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NameHistone H2A type 1-H
Synonyms
  • HIST1H2AI
  • Histone H2A/s
Gene NameHIST1H2AH
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013496|Histone H2A type 1-H
MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLT
AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKK
TESHHKAK
Number of residues128
Molecular Weight13906.145
Theoretical pINot Available
GO Classification
Functions
  • DNA binding
Processes
  • chromatin organization
  • chromatin silencing
Components
  • nucleosome
  • extracellular exosome
  • nuclear chromatin
General FunctionDna binding
Specific FunctionCore component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ96KK5
UniProtKB Entry NameH2A1H_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0013497|Histone H2A type 1-H (HIST1H2AH)
ATGTCTGGACGTGGCAAGCAAGGCGGTAAAGCTCGCGCCAAGGCCAAGACCCGCTCTTCT
CGGGCTGGGCTTCAGTTCCCCGTGGGCCGAGTGCACCGCCTGCTCCGCAAGGGTAATTAT
GCCGAGCGGGTTGGAGCCGGCGCGCCAGTGTACCTGGCTGCGGTGCTGGAGTACCTGACC
GCTGAGATCCTGGAGCTGGCTGGCAATGCGGCCCGCGACAACAAGAAGACCCGTATCATC
CCGCGTCACCTCCAACTGGCCATCCGCAACGACGAGGAGCTCAACAAGCTGCTGGGCAAA
GTCACCATCGCGCAGGGTGGTGTCTTGCCCAATATCCAGGCCGTGCTGCTGCCTAAGAAG
ACTGAGAGCCACCATAAGGCCAAATAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:13671
Chromosome Location6
LocusNot Available
References
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