8.22
GO Classification
Functions
  • ATP binding
  • riboflavin kinase activity
  • metal ion binding
Processes
  • apoptotic process
  • positive regulation of NAD(P)H oxidase activity
  • vitamin metabolic process
  • water-soluble vitamin metabolic process
  • FMN biosynthetic process
  • riboflavin biosynthetic process
  • riboflavin metabolic process
  • reactive oxygen species metabolic process
  • small molecule metabolic process
Components
  • cytosol
  • cytoplasm
  • mitochondrion
General FunctionRiboflavin kinase activity
Specific FunctionCatalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID7023634
UniProtKB IDQ969G6
UniProtKB Entry NameRIFK_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0010118|Riboflavin kinase (RFK)
ATGAGGCACCTGCCTTACTTCTGCCGGGGTCAAGTGGTGCGGGGCTTCGGCCGCGGCTCC
AAGCAGCTGGGCATCCCCACAGCTAATTTTCCTGAGCAAGTGGTAGATAATCTTCCAGCT
GATATATCCACTGGTATTTACTATGGTTGGGCCAGTGTTGGAAGTGGAGATGTCCATAAG
ATGGTGGTGAGCATAGGATGGAACCCATATTACAAGAATACGAAGAAGTCTATGGAAACA
CATATCATGCATACCTTCAAAGAGGACTTCTATGGGGAAATCCTCAATGTGGCCATTGTT
GGCTACCTGAGACCAGAAAAGAACTTTGATTCTTTAGAGTCACTTATTTCAGCAATTCAA
GGTGATATTGAAGAAGCTAAGAAACGACTAGAGTTACCAGAACATTTGAAAATCAAAGAA
GACAATTTCTTCCAGGTTTCTAAAAGCAAAATAATGAATGGCCACTGA
GenBank Gene IDAK002011
GeneCard IDNot Available
GenAtlas IDRFK
HGNC IDHGNC:30324
Chromosome Location9
Locus9q21.13
References
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