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NameHistone H2B type 1-L
Synonyms
  • H2B/c
  • H2BFC
  • Histone H2B.c
Gene NameHIST1H2BL
OrganismHuman
Amino acid sequence
>lcl|BSEQ0017638|Histone H2B type 1-L
MPELAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAM
GIMNSFVNDIFERIASEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVT
KYTSSK
Number of residues126
Molecular Weight13952.095
Theoretical pINot Available
GO Classification
Functions
  • DNA binding
Processes
  • chromatin organization
  • nucleosome assembly
Components
  • cytoplasm
  • nucleus
  • extracellular exosome
  • nucleoplasm
  • nuclear nucleosome
  • nucleosome
General FunctionDna binding
Specific FunctionCore component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ99880
UniProtKB Entry NameH2B1L_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0017639|Histone H2B type 1-L (HIST1H2BL)
ATGCCCGAGCTGGCCAAGTCTGCTCCCGCCCCGAAGAAGGGCTCCAAGAAGGCGGTGACC
AAGGCCCAGAAGAAGGATGGCAAGAAGCGCAAGCGCAGCCGCAAGGAGAGCTACTCCGTG
TACGTGTACAAGGTGCTGAAGCAGGTCCACCCCGACACCGGCATCTCTTCTAAGGCCATG
GGAATCATGAACTCCTTCGTCAACGACATCTTCGAGCGCATCGCAAGCGAGGCTTCCCGC
CTGGCGCACTACAACAAGCGCTCGACCATCACCTCCAGGGAGATCCAGACCGCCGTGCGC
CTGCTGCTTCCGGGGGAGCTGGCCAAGCACGCGGTGTCGGAGGGCACCAAGGCCGTCACC
AAGTACACCAGCTCCAAGTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:4748
Chromosome Location6
LocusNot Available
References
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